{
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  "capturedAt": "2026-10-29T10:31:13.620Z",
  "sha256": "cb7fda10d4cf63a9da194dfc0f172f30405d4905d89a152b94595ecf325756b6",
  "work": {
    "id": "TAP-RDN-0026",
    "type": "RDN",
    "kind": "note",
    "key": "pejovic-2013",
    "locale": "en",
    "path": "/research/pejovic-2013/",
    "title": "TAP reading note: Effects of recovery sleep after one work week of mild sleep restriction on interleukin-6 and cortisol secretion and daytime sleepiness and performance",
    "description": "Recovery differed across outcomes after mild sleep restriction. After two extended nights, IL-6 was not significantly different from baseline and sleepiness/fatigue improved, but sustained-attention performance did not recover. Twenty-four-hour cortisol had not significantly increased during restriction, so its subsequent fall is not evidence that all stress measures returned together.",
    "rights": "© The Allostasis Project. All rights reserved. Reproduction or adaptation requires separate permission, subject to applicable legal exceptions.",
    "version": "0.3",
    "updatedAt": "2026-10-29",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-10-29",
      "version": "0.3",
      "author": null,
      "reviewer": null,
      "workflow": {
        "ai": {
          "usage": "used",
          "system": "OpenAI Codex",
          "scope": "Assisted source comparison, evidence extraction and bilingual research-note preparation. The materials consulted and unresolved scientific issues are specified in each note.",
          "version": "0.3",
          "tasks": [
            "Source comparison and evidence extraction",
            "Bilingual research-note drafting and editorial comparison"
          ]
        }
      },
      "revisions": [
        {
          "date": "2026-10-27",
          "version": "0.2",
          "description": "Reframed scope in terms of study design, population, outcomes and observation window."
        },
        {
          "date": "2026-10-29",
          "version": "0.3",
          "description": "Added the fixed-sequence design, IL-6 comparison and absence of a significant restriction-period cortisol increase."
        }
      ]
    },
    "original": {
      "id": "pejovic-2013",
      "title": "Effects of recovery sleep after one work week of mild sleep restriction on interleukin-6 and cortisol secretion and daytime sleepiness and performance",
      "authors": "Slobodanka Pejovic · Maria Basta · Alexandros N. Vgontzas · Ilia Kritikou · Michele L. Shaffer · Marina Tsaoussoglou · David Stiffler · Zacharias Stefanakis · Edward O. Bixler · George P. Chrousos",
      "journal": "American Journal of Physiology-Endocrinology and Metabolism",
      "year": "2013",
      "url": "https://doi.org/10.1152/ajpendo.00301.2013",
      "doi": "10.1152/ajpendo.00301.2013",
      "pmid": "23941878"
    },
    "references": [
      {
        "id": "pejovic-2013",
        "title": "Effects of recovery sleep after one work week of mild sleep restriction on interleukin-6 and cortisol secretion and daytime sleepiness and performance",
        "authors": "Slobodanka Pejovic · Maria Basta · Alexandros N. Vgontzas · Ilia Kritikou · Michele L. Shaffer · Marina Tsaoussoglou · David Stiffler · Zacharias Stefanakis · Edward O. Bixler · George P. Chrousos",
        "journal": "American Journal of Physiology-Endocrinology and Metabolism",
        "year": "2013",
        "url": "https://doi.org/10.1152/ajpendo.00301.2013",
        "doi": "10.1152/ajpendo.00301.2013",
        "pmid": "23941878"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "What the study found",
        "paragraphs": [
          "Recovery differed across outcomes after mild sleep restriction. After two extended nights, IL-6 was not significantly different from baseline and sleepiness/fatigue improved, but sustained-attention performance did not recover. Twenty-four-hour cortisol had not significantly increased during restriction, so its subsequent fall is not evidence that all stress measures returned together."
        ]
      },
      {
        "id": "limits",
        "title": "Scope & limitations",
        "paragraphs": [
          "30 healthy adults, 16 men and 14 women, in a fixed-sequence within-person experiment.",
          "Without an external control, sequence, practice, earlier awakening and daytime activity may confound results. A nonsignificant baseline difference is not an equivalence test. Findings apply to the measured outcomes and recovery window."
        ]
      },
      {
        "id": "sample",
        "title": "Population & sample",
        "paragraphs": [
          "30 healthy adults, 16 men and 14 women, in a fixed-sequence within-person experiment."
        ]
      },
      {
        "id": "exposure",
        "title": "Exposure or intervention",
        "paragraphs": [
          "Four eight-hour, six six-hour and three ten-hour time-in-bed nights; key measurements after five restricted and two recovery nights."
        ]
      },
      {
        "id": "outcomes",
        "title": "Outcomes",
        "paragraphs": [
          "IL-6, 24-hour cortisol, sleepiness, fatigue and vigilance. Post-recovery IL-6 difference from baseline was .02±.34 pg/mL, P=.94."
        ]
      },
      {
        "id": "duration",
        "title": "Time frame",
        "paragraphs": [
          "13-night protocol, focusing on restriction and the state after two recovery nights."
        ]
      },
      {
        "id": "funding",
        "title": "Research funding",
        "paragraphs": [
          "Not yet verified against the full text."
        ]
      },
      {
        "id": "conflicts",
        "title": "Research conflicts of interest",
        "paragraphs": [
          "Not yet verified against the full text."
        ]
      },
      {
        "id": "basis",
        "title": "Reading scope",
        "paragraphs": [
          "PMC web full-text protocol, blood sampling, results and discussion. Independent controls, circadian alignment and longer recovery require other studies."
        ],
        "links": [
          {
            "label": "Full text in PubMed Central",
            "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC3798707/"
          }
        ]
      }
    ]
  }
}