{
  "schemaVersion": 1,
  "capturedAt": "2026-10-29T10:31:13.715Z",
  "sha256": "2518b8e7d33d8f32de26404bb354c88a6e8e4e4482360275b4f4842f4bfc69f5",
  "work": {
    "id": "TAP-RDN-0014",
    "type": "RDN",
    "kind": "note",
    "key": "mccrory-2023",
    "locale": "zh",
    "path": "/zh/research/mccrory-2023/",
    "title": "TAP 导读: Towards a consensus definition of allostatic load: a multi-cohort, multi-system, multi-biomarker individual participant data (IPD) meta-analysis",
    "description": "这项跨队列分析尝试缩小适应负荷指标的选择范围。CRP、静息心率、HDL胆固醇、腰高比和HbA1c组成的五项组合，在研究内的死亡预测表现与更长组合相近；加入呼气峰流量还可能提供额外信息。它提出了协调测量的候选指标集。",
    "rights": "© The Allostasis Project。保留所有权利。除法律允许的例外外，转载或改编需另行授权。",
    "version": "0.3",
    "updatedAt": "2026-10-29",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-10-29",
      "version": "0.3",
      "author": null,
      "reviewer": null,
      "workflow": {
        "ai": {
          "usage": "used",
          "system": "OpenAI Codex",
          "scope": "Assisted source comparison, evidence extraction and bilingual research-note preparation. The materials consulted and unresolved scientific issues are specified in each note.",
          "version": "0.3",
          "tasks": [
            "Source comparison and evidence extraction",
            "Bilingual research-note drafting and editorial comparison"
          ]
        }
      },
      "revisions": [
        {
          "date": "2026-10-27",
          "version": "0.2",
          "description": "按研究设计、人群、结局与观察窗口重写适用范围说明。"
        },
        {
          "date": "2026-10-29",
          "version": "0.3",
          "description": "补充13队列的指标选择、死亡分析口径及五项组合的适用边界。"
        }
      ]
    },
    "original": {
      "id": "mccrory-2023",
      "title": "Towards a consensus definition of allostatic load: a multi-cohort, multi-system, multi-biomarker individual participant data (IPD) meta-analysis",
      "authors": "Cathal McCrory · Sinead McLoughlin · Richard Layte · Cliona NiCheallaigh · Aisling M. O’Halloran · Henrique Barros · Lisa F. Berkman · Murielle Bochud · Eileen M. Crimmins · Meagan T. Farrell · Silvia Fraga · Emily Grundy · Michelle Kelly-Irving · Dusan Petrovic · Teresa Seeman · Silvia Stringhini · Peter Vollenveider · Rose Anne Kenny",
      "journal": "Psychoneuroendocrinology",
      "year": "2023",
      "url": "https://doi.org/10.1016/j.psyneuen.2023.106117",
      "doi": "10.1016/j.psyneuen.2023.106117",
      "pmid": "37100008"
    },
    "references": [
      {
        "id": "mccrory-2023",
        "title": "Towards a consensus definition of allostatic load: a multi-cohort, multi-system, multi-biomarker individual participant data (IPD) meta-analysis",
        "authors": "Cathal McCrory · Sinead McLoughlin · Richard Layte · Cliona NiCheallaigh · Aisling M. O’Halloran · Henrique Barros · Lisa F. Berkman · Murielle Bochud · Eileen M. Crimmins · Meagan T. Farrell · Silvia Fraga · Emily Grundy · Michelle Kelly-Irving · Dusan Petrovic · Teresa Seeman · Silvia Stringhini · Peter Vollenveider · Rose Anne Kenny",
        "journal": "Psychoneuroendocrinology",
        "year": "2023",
        "url": "https://doi.org/10.1016/j.psyneuen.2023.106117",
        "doi": "10.1016/j.psyneuen.2023.106117",
        "pmid": "37100008"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "研究发现",
        "paragraphs": [
          "这项跨队列分析尝试缩小适应负荷指标的选择范围。CRP、静息心率、HDL胆固醇、腰高比和HbA1c组成的五项组合，在研究内的死亡预测表现与更长组合相近；加入呼气峰流量还可能提供额外信息。它提出了协调测量的候选指标集。"
        ]
      },
      {
        "id": "limits",
        "title": "范围与局限",
        "paragraphs": [
          "13个队列、67,126名40—111岁参与者；死亡资料来自其中10个队列。",
          "队列按资料可得性选择；健康结局多为横断面，死亡随访长短不同。按健康结局筛选指标，并未证明它们对心理压力特异，也未给出可直接用于个人诊断的统一截点。年轻人群、性别差异、用药影响和外部校准仍需研究。"
        ]
      },
      {
        "id": "sample",
        "title": "研究人群与样本",
        "paragraphs": [
          "13个队列、67,126名40—111岁参与者；死亡资料来自其中10个队列。"
        ]
      },
      {
        "id": "exposure",
        "title": "暴露或干预",
        "paragraphs": [
          "比较12个生理系统的40项标志物及不同长度的组合；采用两阶段个体参与者数据荟萃分析。"
        ]
      },
      {
        "id": "outcomes",
        "title": "观察结局",
        "paragraphs": [
          "健康功能指标及死亡；死亡资料按二分类结局分析，未统一为相同随访长度的生存模型。"
        ]
      },
      {
        "id": "duration",
        "title": "时间范围",
        "paragraphs": [
          "死亡随访因队列而异，约2—14年；其他主要健康指标为横断面。"
        ]
      },
      {
        "id": "funding",
        "title": "研究资金来源",
        "paragraphs": [
          "包括爱尔兰Health Research Board EIA-2017-012、英国ESRC ES/T014083/1及ERC Gendhi项目等；各队列另有资助，部分涉及商业支持，完整清单见原文。"
        ]
      },
      {
        "id": "conflicts",
        "title": "研究利益关系",
        "paragraphs": [
          "独立利益声明及各队列全部披露尚未核全。"
        ]
      },
      {
        "id": "basis",
        "title": "导读范围",
        "paragraphs": [
          "依据作者版全文的研究人群、统计方法、五项指标比较及建议部分；附表S5/S6、外部校准与全部队列附件尚待核读。"
        ],
        "links": [
          {
            "label": "PubMed Central全文",
            "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10620736/"
          }
        ]
      }
    ]
  }
}