{
  "schemaVersion": 1,
  "capturedAt": "2026-10-27T11:18:42.890Z",
  "sha256": "032455d3c6a18a7472abbb19540e3ea25ec6590eb8102ca181cbf81b4ed5ed8b",
  "work": {
    "id": "TAP-RDN-0001",
    "type": "RDN",
    "kind": "note",
    "key": "mcewen-1993",
    "locale": "zh",
    "path": "/zh/research/mcewen-1993/",
    "title": "TAP 导读: Stress and the individual. Mechanisms leading to disease",
    "description": "提出用适应负荷理解长期挑战可能伴随的生理成本。",
    "rights": "© The Allostasis Project。保留所有权利。除法律允许的例外外，转载或改编需另行授权。",
    "version": "0.2",
    "updatedAt": "2026-10-27",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-10-27",
      "version": "0.2",
      "author": null,
      "reviewer": null,
      "workflow": {
        "ai": {
          "usage": "used",
          "system": "TAP Research Agent / OpenAI Codex",
          "scope": "基于已发布正文的中英文表达修订与范围说明整理。",
          "version": "0.2",
          "tasks": [
            "中英文编辑",
            "范围说明与引用位置对照"
          ]
        }
      },
      "revisions": [
        {
          "date": "2026-10-27",
          "version": "0.2",
          "description": "按研究设计、人群、结局与观察窗口重写适用范围说明。"
        }
      ]
    },
    "original": {
      "id": "mcewen-1993",
      "title": "Stress and the individual. Mechanisms leading to disease",
      "authors": "Bruce S. McEwen · Eliot Stellar",
      "journal": "Archives of Internal Medicine",
      "year": "1993",
      "url": "https://pubmed.ncbi.nlm.nih.gov/8379800/",
      "doi": "10.1001/archinte.1993.00410180039004",
      "pmid": "8379800"
    },
    "references": [
      {
        "id": "mcewen-1993",
        "title": "Stress and the individual. Mechanisms leading to disease",
        "authors": "Bruce S. McEwen · Eliot Stellar",
        "journal": "Archives of Internal Medicine",
        "year": "1993",
        "url": "https://pubmed.ncbi.nlm.nih.gov/8379800/",
        "doi": "10.1001/archinte.1993.00410180039004",
        "pmid": "8379800"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "研究发现",
        "paragraphs": [
          "提出用适应负荷理解长期挑战可能伴随的生理成本。"
        ]
      },
      {
        "id": "limits",
        "title": "范围与局限",
        "paragraphs": [
          "综合人与动物研究；无单一试验样本",
          "这篇概念综述连接人与动物研究，用于解释适应过程的累积成本。具体干预效果需要相应的人体研究评价。"
        ]
      },
      {
        "id": "sample",
        "title": "研究人群与样本",
        "paragraphs": [
          "综合人与动物研究；无单一试验样本"
        ]
      },
      {
        "id": "exposure",
        "title": "暴露或干预",
        "paragraphs": [
          "反复或长期环境要求；概念整合"
        ]
      },
      {
        "id": "outcomes",
        "title": "观察结局",
        "paragraphs": [
          "生理适应与疾病机制"
        ]
      },
      {
        "id": "duration",
        "title": "时间范围",
        "paragraphs": [
          "没有统一观察时间"
        ]
      },
      {
        "id": "funding",
        "title": "研究资金来源",
        "paragraphs": [
          "尚未根据全文核实。"
        ]
      },
      {
        "id": "conflicts",
        "title": "研究利益关系",
        "paragraphs": [
          "尚未根据全文核实。"
        ]
      },
      {
        "id": "basis",
        "title": "导读范围",
        "paragraphs": [
          "本导读连接原始来源，供专题阅读参考。引文信息已经核对；尚未完成全文核查。"
        ]
      }
    ]
  }
}