{
  "schemaVersion": 1,
  "capturedAt": "2026-09-14T11:37:40.862Z",
  "sha256": "df138b7b0865966c68c054af811db7d34f9e7d674c27084b4f510bc2379cb1b0",
  "work": {
    "id": "TAP-RDN-0014",
    "kind": "note",
    "key": "mccrory-2023",
    "locale": "zh",
    "path": "/zh/research/mccrory-2023/",
    "title": "TAP 导读: Towards a consensus definition of allostatic load: a multi-cohort, multi-system, multi-biomarker individual participant data (IPD) meta-analysis",
    "description": "作者在 13 个队列中比较了生物指标与功能、自评健康的关联。报告的分析中，一个五指标组合对死亡结局的预测表现，与更复杂的组合相当或更好。",
    "rights": "© The Allostasis Project。保留所有权利。除法律允许的例外外，转载或改编需另行授权。",
    "version": "0.1",
    "updatedAt": "2026-09-14",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-09-14",
      "version": "0.1",
      "author": null,
      "reviewer": null,
      "revisions": []
    },
    "original": {
      "id": "mccrory-2023",
      "title": "Towards a consensus definition of allostatic load: a multi-cohort, multi-system, multi-biomarker individual participant data (IPD) meta-analysis",
      "authors": "Cathal McCrory · Sinead McLoughlin · Richard Layte · Cliona NiCheallaigh · Aisling M. O’Halloran · Henrique Barros · Lisa F. Berkman · Murielle Bochud · Eileen M. Crimmins · Meagan T. Farrell · Silvia Fraga · Emily Grundy · Michelle Kelly-Irving · Dusan Petrovic · Teresa Seeman · Silvia Stringhini · Peter Vollenveider · Rose Anne Kenny",
      "journal": "Psychoneuroendocrinology",
      "year": "2023",
      "url": "https://doi.org/10.1016/j.psyneuen.2023.106117",
      "doi": "10.1016/j.psyneuen.2023.106117",
      "pmid": "37100008"
    },
    "references": [
      {
        "id": "mccrory-2023",
        "title": "Towards a consensus definition of allostatic load: a multi-cohort, multi-system, multi-biomarker individual participant data (IPD) meta-analysis",
        "authors": "Cathal McCrory · Sinead McLoughlin · Richard Layte · Cliona NiCheallaigh · Aisling M. O’Halloran · Henrique Barros · Lisa F. Berkman · Murielle Bochud · Eileen M. Crimmins · Meagan T. Farrell · Silvia Fraga · Emily Grundy · Michelle Kelly-Irving · Dusan Petrovic · Teresa Seeman · Silvia Stringhini · Peter Vollenveider · Rose Anne Kenny",
        "journal": "Psychoneuroendocrinology",
        "year": "2023",
        "url": "https://doi.org/10.1016/j.psyneuen.2023.106117",
        "doi": "10.1016/j.psyneuen.2023.106117",
        "pmid": "37100008"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "研究发现",
        "paragraphs": [
          "作者在 13 个队列中比较了生物指标与功能、自评健康的关联。报告的分析中，一个五指标组合对死亡结局的预测表现，与更复杂的组合相当或更好。"
        ]
      },
      {
        "id": "limits",
        "title": "范围与局限",
        "paragraphs": [
          "个体参与者数据分析：67,126 名 40–111 岁参与者；比较涉及 12 个生理系统的 40 项候选指标。",
          "这为所研究队列中的测量协调提供依据，并未建立通用诊断阈值，也不能证明所有指标差异均由压力造成，或降低分数就能改善健康。"
        ]
      },
      {
        "id": "sample",
        "title": "研究人群与样本",
        "paragraphs": [
          "个体参与者数据分析：67,126 名 40–111 岁参与者；比较涉及 12 个生理系统的 40 项候选指标。"
        ]
      },
      {
        "id": "exposure",
        "title": "暴露或干预",
        "paragraphs": [
          "用于操作化适应负荷的不同生物指标组合。"
        ]
      },
      {
        "id": "outcomes",
        "title": "观察结局",
        "paragraphs": [
          "握力、步行速度、自评健康；另以死亡作为结局考察预测表现。"
        ]
      },
      {
        "id": "duration",
        "title": "时间范围",
        "paragraphs": [
          "多个队列的观察期不同；论文发表于 2023 年。"
        ]
      },
      {
        "id": "funding",
        "title": "研究资金来源",
        "paragraphs": [
          "尚未根据完整论文核查。"
        ]
      },
      {
        "id": "conflicts",
        "title": "研究利益关系",
        "paragraphs": [
          "尚未根据完整论文核查。"
        ]
      },
      {
        "id": "basis",
        "title": "导读范围",
        "paragraphs": [
          "依据原论文摘要与书目记录撰写的精选导读，未进行系统证据评价。"
        ]
      }
    ],
    "type": "RDN"
  }
}