{
  "schemaVersion": 1,
  "capturedAt": "2026-09-14T08:27:22.724Z",
  "sha256": "2672a81f1af3ce586ca7862b41754d6de65d6f8ed290ebce6633bbd109eed831",
  "work": {
    "id": "TAP-RDN-0005",
    "kind": "note",
    "key": "mcewen-2011",
    "locale": "en",
    "path": "/research/mcewen-2011/",
    "title": "TAP reading note: Stress- and Allostasis-Induced Brain Plasticity",
    "description": "Discusses the relationships between stress, adaptation and brain plasticity.",
    "rights": "© The Allostasis Project. All rights reserved. Reproduction or adaptation requires separate permission, subject to applicable legal exceptions.",
    "version": "0.1",
    "updatedAt": "2026-09-14",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-09-14",
      "version": "0.1",
      "author": null,
      "reviewer": null,
      "revisions": []
    },
    "original": {
      "id": "mcewen-2011",
      "title": "Stress- and Allostasis-Induced Brain Plasticity",
      "authors": "Bruce S. McEwen · Peter J. Gianaros",
      "journal": "Annual Review of Medicine",
      "year": "2011",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4251716/",
      "doi": "10.1146/annurev-med-052209-100430",
      "pmid": "20707675"
    },
    "references": [
      {
        "id": "mcewen-2011",
        "title": "Stress- and Allostasis-Induced Brain Plasticity",
        "authors": "Bruce S. McEwen · Peter J. Gianaros",
        "journal": "Annual Review of Medicine",
        "year": "2011",
        "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4251716/",
        "doi": "10.1146/annurev-med-052209-100430",
        "pmid": "20707675"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "What the study found",
        "paragraphs": [
          "Discusses the relationships between stress, adaptation and brain plasticity."
        ]
      },
      {
        "id": "limits",
        "title": "Scope & limitations",
        "paragraphs": [
          "Synthesis of human and animal research; no single trial sample",
          "The evidence spans species and study designs. Mechanistic findings cannot be directly generalised to the effects of a specific intervention in humans."
        ]
      },
      {
        "id": "sample",
        "title": "Population & sample",
        "paragraphs": [
          "Synthesis of human and animal research; no single trial sample"
        ]
      },
      {
        "id": "exposure",
        "title": "Exposure or intervention",
        "paragraphs": [
          "Stress and allostasis; human and animal literature"
        ]
      },
      {
        "id": "outcomes",
        "title": "Outcomes",
        "paragraphs": [
          "Brain plasticity and stress-related regulation"
        ]
      },
      {
        "id": "duration",
        "title": "Time frame",
        "paragraphs": [
          "No single observation period"
        ]
      },
      {
        "id": "funding",
        "title": "Research funding",
        "paragraphs": [
          "Not yet verified against the full text."
        ]
      },
      {
        "id": "conflicts",
        "title": "Research conflicts of interest",
        "paragraphs": [
          "Not yet verified against the full text."
        ]
      },
      {
        "id": "basis",
        "title": "Reading scope",
        "paragraphs": [
          "This selected reading note links to the original source. Bibliographic details have been checked; full-text verification is incomplete."
        ]
      }
    ],
    "type": "RDN"
  }
}