{
  "schemaVersion": 1,
  "capturedAt": "2026-09-14T11:37:40.854Z",
  "sha256": "4df2123ab18da08cda5b9bd35edbe60ee8b8ad6b79476392f4f70b2d330e4c29",
  "work": {
    "id": "TAP-RDN-0015",
    "kind": "note",
    "key": "parker-2022",
    "locale": "en",
    "path": "/research/parker-2022/",
    "title": "TAP reading note: Allostatic Load and Mortality: A Systematic Review and Meta-Analysis",
    "description": "Higher allostatic load was associated with higher all-cause and cardiovascular mortality in pooled observational evidence. The size of the association varied substantially between studies.",
    "rights": "© The Allostasis Project. All rights reserved. Reproduction or adaptation requires separate permission, subject to applicable legal exceptions.",
    "version": "0.1",
    "updatedAt": "2026-09-14",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-09-14",
      "version": "0.1",
      "author": null,
      "reviewer": null,
      "revisions": []
    },
    "original": {
      "id": "parker-2022",
      "title": "Allostatic Load and Mortality: A Systematic Review and Meta-Analysis",
      "authors": "Haley W. Parker · Alyssa M. Abreu · Mary C. Sullivan · Maya K. Vadiveloo",
      "journal": "American Journal of Preventive Medicine",
      "year": "2022",
      "url": "https://doi.org/10.1016/j.amepre.2022.02.003",
      "doi": "10.1016/j.amepre.2022.02.003",
      "pmid": "35393143"
    },
    "references": [
      {
        "id": "parker-2022",
        "title": "Allostatic Load and Mortality: A Systematic Review and Meta-Analysis",
        "authors": "Haley W. Parker · Alyssa M. Abreu · Mary C. Sullivan · Maya K. Vadiveloo",
        "journal": "American Journal of Preventive Medicine",
        "year": "2022",
        "url": "https://doi.org/10.1016/j.amepre.2022.02.003",
        "doi": "10.1016/j.amepre.2022.02.003",
        "pmid": "35393143"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "What the study found",
        "paragraphs": [
          "Higher allostatic load was associated with higher all-cause and cardiovascular mortality in pooled observational evidence. The size of the association varied substantially between studies."
        ]
      },
      {
        "id": "limits",
        "title": "Scope & limitations",
        "paragraphs": [
          "Systematic review of 17 eligible studies. Main pooled estimates used 10 studies for all-cause mortality and six for cardiovascular mortality.",
          "Most pooled estimates had very high heterogeneity (I² above 90%). The associations do not quantify an individual lifespan or the benefit of an intervention that changes an AL score."
        ]
      },
      {
        "id": "sample",
        "title": "Population & sample",
        "paragraphs": [
          "Systematic review of 17 eligible studies. Main pooled estimates used 10 studies for all-cause mortality and six for cardiovascular mortality."
        ]
      },
      {
        "id": "exposure",
        "title": "Exposure or intervention",
        "paragraphs": [
          "Higher versus lower allostatic load, as defined separately by each study."
        ]
      },
      {
        "id": "outcomes",
        "title": "Outcomes",
        "paragraphs": [
          "All-cause and cardiovascular mortality; these outcomes were synthesized separately."
        ]
      },
      {
        "id": "duration",
        "title": "Time frame",
        "paragraphs": [
          "Database searches in May 2021; eligible studies published from 2001 to 2020."
        ]
      },
      {
        "id": "funding",
        "title": "Research funding",
        "paragraphs": [
          "Not yet checked against the full publication."
        ]
      },
      {
        "id": "conflicts",
        "title": "Research conflicts of interest",
        "paragraphs": [
          "Not yet checked against the full publication."
        ]
      },
      {
        "id": "basis",
        "title": "Reading scope",
        "paragraphs": [
          "Based on the original publication’s abstract and bibliographic record. This is a selected reading note, not a systematic appraisal."
        ]
      }
    ],
    "type": "RDN"
  }
}