{
  "schemaVersion": 1,
  "capturedAt": "2026-09-14T11:41:53.506Z",
  "sha256": "4107b66c494999fadfe0f5545385d98f1457fca4f40fa9b868010ca41b413e89",
  "work": {
    "id": "TAP-RDN-0013",
    "kind": "note",
    "key": "juster-2010",
    "locale": "zh",
    "path": "/zh/research/juster-2010/",
    "title": "TAP 导读: Allostatic load biomarkers of chronic stress and impact on health and cognition",
    "description": "这篇综述把适应负荷框架与神经内分泌、免疫、代谢和心血管指标连接起来，解释研究者为何跨多个系统考察累积生理风险。",
    "rights": "© The Allostasis Project。保留所有权利。除法律允许的例外外，转载或改编需另行授权。",
    "version": "0.1",
    "updatedAt": "2026-09-14",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-09-14",
      "version": "0.1",
      "author": null,
      "reviewer": null,
      "revisions": []
    },
    "original": {
      "id": "juster-2010",
      "title": "Allostatic load biomarkers of chronic stress and impact on health and cognition",
      "authors": "Robert-Paul Juster · Bruce S. McEwen · Sonia J. Lupien",
      "journal": "Neuroscience & Biobehavioral Reviews",
      "year": "2010",
      "url": "https://doi.org/10.1016/j.neubiorev.2009.10.002",
      "doi": "10.1016/j.neubiorev.2009.10.002",
      "pmid": "19822172"
    },
    "references": [
      {
        "id": "juster-2010",
        "title": "Allostatic load biomarkers of chronic stress and impact on health and cognition",
        "authors": "Robert-Paul Juster · Bruce S. McEwen · Sonia J. Lupien",
        "journal": "Neuroscience & Biobehavioral Reviews",
        "year": "2010",
        "url": "https://doi.org/10.1016/j.neubiorev.2009.10.002",
        "doi": "10.1016/j.neubiorev.2009.10.002",
        "pmid": "19822172"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "研究发现",
        "paragraphs": [
          "这篇综述把适应负荷框架与神经内分泌、免疫、代谢和心血管指标连接起来，解释研究者为何跨多个系统考察累积生理风险。"
        ]
      },
      {
        "id": "limits",
        "title": "范围与局限",
        "paragraphs": [
          "压力、健康与认知领域的理论及实证研究综述；没有单一试验样本。",
          "所讨论指标的含义和采集方法不同。指标清单不是统一临床检测方案，也不能用来确定某个人症状的原因。"
        ]
      },
      {
        "id": "sample",
        "title": "研究人群与样本",
        "paragraphs": [
          "压力、健康与认知领域的理论及实证研究综述；没有单一试验样本。"
        ]
      },
      {
        "id": "exposure",
        "title": "暴露或干预",
        "paragraphs": [
          "慢性压力、风险与保护因素，以及多系统生物指标组合。"
        ]
      },
      {
        "id": "outcomes",
        "title": "观察结局",
        "paragraphs": [
          "身体与心理健康、认知及累积生理风险。"
        ]
      },
      {
        "id": "duration",
        "title": "时间范围",
        "paragraphs": [
          "2010 年发表的文献整合；各原始研究的观察时间不同。"
        ]
      },
      {
        "id": "funding",
        "title": "研究资金来源",
        "paragraphs": [
          "尚未根据完整论文核查。"
        ]
      },
      {
        "id": "conflicts",
        "title": "研究利益关系",
        "paragraphs": [
          "尚未根据完整论文核查。"
        ]
      },
      {
        "id": "basis",
        "title": "导读范围",
        "paragraphs": [
          "依据原论文摘要与书目记录撰写的精选导读，未进行系统证据评价。"
        ]
      }
    ],
    "type": "RDN"
  }
}