{
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  "capturedAt": "2026-10-27T11:18:42.891Z",
  "sha256": "25c16d7633a055544d32c065f7c50478ddaedcfbf817ca3ddb7112bc6e7f4bdd",
  "work": {
    "id": "TAP-RDN-0013",
    "type": "RDN",
    "kind": "note",
    "key": "juster-2010",
    "locale": "zh",
    "path": "/zh/research/juster-2010/",
    "title": "TAP 导读: Allostatic load biomarkers of chronic stress and impact on health and cognition",
    "description": "这篇综述把适应负荷框架与神经内分泌、免疫、代谢和心血管指标连接起来，解释研究者为何跨多个系统考察累积生理风险。",
    "rights": "© The Allostasis Project。保留所有权利。除法律允许的例外外，转载或改编需另行授权。",
    "version": "0.2",
    "updatedAt": "2026-10-27",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-10-27",
      "version": "0.2",
      "author": null,
      "reviewer": null,
      "workflow": {
        "ai": {
          "usage": "used",
          "system": "TAP Research Agent / OpenAI Codex",
          "scope": "基于已发布正文的中英文表达修订与范围说明整理。",
          "version": "0.2",
          "tasks": [
            "中英文编辑",
            "范围说明与引用位置对照"
          ]
        }
      },
      "revisions": [
        {
          "date": "2026-10-27",
          "version": "0.2",
          "description": "按研究设计、人群、结局与观察窗口重写适用范围说明。"
        }
      ]
    },
    "original": {
      "id": "juster-2010",
      "title": "Allostatic load biomarkers of chronic stress and impact on health and cognition",
      "authors": "Robert-Paul Juster · Bruce S. McEwen · Sonia J. Lupien",
      "journal": "Neuroscience & Biobehavioral Reviews",
      "year": "2010",
      "url": "https://doi.org/10.1016/j.neubiorev.2009.10.002",
      "doi": "10.1016/j.neubiorev.2009.10.002",
      "pmid": "19822172"
    },
    "references": [
      {
        "id": "juster-2010",
        "title": "Allostatic load biomarkers of chronic stress and impact on health and cognition",
        "authors": "Robert-Paul Juster · Bruce S. McEwen · Sonia J. Lupien",
        "journal": "Neuroscience & Biobehavioral Reviews",
        "year": "2010",
        "url": "https://doi.org/10.1016/j.neubiorev.2009.10.002",
        "doi": "10.1016/j.neubiorev.2009.10.002",
        "pmid": "19822172"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "研究发现",
        "paragraphs": [
          "这篇综述把适应负荷框架与神经内分泌、免疫、代谢和心血管指标连接起来，解释研究者为何跨多个系统考察累积生理风险。"
        ]
      },
      {
        "id": "limits",
        "title": "范围与局限",
        "paragraphs": [
          "压力、健康与认知领域的理论及实证研究综述；没有单一试验样本。",
          "综述涵盖含义和采集方法不同的指标。采用某种组合时，需要明确取样条件、指标选择及其与目标结局的关系。"
        ]
      },
      {
        "id": "sample",
        "title": "研究人群与样本",
        "paragraphs": [
          "压力、健康与认知领域的理论及实证研究综述；没有单一试验样本。"
        ]
      },
      {
        "id": "exposure",
        "title": "暴露或干预",
        "paragraphs": [
          "慢性压力、风险与保护因素，以及多系统生物指标组合。"
        ]
      },
      {
        "id": "outcomes",
        "title": "观察结局",
        "paragraphs": [
          "身体与心理健康、认知及累积生理风险。"
        ]
      },
      {
        "id": "duration",
        "title": "时间范围",
        "paragraphs": [
          "2010 年发表的文献整合；各原始研究的观察时间不同。"
        ]
      },
      {
        "id": "funding",
        "title": "研究资金来源",
        "paragraphs": [
          "尚未根据完整论文核查。"
        ]
      },
      {
        "id": "conflicts",
        "title": "研究利益关系",
        "paragraphs": [
          "尚未根据完整论文核查。"
        ]
      },
      {
        "id": "basis",
        "title": "导读范围",
        "paragraphs": [
          "依据原论文摘要与书目记录撰写的精选导读，未进行系统证据评价。"
        ]
      }
    ]
  }
}