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    "id": "TAP-RDN-0025",
    "type": "RDN",
    "kind": "note",
    "key": "depner-2019",
    "locale": "en",
    "path": "/research/depner-2019/",
    "title": "TAP reading note: Ad libitum Weekend Recovery Sleep Fails to Prevent Metabolic Dysregulation during a Repeating Pattern of Insufficient Sleep and Weekend Recovery Sleep",
    "description": "In this short laboratory protocol, two unrestricted weekend nights followed by renewed restriction did not prevent the observed metabolic dysregulation. Whole-body insulin sensitivity fell by approximately 13% and 27% from each group's own baseline in continuous restriction and weekend recovery respectively. Those within-group percentages do not establish a significant between-group difference.",
    "rights": "© The Allostasis Project. All rights reserved. Reproduction or adaptation requires separate permission, subject to applicable legal exceptions.",
    "version": "0.3",
    "updatedAt": "2026-10-29",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-10-29",
      "version": "0.3",
      "author": null,
      "reviewer": null,
      "workflow": {
        "ai": {
          "usage": "used",
          "system": "OpenAI Codex",
          "scope": "Assisted source comparison, evidence extraction and bilingual research-note preparation. The materials consulted and unresolved scientific issues are specified in each note.",
          "version": "0.3",
          "tasks": [
            "Source comparison and evidence extraction",
            "Bilingual research-note drafting and editorial comparison"
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      },
      "revisions": [
        {
          "date": "2026-10-27",
          "version": "0.2",
          "description": "Reframed scope in terms of study design, population, outcomes and observation window."
        },
        {
          "date": "2026-10-29",
          "version": "0.3",
          "description": "Added group sizes and within-group percentages, clarifying between-group inference and weight adjustment."
        }
      ]
    },
    "original": {
      "id": "depner-2019",
      "title": "Ad libitum Weekend Recovery Sleep Fails to Prevent Metabolic Dysregulation during a Repeating Pattern of Insufficient Sleep and Weekend Recovery Sleep",
      "authors": "Christopher M. Depner · Edward L. Melanson · Robert H. Eckel · Janet K. Snell-Bergeon · Leigh Perreault · Bryan C. Bergman · Janine A. Higgins · Molly K. Guerin · Ellen R. Stothard · Sarah J. Morton · Kenneth P. Wright",
      "journal": "Current Biology",
      "year": "2019",
      "url": "https://doi.org/10.1016/j.cub.2019.01.069",
      "doi": "10.1016/j.cub.2019.01.069",
      "pmid": "30827911"
    },
    "references": [
      {
        "id": "depner-2019",
        "title": "Ad libitum Weekend Recovery Sleep Fails to Prevent Metabolic Dysregulation during a Repeating Pattern of Insufficient Sleep and Weekend Recovery Sleep",
        "authors": "Christopher M. Depner · Edward L. Melanson · Robert H. Eckel · Janet K. Snell-Bergeon · Leigh Perreault · Bryan C. Bergman · Janine A. Higgins · Molly K. Guerin · Ellen R. Stothard · Sarah J. Morton · Kenneth P. Wright",
        "journal": "Current Biology",
        "year": "2019",
        "url": "https://doi.org/10.1016/j.cub.2019.01.069",
        "doi": "10.1016/j.cub.2019.01.069",
        "pmid": "30827911"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "What the study found",
        "paragraphs": [
          "In this short laboratory protocol, two unrestricted weekend nights followed by renewed restriction did not prevent the observed metabolic dysregulation. Whole-body insulin sensitivity fell by approximately 13% and 27% from each group's own baseline in continuous restriction and weekend recovery respectively. Those within-group percentages do not establish a significant between-group difference."
        ]
      },
      {
        "id": "limits",
        "title": "Scope & limitations",
        "paragraphs": [
          "36 young, normal-weight healthy adults, 18 women and 18 men: eight controls, 14 continuous-restriction and 14 weekend-recovery participants.",
          "The sample and duration were limited, while sleep, intake, weight and circadian timing changed together. The weight-adjusted weekend-recovery analysis had P=.054. Differences between adjusted and unadjusted results matter; the experiment does not establish that every form of catch-up sleep is without value."
        ]
      },
      {
        "id": "sample",
        "title": "Population & sample",
        "paragraphs": [
          "36 young, normal-weight healthy adults, 18 women and 18 men: eight controls, 14 continuous-restriction and 14 weekend-recovery participants."
        ]
      },
      {
        "id": "exposure",
        "title": "Exposure or intervention",
        "paragraphs": [
          "Nine-hour nightly sleep opportunity for controls, five hours for continuous restriction, or restriction followed by two unrestricted nights and renewed restriction."
        ]
      },
      {
        "id": "outcomes",
        "title": "Outcomes",
        "paragraphs": [
          "Clamp-measured insulin sensitivity, energy intake, weight and circadian measures."
        ]
      },
      {
        "id": "duration",
        "title": "Time frame",
        "paragraphs": [
          "A controlled restriction–weekend recovery–restriction cycle, without long-term free-living follow-up."
        ]
      },
      {
        "id": "funding",
        "title": "Research funding",
        "paragraphs": [
          "NIH HL109706, DK111161, TR001082, DK048520 and Sleep Research Society Foundation 011-JP-16."
        ]
      },
      {
        "id": "conflicts",
        "title": "Research conflicts of interest",
        "paragraphs": [
          "K. P. Wright disclosed NIH advisory-board membership/personal fees, Torvec scientific advice/personal fees, fees from Circadian Therapeutics and Kellogg, and outside-study support from NIH, the Office of Naval Research, PAC-12 and Somalogic. Other authors reported nothing to disclose."
        ]
      },
      {
        "id": "basis",
        "title": "Reading scope",
        "paragraphs": [
          "Full-text results, STAR Methods randomization/clamp measurements, discussion and limitations. All between-group and adjusted models have not been independently reproduced."
        ],
        "links": [
          {
            "label": "Full text in PubMed Central",
            "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12798825/"
          }
        ]
      }
    ]
  }
}