{
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  "capturedAt": "2026-10-27T11:18:42.872Z",
  "sha256": "c96b3dbe295a694cb0e343e6a04e4832ffa1322650421e55d0870293a48161a0",
  "work": {
    "id": "TAP-RDN-0014",
    "type": "RDN",
    "kind": "note",
    "key": "mccrory-2023",
    "locale": "en",
    "path": "/research/mccrory-2023/",
    "title": "TAP reading note: Towards a consensus definition of allostatic load: a multi-cohort, multi-system, multi-biomarker individual participant data (IPD) meta-analysis",
    "description": "Across 13 cohorts, the authors compared biomarker associations with function and self-rated health. A five-marker index performed as well as or better than more elaborate combinations for mortality prediction in the analyses reported.",
    "rights": "© The Allostasis Project. All rights reserved. Reproduction or adaptation requires separate permission, subject to applicable legal exceptions.",
    "version": "0.2",
    "updatedAt": "2026-10-27",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-10-27",
      "version": "0.2",
      "author": null,
      "reviewer": null,
      "workflow": {
        "ai": {
          "usage": "used",
          "system": "TAP Research Agent / OpenAI Codex",
          "scope": "Bilingual editorial revision and consolidation of scope statements based on the published text.",
          "version": "0.2",
          "tasks": [
            "Bilingual editing",
            "Scope and citation-position comparison"
          ]
        }
      },
      "revisions": [
        {
          "date": "2026-10-27",
          "version": "0.2",
          "description": "Reframed scope in terms of study design, population, outcomes and observation window."
        }
      ]
    },
    "original": {
      "id": "mccrory-2023",
      "title": "Towards a consensus definition of allostatic load: a multi-cohort, multi-system, multi-biomarker individual participant data (IPD) meta-analysis",
      "authors": "Cathal McCrory · Sinead McLoughlin · Richard Layte · Cliona NiCheallaigh · Aisling M. O’Halloran · Henrique Barros · Lisa F. Berkman · Murielle Bochud · Eileen M. Crimmins · Meagan T. Farrell · Silvia Fraga · Emily Grundy · Michelle Kelly-Irving · Dusan Petrovic · Teresa Seeman · Silvia Stringhini · Peter Vollenveider · Rose Anne Kenny",
      "journal": "Psychoneuroendocrinology",
      "year": "2023",
      "url": "https://doi.org/10.1016/j.psyneuen.2023.106117",
      "doi": "10.1016/j.psyneuen.2023.106117",
      "pmid": "37100008"
    },
    "references": [
      {
        "id": "mccrory-2023",
        "title": "Towards a consensus definition of allostatic load: a multi-cohort, multi-system, multi-biomarker individual participant data (IPD) meta-analysis",
        "authors": "Cathal McCrory · Sinead McLoughlin · Richard Layte · Cliona NiCheallaigh · Aisling M. O’Halloran · Henrique Barros · Lisa F. Berkman · Murielle Bochud · Eileen M. Crimmins · Meagan T. Farrell · Silvia Fraga · Emily Grundy · Michelle Kelly-Irving · Dusan Petrovic · Teresa Seeman · Silvia Stringhini · Peter Vollenveider · Rose Anne Kenny",
        "journal": "Psychoneuroendocrinology",
        "year": "2023",
        "url": "https://doi.org/10.1016/j.psyneuen.2023.106117",
        "doi": "10.1016/j.psyneuen.2023.106117",
        "pmid": "37100008"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "What the study found",
        "paragraphs": [
          "Across 13 cohorts, the authors compared biomarker associations with function and self-rated health. A five-marker index performed as well as or better than more elaborate combinations for mortality prediction in the analyses reported."
        ]
      },
      {
        "id": "limits",
        "title": "Scope & limitations",
        "paragraphs": [
          "Individual-participant-data analysis of 67,126 people aged 40–111 years; 40 candidate biomarkers across 12 physiological systems.",
          "The findings inform biomarker harmonization in the cohorts and outcomes studied. Extension to other populations, diagnosis or intervention evaluation requires assessment of performance and applicability."
        ]
      },
      {
        "id": "sample",
        "title": "Population & sample",
        "paragraphs": [
          "Individual-participant-data analysis of 67,126 people aged 40–111 years; 40 candidate biomarkers across 12 physiological systems."
        ]
      },
      {
        "id": "exposure",
        "title": "Exposure or intervention",
        "paragraphs": [
          "Alternative biomarker combinations used to operationalize allostatic load."
        ]
      },
      {
        "id": "outcomes",
        "title": "Outcomes",
        "paragraphs": [
          "Grip strength, walking speed and self-rated health; mortality used as a separate outcome."
        ]
      },
      {
        "id": "duration",
        "title": "Time frame",
        "paragraphs": [
          "Multiple cohorts with differing observation periods; published in 2023."
        ]
      },
      {
        "id": "funding",
        "title": "Research funding",
        "paragraphs": [
          "Not yet checked against the full publication."
        ]
      },
      {
        "id": "conflicts",
        "title": "Research conflicts of interest",
        "paragraphs": [
          "Not yet checked against the full publication."
        ]
      },
      {
        "id": "basis",
        "title": "Reading scope",
        "paragraphs": [
          "Based on the original publication’s abstract and bibliographic record. This is a selected reading note, not a systematic appraisal."
        ]
      }
    ]
  }
}