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  "work": {
    "id": "TAP-RDN-0003",
    "type": "RDN",
    "kind": "note",
    "key": "van-dongen-2003",
    "locale": "en",
    "path": "/research/van-dongen-2003/",
    "title": "TAP reading note: The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation",
    "description": "This study examines neurobehavioural and sleep-physiology changes during repeated sleep restriction and total sleep deprivation. This record currently provides the original-source and erratum entry points. Detailed estimates, model equations and quantitative interpretation are deferred until the formal 2004 erratum is checked.",
    "rights": "© The Allostasis Project. All rights reserved. Reproduction or adaptation requires separate permission, subject to applicable legal exceptions.",
    "version": "0.3",
    "updatedAt": "2026-10-29",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-10-29",
      "version": "0.3",
      "author": null,
      "reviewer": null,
      "workflow": {
        "ai": {
          "usage": "used",
          "system": "OpenAI Codex",
          "scope": "Assisted source comparison, evidence extraction and bilingual research-note preparation. The materials consulted and unresolved scientific issues are specified in each note.",
          "version": "0.3",
          "tasks": [
            "Source comparison and evidence extraction",
            "Bilingual research-note drafting and editorial comparison"
          ]
        }
      },
      "revisions": [
        {
          "date": "2026-10-27",
          "version": "0.2",
          "description": "Reframed scope in terms of study design, population, outcomes and observation window."
        },
        {
          "date": "2026-10-29",
          "version": "0.3",
          "description": "Recorded the formal 2004 erratum and deferred detailed estimates and model interpretation pending its text."
        }
      ]
    },
    "original": {
      "id": "van-dongen-2003",
      "title": "The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation",
      "authors": "Hans P. A. Van Dongen · Greg Maislin · Janet M. Mullington · David F. Dinges",
      "journal": "Sleep",
      "year": "2003",
      "url": "https://pubmed.ncbi.nlm.nih.gov/12683469/",
      "doi": "10.1093/sleep/26.2.117",
      "pmid": "12683469"
    },
    "references": [
      {
        "id": "van-dongen-2003",
        "title": "The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation",
        "authors": "Hans P. A. Van Dongen · Greg Maislin · Janet M. Mullington · David F. Dinges",
        "journal": "Sleep",
        "year": "2003",
        "url": "https://pubmed.ncbi.nlm.nih.gov/12683469/",
        "doi": "10.1093/sleep/26.2.117",
        "pmid": "12683469"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "What the study found",
        "paragraphs": [
          "This study examines neurobehavioural and sleep-physiology changes during repeated sleep restriction and total sleep deprivation. This record currently provides the original-source and erratum entry points. Detailed estimates, model equations and quantitative interpretation are deferred until the formal 2004 erratum is checked."
        ]
      },
      {
        "id": "limits",
        "title": "Scope & limitations",
        "paragraphs": [
          "Controlled experiments in healthy adults; this edition primarily provides a bibliographic record and correction notice.",
          "PubMed confirms an erratum in Sleep 2004;27(4):600, but its text has not been obtained. The available 2003 PDF predates it. The correction cannot be assumed to be typographical or numerically immaterial, and the model is not used here to prescribe individual sleep duration."
        ]
      },
      {
        "id": "sample",
        "title": "Population & sample",
        "paragraphs": [
          "Controlled experiments in healthy adults; this edition primarily provides a bibliographic record and correction notice."
        ]
      },
      {
        "id": "exposure",
        "title": "Exposure or intervention",
        "paragraphs": [
          "Repeated restriction of sleep opportunity and total sleep deprivation, with baseline and recovery observations."
        ]
      },
      {
        "id": "outcomes",
        "title": "Outcomes",
        "paragraphs": [
          "Neurobehavioural performance, subjective sleepiness and sleep physiology; estimates and model parameters await correction reconciliation."
        ]
      },
      {
        "id": "duration",
        "title": "Time frame",
        "paragraphs": [
          "Consecutive-night laboratory experiments; this edition supplies no quantitative recovery timetable."
        ]
      },
      {
        "id": "funding",
        "title": "Research funding",
        "paragraphs": [
          "Not yet verified against the full text."
        ]
      },
      {
        "id": "conflicts",
        "title": "Research conflicts of interest",
        "paragraphs": [
          "Not yet verified against the full text."
        ]
      },
      {
        "id": "basis",
        "title": "Reading scope",
        "paragraphs": [
          "The 2003 original PDF and PubMed erratum association were consulted. The text of Sleep 2004;27(4):600 remains unavailable; this edition is a source entry with an explicit correction notice."
        ],
        "links": [
          {
            "label": "Erratum bibliographic record; notice text pending",
            "url": "https://pubmed.ncbi.nlm.nih.gov/12683469/"
          }
        ]
      }
    ]
  }
}