{
  "schemaVersion": 1,
  "capturedAt": "2026-09-14T08:27:22.726Z",
  "sha256": "446d4a01cb86859521d5d61bc0d41a945898c33f9ca0a370ee936d6ab06dcbd0",
  "work": {
    "id": "TAP-CON-0004",
    "kind": "concept",
    "key": "allostatic-load",
    "locale": "zh",
    "path": "/zh/topics/allostatic-load/",
    "title": "适应负荷",
    "description": "Allostatic Load 描述反复或长期的适应过程可能伴随的累积生理成本。它连接了长期挑战与多个身体系统的变化。",
    "rights": "© The Allostasis Project。保留所有权利。除法律允许的例外外，转载或改编需另行授权。",
    "version": "0.1",
    "updatedAt": "2026-09-14",
    "editorial": {
      "contentType": "scientific-concept",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-09-14",
      "version": "0.1",
      "author": null,
      "reviewer": null,
      "revisions": []
    },
    "sections": [
      {
        "id": "introduction",
        "title": "概览",
        "paragraphs": [
          "反复适应，也可能留下成本。",
          "Allostatic Load 描述反复或长期的适应过程可能伴随的累积生理成本。它连接了长期挑战与多个身体系统的变化。",
          "它是研究概念，不能仅凭疲劳感或一项指标判断。"
        ]
      },
      {
        "id": "cost",
        "title": "反复适应可能带来的成本",
        "paragraphs": [
          "适应负荷框架将反复的要求与累积生理成本联系起来。压力介质既可能发挥保护作用，也可能带来损伤，需要结合其活动模式与情境理解。[1][2]"
        ]
      },
      {
        "id": "measurement",
        "title": "一个概念，多种测量",
        "paragraphs": [
          "一篇综述之综述记录了将适应负荷转化为测量指标时的差异。解释某项研究的指数，需要查看其指标组合、阈值和人群。[3]"
        ]
      },
      {
        "id": "boundaries",
        "title": "不能直接用于个人诊断",
        "paragraphs": [
          "本专题不会把疲劳感或单项检测结果换算成适应负荷。下方的深度文章进一步解释概念和测量边界。"
        ]
      }
    ],
    "references": [
      {
        "id": "mcewen-1993",
        "title": "Stress and the individual. Mechanisms leading to disease",
        "authors": "Bruce S. McEwen · Eliot Stellar",
        "journal": "Archives of Internal Medicine",
        "year": "1993",
        "url": "https://pubmed.ncbi.nlm.nih.gov/8379800/",
        "doi": "10.1001/archinte.1993.00410180039004",
        "pmid": "8379800"
      },
      {
        "id": "mcewen-1998",
        "title": "Protective and damaging effects of stress mediators",
        "authors": "Bruce S. McEwen",
        "journal": "New England Journal of Medicine",
        "year": "1998",
        "url": "https://pubmed.ncbi.nlm.nih.gov/9428819/",
        "doi": "10.1056/NEJM199801153380307",
        "pmid": "9428819"
      },
      {
        "id": "measurement-review",
        "title": "Allostatic Load Measurement: A Systematic Review of Reviews, Database Inventory, and Considerations for Neighborhood Research",
        "authors": "Shawna Beese · Julie Postma · Janessa M. Graves",
        "journal": "International Journal of Environmental Research and Public Health",
        "year": "2022",
        "url": "https://pubmed.ncbi.nlm.nih.gov/36554888/",
        "doi": "10.3390/ijerph192417006",
        "pmid": "36554888"
      }
    ],
    "type": "CON"
  }
}