{
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  "capturedAt": "2026-10-29T10:31:13.621Z",
  "sha256": "ae03cdef1556781ee4644d378b8f225eed9b8017200eb92952296b1a8ee74789",
  "work": {
    "id": "TAP-RDN-0012",
    "type": "RDN",
    "kind": "note",
    "key": "ramsay-2014",
    "locale": "en",
    "path": "/research/ramsay-2014/",
    "title": "TAP reading note: Clarifying the roles of homeostasis and allostasis in physiological regulation",
    "description": "Ramsay and Woods examine homeostasis and allostasis through specific mechanisms: feedback and feedforward control, coordination between effectors, and dysregulation through overshoot, persistent activation or competing effectors. Their account helps turn a terminology debate into physiological questions that can be specified.",
    "rights": "© The Allostasis Project. All rights reserved. Reproduction or adaptation requires separate permission, subject to applicable legal exceptions.",
    "version": "0.3",
    "updatedAt": "2026-10-29",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-10-29",
      "version": "0.3",
      "author": null,
      "reviewer": null,
      "workflow": {
        "ai": {
          "usage": "used",
          "system": "OpenAI Codex",
          "scope": "Assisted source comparison, evidence extraction and bilingual research-note preparation. The materials consulted and unresolved scientific issues are specified in each note.",
          "version": "0.3",
          "tasks": [
            "Source comparison and evidence extraction",
            "Bilingual research-note drafting and editorial comparison"
          ]
        }
      },
      "revisions": [
        {
          "date": "2026-10-27",
          "version": "0.2",
          "description": "Reframed scope in terms of study design, population, outcomes and observation window."
        },
        {
          "date": "2026-10-29",
          "version": "0.3",
          "description": "Added effector mechanisms, terminological disagreement and the scope of the conceptual account."
        }
      ]
    },
    "original": {
      "id": "ramsay-2014",
      "title": "Clarifying the roles of homeostasis and allostasis in physiological regulation",
      "authors": "Ramsay DS · Woods SC",
      "journal": "Psychological review",
      "year": "2014",
      "url": "https://doi.org/10.1037/a0035942",
      "doi": "10.1037/a0035942",
      "pmid": "24730599"
    },
    "references": [
      {
        "id": "ramsay-2014",
        "title": "Clarifying the roles of homeostasis and allostasis in physiological regulation",
        "authors": "Ramsay DS · Woods SC",
        "journal": "Psychological review",
        "year": "2014",
        "url": "https://doi.org/10.1037/a0035942",
        "doi": "10.1037/a0035942",
        "pmid": "24730599"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "What the study found",
        "paragraphs": [
          "Ramsay and Woods examine homeostasis and allostasis through specific mechanisms: feedback and feedforward control, coordination between effectors, and dysregulation through overshoot, persistent activation or competing effectors. Their account helps turn a terminology debate into physiological questions that can be specified."
        ]
      },
      {
        "id": "limits",
        "title": "Scope & limitations",
        "paragraphs": [
          "Physiological theory and experimental literature; no new clinical sample.",
          "This is a conceptual critique, and its definition of allostasis differs from other accounts. Mechanistic examples do not estimate intervention effects, and the authors' terminology should not be treated as a field-wide consensus."
        ]
      },
      {
        "id": "sample",
        "title": "Population & sample",
        "paragraphs": [
          "Physiological theory and experimental literature; no new clinical sample."
        ]
      },
      {
        "id": "exposure",
        "title": "Exposure or intervention",
        "paragraphs": [
          "Comparison of feedback, feedforward and effector circuits in homeostatic and allostatic explanations."
        ]
      },
      {
        "id": "outcomes",
        "title": "Outcomes",
        "paragraphs": [
          "Conceptual distinctions and mechanistic explanations; no pooled clinical effect."
        ]
      },
      {
        "id": "duration",
        "title": "Time frame",
        "paragraphs": [
          "Multiple regulatory time scales; no common follow-up period."
        ]
      },
      {
        "id": "funding",
        "title": "Research funding",
        "paragraphs": [
          "NIH DA023484, DA033453 and DK017844."
        ]
      },
      {
        "id": "conflicts",
        "title": "Research conflicts of interest",
        "paragraphs": [
          "The separate competing-interest statement has not been fully checked."
        ]
      },
      {
        "id": "basis",
        "title": "Reading scope",
        "paragraphs": [
          "Focused reading of the full-text overview of allostasis and concluding arguments. The complete control-theory discussion and animal/drug examples have not been examined paragraph by paragraph."
        ],
        "links": [
          {
            "label": "Full text in PubMed Central",
            "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4166604/"
          }
        ]
      }
    ]
  }
}