{
  "schemaVersion": 1,
  "capturedAt": "2026-09-14T11:41:53.500Z",
  "sha256": "fa23ff2d61a23591c08ab1b4afe5bce851bd407b41fcd519525c6ce0f97e07f3",
  "work": {
    "id": "TAP-RDN-0013",
    "kind": "note",
    "key": "juster-2010",
    "locale": "en",
    "path": "/research/juster-2010/",
    "title": "TAP reading note: Allostatic load biomarkers of chronic stress and impact on health and cognition",
    "description": "This review connects the allostatic-load framework with neuroendocrine, immune, metabolic and cardiovascular measures, illustrating why cumulative physiological risk is studied across systems.",
    "rights": "© The Allostasis Project. All rights reserved. Reproduction or adaptation requires separate permission, subject to applicable legal exceptions.",
    "version": "0.1",
    "updatedAt": "2026-09-14",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-09-14",
      "version": "0.1",
      "author": null,
      "reviewer": null,
      "revisions": []
    },
    "original": {
      "id": "juster-2010",
      "title": "Allostatic load biomarkers of chronic stress and impact on health and cognition",
      "authors": "Robert-Paul Juster · Bruce S. McEwen · Sonia J. Lupien",
      "journal": "Neuroscience & Biobehavioral Reviews",
      "year": "2010",
      "url": "https://doi.org/10.1016/j.neubiorev.2009.10.002",
      "doi": "10.1016/j.neubiorev.2009.10.002",
      "pmid": "19822172"
    },
    "references": [
      {
        "id": "juster-2010",
        "title": "Allostatic load biomarkers of chronic stress and impact on health and cognition",
        "authors": "Robert-Paul Juster · Bruce S. McEwen · Sonia J. Lupien",
        "journal": "Neuroscience & Biobehavioral Reviews",
        "year": "2010",
        "url": "https://doi.org/10.1016/j.neubiorev.2009.10.002",
        "doi": "10.1016/j.neubiorev.2009.10.002",
        "pmid": "19822172"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "What the study found",
        "paragraphs": [
          "This review connects the allostatic-load framework with neuroendocrine, immune, metabolic and cardiovascular measures, illustrating why cumulative physiological risk is studied across systems."
        ]
      },
      {
        "id": "limits",
        "title": "Scope & limitations",
        "paragraphs": [
          "Review of theoretical and empirical stress, health and cognition research; no single trial sample.",
          "The measures discussed differ in meaning and collection methods. A list of biomarkers is not a standardized clinical panel, and this review cannot identify the cause of an individual symptom."
        ]
      },
      {
        "id": "sample",
        "title": "Population & sample",
        "paragraphs": [
          "Review of theoretical and empirical stress, health and cognition research; no single trial sample."
        ]
      },
      {
        "id": "exposure",
        "title": "Exposure or intervention",
        "paragraphs": [
          "Chronic stress, risk and protective factors, and multisystem biomarker indices."
        ]
      },
      {
        "id": "outcomes",
        "title": "Outcomes",
        "paragraphs": [
          "Physical and mental health, cognition and cumulative physiological risk."
        ]
      },
      {
        "id": "duration",
        "title": "Time frame",
        "paragraphs": [
          "Literature synthesis published in 2010; time windows vary across the underlying studies."
        ]
      },
      {
        "id": "funding",
        "title": "Research funding",
        "paragraphs": [
          "Not yet checked against the full publication."
        ]
      },
      {
        "id": "conflicts",
        "title": "Research conflicts of interest",
        "paragraphs": [
          "Not yet checked against the full publication."
        ]
      },
      {
        "id": "basis",
        "title": "Reading scope",
        "paragraphs": [
          "Based on the original publication’s abstract and bibliographic record. This is a selected reading note, not a systematic appraisal."
        ]
      }
    ],
    "type": "RDN"
  }
}