{
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  "capturedAt": "2026-10-27T11:18:42.866Z",
  "sha256": "41d412f516a19bdb33f63a4bdfbf0501c70328d054d64aea32310bacb56d3ddc",
  "work": {
    "id": "TAP-RDN-0001",
    "type": "RDN",
    "kind": "note",
    "key": "mcewen-1993",
    "locale": "en",
    "path": "/research/mcewen-1993/",
    "title": "TAP reading note: Stress and the individual. Mechanisms leading to disease",
    "description": "Introduces allostatic load as a way to understand the physiological costs that may accompany prolonged challenges.",
    "rights": "© The Allostasis Project. All rights reserved. Reproduction or adaptation requires separate permission, subject to applicable legal exceptions.",
    "version": "0.2",
    "updatedAt": "2026-10-27",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-10-27",
      "version": "0.2",
      "author": null,
      "reviewer": null,
      "workflow": {
        "ai": {
          "usage": "used",
          "system": "TAP Research Agent / OpenAI Codex",
          "scope": "Bilingual editorial revision and consolidation of scope statements based on the published text.",
          "version": "0.2",
          "tasks": [
            "Bilingual editing",
            "Scope and citation-position comparison"
          ]
        }
      },
      "revisions": [
        {
          "date": "2026-10-27",
          "version": "0.2",
          "description": "Reframed scope in terms of study design, population, outcomes and observation window."
        }
      ]
    },
    "original": {
      "id": "mcewen-1993",
      "title": "Stress and the individual. Mechanisms leading to disease",
      "authors": "Bruce S. McEwen · Eliot Stellar",
      "journal": "Archives of Internal Medicine",
      "year": "1993",
      "url": "https://pubmed.ncbi.nlm.nih.gov/8379800/",
      "doi": "10.1001/archinte.1993.00410180039004",
      "pmid": "8379800"
    },
    "references": [
      {
        "id": "mcewen-1993",
        "title": "Stress and the individual. Mechanisms leading to disease",
        "authors": "Bruce S. McEwen · Eliot Stellar",
        "journal": "Archives of Internal Medicine",
        "year": "1993",
        "url": "https://pubmed.ncbi.nlm.nih.gov/8379800/",
        "doi": "10.1001/archinte.1993.00410180039004",
        "pmid": "8379800"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "What the study found",
        "paragraphs": [
          "Introduces allostatic load as a way to understand the physiological costs that may accompany prolonged challenges."
        ]
      },
      {
        "id": "limits",
        "title": "Scope & limitations",
        "paragraphs": [
          "Synthesis of human and animal research; no single trial sample",
          "This conceptual review connects human and animal research to explain cumulative costs of adaptation. Specific intervention effects require corresponding human studies."
        ]
      },
      {
        "id": "sample",
        "title": "Population & sample",
        "paragraphs": [
          "Synthesis of human and animal research; no single trial sample"
        ]
      },
      {
        "id": "exposure",
        "title": "Exposure or intervention",
        "paragraphs": [
          "Repeated/chronic environmental demands; conceptual synthesis"
        ]
      },
      {
        "id": "outcomes",
        "title": "Outcomes",
        "paragraphs": [
          "Physiological adaptation and disease mechanisms"
        ]
      },
      {
        "id": "duration",
        "title": "Time frame",
        "paragraphs": [
          "No single observation period"
        ]
      },
      {
        "id": "funding",
        "title": "Research funding",
        "paragraphs": [
          "Not yet verified against the full text."
        ]
      },
      {
        "id": "conflicts",
        "title": "Research conflicts of interest",
        "paragraphs": [
          "Not yet verified against the full text."
        ]
      },
      {
        "id": "basis",
        "title": "Reading scope",
        "paragraphs": [
          "This selected reading note links to the original source. Bibliographic details have been checked; full-text verification is incomplete."
        ]
      }
    ]
  }
}