{
  "schemaVersion": 1,
  "capturedAt": "2026-09-14T11:37:40.856Z",
  "sha256": "3993e90d91520487d0f3c901b9ca97011f484c7b3d5303c0be89a888f50470c8",
  "work": {
    "id": "TAP-RDN-0031",
    "kind": "note",
    "key": "li-2024",
    "locale": "en",
    "path": "/research/li-2024/",
    "title": "TAP reading note: Impact of baseline and longitudinal allostatic load changes on incident cardiovascular disease and all-cause mortality: A 7-year population-based cohort study in China",
    "description": "In CHARLS participants aged 45 and older, higher baseline allostatic load and increases over time were associated with subsequent cardiovascular disease and all-cause mortality.",
    "rights": "© The Allostasis Project. All rights reserved. Reproduction or adaptation requires separate permission, subject to applicable legal exceptions.",
    "version": "0.1",
    "updatedAt": "2026-09-14",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-09-14",
      "version": "0.1",
      "author": null,
      "reviewer": null,
      "revisions": []
    },
    "original": {
      "id": "li-2024",
      "title": "Impact of baseline and longitudinal allostatic load changes on incident cardiovascular disease and all-cause mortality: A 7-year population-based cohort study in China",
      "authors": "Yachao Li · Chu Chen · Ying Wen · Xiuli Wang · Ziqian Zeng · Hongying Shi · Xiaofang Chen · Ruichan Sun · Qingping Xue",
      "journal": "Journal of Affective Disorders",
      "year": "2024",
      "url": "https://doi.org/10.1016/j.jad.2024.03.124",
      "doi": "10.1016/j.jad.2024.03.124",
      "pmid": "38548202"
    },
    "references": [
      {
        "id": "li-2024",
        "title": "Impact of baseline and longitudinal allostatic load changes on incident cardiovascular disease and all-cause mortality: A 7-year population-based cohort study in China",
        "authors": "Yachao Li · Chu Chen · Ying Wen · Xiuli Wang · Ziqian Zeng · Hongying Shi · Xiaofang Chen · Ruichan Sun · Qingping Xue",
        "journal": "Journal of Affective Disorders",
        "year": "2024",
        "url": "https://doi.org/10.1016/j.jad.2024.03.124",
        "doi": "10.1016/j.jad.2024.03.124",
        "pmid": "38548202"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "What the study found",
        "paragraphs": [
          "In CHARLS participants aged 45 and older, higher baseline allostatic load and increases over time were associated with subsequent cardiovascular disease and all-cause mortality."
        ]
      },
      {
        "id": "limits",
        "title": "Scope & limitations",
        "paragraphs": [
          "Analysis of the China Health and Retirement Longitudinal Study; outcome-specific sample counts are not stated in the abstract used for this note.",
          "Observational associations do not prove that lowering an AL score changes risk. Cardiovascular disease was based on self-reported physician diagnosis, and findings do not automatically generalize to younger adults."
        ]
      },
      {
        "id": "sample",
        "title": "Population & sample",
        "paragraphs": [
          "Analysis of the China Health and Retirement Longitudinal Study; outcome-specific sample counts are not stated in the abstract used for this note."
        ]
      },
      {
        "id": "exposure",
        "title": "Exposure or intervention",
        "paragraphs": [
          "Baseline allostatic load and change in AL across four years."
        ]
      },
      {
        "id": "outcomes",
        "title": "Outcomes",
        "paragraphs": [
          "Incident cardiovascular disease and all-cause mortality assessed separately using adjusted survival models."
        ]
      },
      {
        "id": "duration",
        "title": "Time frame",
        "paragraphs": [
          "A seven-year cohort analysis, with AL change assessed over a four-year interval."
        ]
      },
      {
        "id": "funding",
        "title": "Research funding",
        "paragraphs": [
          "Not yet checked against the full publication."
        ]
      },
      {
        "id": "conflicts",
        "title": "Research conflicts of interest",
        "paragraphs": [
          "Not yet checked against the full publication."
        ]
      },
      {
        "id": "basis",
        "title": "Reading scope",
        "paragraphs": [
          "Based on the original publication’s abstract and bibliographic record. This is a selected reading note, not a systematic appraisal."
        ]
      }
    ],
    "type": "RDN"
  }
}