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  "work": {
    "id": "TAP-RDN-0025",
    "type": "RDN",
    "kind": "note",
    "key": "depner-2019",
    "locale": "zh",
    "path": "/zh/research/depner-2019/",
    "title": "TAP 导读: Ad libitum Weekend Recovery Sleep Fails to Prevent Metabolic Dysregulation during a Repeating Pattern of Insufficient Sleep and Weekend Recovery Sleep",
    "description": "在短期实验中，周末两夜自由补觉后再次限制睡眠，并未阻止所观察的代谢失调。相对各自基线，持续限制与周末恢复组的全身胰岛素敏感性分别下降约13%和27%；这两个组内百分比不能直接用来判定两组差异显著。",
    "rights": "© The Allostasis Project。保留所有权利。除法律允许的例外外，转载或改编需另行授权。",
    "version": "0.3",
    "updatedAt": "2026-10-29",
    "editorial": {
      "contentType": "evidence-review",
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      "reviewedVersion": null,
      "updatedAt": "2026-10-29",
      "version": "0.3",
      "author": null,
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        "ai": {
          "usage": "used",
          "system": "OpenAI Codex",
          "scope": "Assisted source comparison, evidence extraction and bilingual research-note preparation. The materials consulted and unresolved scientific issues are specified in each note.",
          "version": "0.3",
          "tasks": [
            "Source comparison and evidence extraction",
            "Bilingual research-note drafting and editorial comparison"
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      },
      "revisions": [
        {
          "date": "2026-10-27",
          "version": "0.2",
          "description": "按研究设计、人群、结局与观察窗口重写适用范围说明。"
        },
        {
          "date": "2026-10-29",
          "version": "0.3",
          "description": "补充各组样本及组内百分比，明确组间比较和体重调整的限制。"
        }
      ]
    },
    "original": {
      "id": "depner-2019",
      "title": "Ad libitum Weekend Recovery Sleep Fails to Prevent Metabolic Dysregulation during a Repeating Pattern of Insufficient Sleep and Weekend Recovery Sleep",
      "authors": "Christopher M. Depner · Edward L. Melanson · Robert H. Eckel · Janet K. Snell-Bergeon · Leigh Perreault · Bryan C. Bergman · Janine A. Higgins · Molly K. Guerin · Ellen R. Stothard · Sarah J. Morton · Kenneth P. Wright",
      "journal": "Current Biology",
      "year": "2019",
      "url": "https://doi.org/10.1016/j.cub.2019.01.069",
      "doi": "10.1016/j.cub.2019.01.069",
      "pmid": "30827911"
    },
    "references": [
      {
        "id": "depner-2019",
        "title": "Ad libitum Weekend Recovery Sleep Fails to Prevent Metabolic Dysregulation during a Repeating Pattern of Insufficient Sleep and Weekend Recovery Sleep",
        "authors": "Christopher M. Depner · Edward L. Melanson · Robert H. Eckel · Janet K. Snell-Bergeon · Leigh Perreault · Bryan C. Bergman · Janine A. Higgins · Molly K. Guerin · Ellen R. Stothard · Sarah J. Morton · Kenneth P. Wright",
        "journal": "Current Biology",
        "year": "2019",
        "url": "https://doi.org/10.1016/j.cub.2019.01.069",
        "doi": "10.1016/j.cub.2019.01.069",
        "pmid": "30827911"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "研究发现",
        "paragraphs": [
          "在短期实验中，周末两夜自由补觉后再次限制睡眠，并未阻止所观察的代谢失调。相对各自基线，持续限制与周末恢复组的全身胰岛素敏感性分别下降约13%和27%；这两个组内百分比不能直接用来判定两组差异显著。"
        ]
      },
      {
        "id": "limits",
        "title": "范围与局限",
        "paragraphs": [
          "36名年轻、正常体重的健康成年人，男女各18人；对照8人、持续限制14人、周末恢复14人。",
          "样本小、持续时间短，睡眠、进食、体重和节律同时变化。周末恢复组的体重调整分析P=.054，不能忽略调整前后的差异；实验也不能证明所有补觉方式都无价值。"
        ]
      },
      {
        "id": "sample",
        "title": "研究人群与样本",
        "paragraphs": [
          "36名年轻、正常体重的健康成年人，男女各18人；对照8人、持续限制14人、周末恢复14人。"
        ]
      },
      {
        "id": "exposure",
        "title": "暴露或干预",
        "paragraphs": [
          "对照每夜9小时睡眠机会；持续限制为5小时；恢复组在限制后获得两夜自由睡眠，再次限制。"
        ]
      },
      {
        "id": "outcomes",
        "title": "观察结局",
        "paragraphs": [
          "夹钳测定的胰岛素敏感性、能量摄入、体重及节律等结局。"
        ]
      },
      {
        "id": "duration",
        "title": "时间范围",
        "paragraphs": [
          "受控的睡眠限制—周末恢复—再限制周期；未检验长期自由生活效果。"
        ]
      },
      {
        "id": "funding",
        "title": "研究资金来源",
        "paragraphs": [
          "NIH HL109706、DK111161、TR001082、DK048520及Sleep Research Society Foundation 011-JP-16。"
        ]
      },
      {
        "id": "conflicts",
        "title": "研究利益关系",
        "paragraphs": [
          "K. P. Wright披露NIH顾问委员会及报酬、Torvec科学顾问及报酬、Circadian Therapeutics和Kellogg报酬关系，并在本研究之外获NIH、Office of Naval Research、PAC-12及Somalogic研究支持；其余作者声明无披露事项。"
        ]
      },
      {
        "id": "basis",
        "title": "导读范围",
        "paragraphs": [
          "全文结果、STAR Methods中的随机化与夹钳测量、讨论及局限；全部组间与调整模型尚未独立复算。"
        ],
        "links": [
          {
            "label": "PubMed Central全文",
            "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12798825/"
          }
        ]
      }
    ]
  }
}