{
  "schemaVersion": 1,
  "capturedAt": "2026-09-14T08:27:22.724Z",
  "sha256": "95ae475e7ddac6077353622195b5caddae1ba3bccf735f9731f9df688cd0c89c",
  "work": {
    "id": "TAP-RDN-0002",
    "kind": "note",
    "key": "mcewen-1998",
    "locale": "en",
    "path": "/research/mcewen-1998/",
    "title": "TAP reading note: Protective and damaging effects of stress mediators",
    "description": "Explores the dual nature of adaptation through the protective and damaging effects of stress mediators.",
    "rights": "© The Allostasis Project. All rights reserved. Reproduction or adaptation requires separate permission, subject to applicable legal exceptions.",
    "version": "0.1",
    "updatedAt": "2026-09-14",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-09-14",
      "version": "0.1",
      "author": null,
      "reviewer": null,
      "revisions": []
    },
    "original": {
      "id": "mcewen-1998",
      "title": "Protective and damaging effects of stress mediators",
      "authors": "Bruce S. McEwen",
      "journal": "New England Journal of Medicine",
      "year": "1998",
      "url": "https://pubmed.ncbi.nlm.nih.gov/9428819/",
      "doi": "10.1056/NEJM199801153380307",
      "pmid": "9428819"
    },
    "references": [
      {
        "id": "mcewen-1998",
        "title": "Protective and damaging effects of stress mediators",
        "authors": "Bruce S. McEwen",
        "journal": "New England Journal of Medicine",
        "year": "1998",
        "url": "https://pubmed.ncbi.nlm.nih.gov/9428819/",
        "doi": "10.1056/NEJM199801153380307",
        "pmid": "9428819"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "What the study found",
        "paragraphs": [
          "Explores the dual nature of adaptation through the protective and damaging effects of stress mediators."
        ]
      },
      {
        "id": "limits",
        "title": "Scope & limitations",
        "paragraphs": [
          "Review; no single trial sample",
          "This is a review of mechanisms and research context, not an individual diagnostic standard or a product clinical trial."
        ]
      },
      {
        "id": "sample",
        "title": "Population & sample",
        "paragraphs": [
          "Review; no single trial sample"
        ]
      },
      {
        "id": "exposure",
        "title": "Exposure or intervention",
        "paragraphs": [
          "Stress mediators; review"
        ]
      },
      {
        "id": "outcomes",
        "title": "Outcomes",
        "paragraphs": [
          "Protective and damaging actions of stress mediators"
        ]
      },
      {
        "id": "duration",
        "title": "Time frame",
        "paragraphs": [
          "No single observation period"
        ]
      },
      {
        "id": "funding",
        "title": "Research funding",
        "paragraphs": [
          "Not yet verified against the full text."
        ]
      },
      {
        "id": "conflicts",
        "title": "Research conflicts of interest",
        "paragraphs": [
          "Not yet verified against the full text."
        ]
      },
      {
        "id": "basis",
        "title": "Reading scope",
        "paragraphs": [
          "This selected reading note links to the original source. Bibliographic details have been checked; full-text verification is incomplete."
        ]
      }
    ],
    "type": "RDN"
  }
}