{
  "schemaVersion": 1,
  "capturedAt": "2026-09-14T11:37:40.853Z",
  "sha256": "f645bf5fe6c3e52cf88e0409caf90ab6eb8f283984edbc1563e0e282ca261fb8",
  "work": {
    "id": "TAP-RDN-0014",
    "kind": "note",
    "key": "mccrory-2023",
    "locale": "en",
    "path": "/research/mccrory-2023/",
    "title": "TAP reading note: Towards a consensus definition of allostatic load: a multi-cohort, multi-system, multi-biomarker individual participant data (IPD) meta-analysis",
    "description": "Across 13 cohorts, the authors compared biomarker associations with function and self-rated health. A five-marker index performed as well as or better than more elaborate combinations for mortality prediction in the analyses reported.",
    "rights": "© The Allostasis Project. All rights reserved. Reproduction or adaptation requires separate permission, subject to applicable legal exceptions.",
    "version": "0.1",
    "updatedAt": "2026-09-14",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-09-14",
      "version": "0.1",
      "author": null,
      "reviewer": null,
      "revisions": []
    },
    "original": {
      "id": "mccrory-2023",
      "title": "Towards a consensus definition of allostatic load: a multi-cohort, multi-system, multi-biomarker individual participant data (IPD) meta-analysis",
      "authors": "Cathal McCrory · Sinead McLoughlin · Richard Layte · Cliona NiCheallaigh · Aisling M. O’Halloran · Henrique Barros · Lisa F. Berkman · Murielle Bochud · Eileen M. Crimmins · Meagan T. Farrell · Silvia Fraga · Emily Grundy · Michelle Kelly-Irving · Dusan Petrovic · Teresa Seeman · Silvia Stringhini · Peter Vollenveider · Rose Anne Kenny",
      "journal": "Psychoneuroendocrinology",
      "year": "2023",
      "url": "https://doi.org/10.1016/j.psyneuen.2023.106117",
      "doi": "10.1016/j.psyneuen.2023.106117",
      "pmid": "37100008"
    },
    "references": [
      {
        "id": "mccrory-2023",
        "title": "Towards a consensus definition of allostatic load: a multi-cohort, multi-system, multi-biomarker individual participant data (IPD) meta-analysis",
        "authors": "Cathal McCrory · Sinead McLoughlin · Richard Layte · Cliona NiCheallaigh · Aisling M. O’Halloran · Henrique Barros · Lisa F. Berkman · Murielle Bochud · Eileen M. Crimmins · Meagan T. Farrell · Silvia Fraga · Emily Grundy · Michelle Kelly-Irving · Dusan Petrovic · Teresa Seeman · Silvia Stringhini · Peter Vollenveider · Rose Anne Kenny",
        "journal": "Psychoneuroendocrinology",
        "year": "2023",
        "url": "https://doi.org/10.1016/j.psyneuen.2023.106117",
        "doi": "10.1016/j.psyneuen.2023.106117",
        "pmid": "37100008"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "What the study found",
        "paragraphs": [
          "Across 13 cohorts, the authors compared biomarker associations with function and self-rated health. A five-marker index performed as well as or better than more elaborate combinations for mortality prediction in the analyses reported."
        ]
      },
      {
        "id": "limits",
        "title": "Scope & limitations",
        "paragraphs": [
          "Individual-participant-data analysis of 67,126 people aged 40–111 years; 40 candidate biomarkers across 12 physiological systems.",
          "This is evidence for harmonizing measurement in the cohorts examined. It does not establish a universal diagnostic threshold, prove that stress caused every biomarker difference, or show that lowering an index improves health."
        ]
      },
      {
        "id": "sample",
        "title": "Population & sample",
        "paragraphs": [
          "Individual-participant-data analysis of 67,126 people aged 40–111 years; 40 candidate biomarkers across 12 physiological systems."
        ]
      },
      {
        "id": "exposure",
        "title": "Exposure or intervention",
        "paragraphs": [
          "Alternative biomarker combinations used to operationalize allostatic load."
        ]
      },
      {
        "id": "outcomes",
        "title": "Outcomes",
        "paragraphs": [
          "Grip strength, walking speed and self-rated health; mortality used as a separate outcome."
        ]
      },
      {
        "id": "duration",
        "title": "Time frame",
        "paragraphs": [
          "Multiple cohorts with differing observation periods; published in 2023."
        ]
      },
      {
        "id": "funding",
        "title": "Research funding",
        "paragraphs": [
          "Not yet checked against the full publication."
        ]
      },
      {
        "id": "conflicts",
        "title": "Research conflicts of interest",
        "paragraphs": [
          "Not yet checked against the full publication."
        ]
      },
      {
        "id": "basis",
        "title": "Reading scope",
        "paragraphs": [
          "Based on the original publication’s abstract and bibliographic record. This is a selected reading note, not a systematic appraisal."
        ]
      }
    ],
    "type": "RDN"
  }
}