{
  "schemaVersion": 1,
  "capturedAt": "2026-09-14T11:37:40.862Z",
  "sha256": "88e6a30acd825d447ff5846db49e9894a1c05bc9aebb47ffda848a2ab8feb578",
  "work": {
    "id": "TAP-RDN-0015",
    "kind": "note",
    "key": "parker-2022",
    "locale": "zh",
    "path": "/zh/research/parker-2022/",
    "title": "TAP 导读: Allostatic Load and Mortality: A Systematic Review and Meta-Analysis",
    "description": "汇总的观察性证据显示，较高适应负荷与较高全因死亡及心血管死亡风险相关，但研究之间的关联大小存在明显差异。",
    "rights": "© The Allostasis Project。保留所有权利。除法律允许的例外外，转载或改编需另行授权。",
    "version": "0.1",
    "updatedAt": "2026-09-14",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-09-14",
      "version": "0.1",
      "author": null,
      "reviewer": null,
      "revisions": []
    },
    "original": {
      "id": "parker-2022",
      "title": "Allostatic Load and Mortality: A Systematic Review and Meta-Analysis",
      "authors": "Haley W. Parker · Alyssa M. Abreu · Mary C. Sullivan · Maya K. Vadiveloo",
      "journal": "American Journal of Preventive Medicine",
      "year": "2022",
      "url": "https://doi.org/10.1016/j.amepre.2022.02.003",
      "doi": "10.1016/j.amepre.2022.02.003",
      "pmid": "35393143"
    },
    "references": [
      {
        "id": "parker-2022",
        "title": "Allostatic Load and Mortality: A Systematic Review and Meta-Analysis",
        "authors": "Haley W. Parker · Alyssa M. Abreu · Mary C. Sullivan · Maya K. Vadiveloo",
        "journal": "American Journal of Preventive Medicine",
        "year": "2022",
        "url": "https://doi.org/10.1016/j.amepre.2022.02.003",
        "doi": "10.1016/j.amepre.2022.02.003",
        "pmid": "35393143"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "研究发现",
        "paragraphs": [
          "汇总的观察性证据显示，较高适应负荷与较高全因死亡及心血管死亡风险相关，但研究之间的关联大小存在明显差异。"
        ]
      },
      {
        "id": "limits",
        "title": "范围与局限",
        "paragraphs": [
          "系统综述纳入 17 项研究；主要合并估计中，全因死亡使用 10 项研究，心血管死亡使用 6 项研究。",
          "多数合并估计的异质性很高，I² 超过 90%。这些关联不能用于计算个人寿命，也不能估计某项降低 AL 分数的干预会带来多少收益。"
        ]
      },
      {
        "id": "sample",
        "title": "研究人群与样本",
        "paragraphs": [
          "系统综述纳入 17 项研究；主要合并估计中，全因死亡使用 10 项研究，心血管死亡使用 6 项研究。"
        ]
      },
      {
        "id": "exposure",
        "title": "暴露或干预",
        "paragraphs": [
          "各研究分别定义的较高与较低适应负荷。"
        ]
      },
      {
        "id": "outcomes",
        "title": "观察结局",
        "paragraphs": [
          "全因死亡和心血管死亡，分别进行证据合并。"
        ]
      },
      {
        "id": "duration",
        "title": "时间范围",
        "paragraphs": [
          "2021 年 5 月检索数据库；纳入研究发表于 2001–2020 年。"
        ]
      },
      {
        "id": "funding",
        "title": "研究资金来源",
        "paragraphs": [
          "尚未根据完整论文核查。"
        ]
      },
      {
        "id": "conflicts",
        "title": "研究利益关系",
        "paragraphs": [
          "尚未根据完整论文核查。"
        ]
      },
      {
        "id": "basis",
        "title": "导读范围",
        "paragraphs": [
          "依据原论文摘要与书目记录撰写的精选导读，未进行系统证据评价。"
        ]
      }
    ],
    "type": "RDN"
  }
}