{
  "schemaVersion": 1,
  "capturedAt": "2026-10-27T11:18:42.872Z",
  "sha256": "096f48cef342c077c09bb6f91f056f07e6361574582b5c5657c0f4810adeec63",
  "work": {
    "id": "TAP-RDN-0031",
    "type": "RDN",
    "kind": "note",
    "key": "li-2024",
    "locale": "en",
    "path": "/research/li-2024/",
    "title": "TAP reading note: Impact of baseline and longitudinal allostatic load changes on incident cardiovascular disease and all-cause mortality: A 7-year population-based cohort study in China",
    "description": "In CHARLS participants aged 45 and older, higher baseline allostatic load and increases over time were associated with subsequent cardiovascular disease and all-cause mortality.",
    "rights": "© The Allostasis Project. All rights reserved. Reproduction or adaptation requires separate permission, subject to applicable legal exceptions.",
    "version": "0.2",
    "updatedAt": "2026-10-27",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-10-27",
      "version": "0.2",
      "author": null,
      "reviewer": null,
      "workflow": {
        "ai": {
          "usage": "used",
          "system": "TAP Research Agent / OpenAI Codex",
          "scope": "Bilingual editorial revision and consolidation of scope statements based on the published text.",
          "version": "0.2",
          "tasks": [
            "Bilingual editing",
            "Scope and citation-position comparison"
          ]
        }
      },
      "revisions": [
        {
          "date": "2026-10-27",
          "version": "0.2",
          "description": "Reframed scope in terms of study design, population, outcomes and observation window."
        }
      ]
    },
    "original": {
      "id": "li-2024",
      "title": "Impact of baseline and longitudinal allostatic load changes on incident cardiovascular disease and all-cause mortality: A 7-year population-based cohort study in China",
      "authors": "Yachao Li · Chu Chen · Ying Wen · Xiuli Wang · Ziqian Zeng · Hongying Shi · Xiaofang Chen · Ruichan Sun · Qingping Xue",
      "journal": "Journal of Affective Disorders",
      "year": "2024",
      "url": "https://doi.org/10.1016/j.jad.2024.03.124",
      "doi": "10.1016/j.jad.2024.03.124",
      "pmid": "38548202"
    },
    "references": [
      {
        "id": "li-2024",
        "title": "Impact of baseline and longitudinal allostatic load changes on incident cardiovascular disease and all-cause mortality: A 7-year population-based cohort study in China",
        "authors": "Yachao Li · Chu Chen · Ying Wen · Xiuli Wang · Ziqian Zeng · Hongying Shi · Xiaofang Chen · Ruichan Sun · Qingping Xue",
        "journal": "Journal of Affective Disorders",
        "year": "2024",
        "url": "https://doi.org/10.1016/j.jad.2024.03.124",
        "doi": "10.1016/j.jad.2024.03.124",
        "pmid": "38548202"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "What the study found",
        "paragraphs": [
          "In CHARLS participants aged 45 and older, higher baseline allostatic load and increases over time were associated with subsequent cardiovascular disease and all-cause mortality."
        ]
      },
      {
        "id": "limits",
        "title": "Scope & limitations",
        "paragraphs": [
          "Analysis of the China Health and Retirement Longitudinal Study; outcome-specific sample counts are not stated in the abstract used for this note.",
          "The observational design limits causal interpretation, and cardiovascular disease was based on self-reported physician diagnosis. Findings should be interpreted within the study’s age range and follow-up conditions."
        ]
      },
      {
        "id": "sample",
        "title": "Population & sample",
        "paragraphs": [
          "Analysis of the China Health and Retirement Longitudinal Study; outcome-specific sample counts are not stated in the abstract used for this note."
        ]
      },
      {
        "id": "exposure",
        "title": "Exposure or intervention",
        "paragraphs": [
          "Baseline allostatic load and change in AL across four years."
        ]
      },
      {
        "id": "outcomes",
        "title": "Outcomes",
        "paragraphs": [
          "Incident cardiovascular disease and all-cause mortality assessed separately using adjusted survival models."
        ]
      },
      {
        "id": "duration",
        "title": "Time frame",
        "paragraphs": [
          "A seven-year cohort analysis, with AL change assessed over a four-year interval."
        ]
      },
      {
        "id": "funding",
        "title": "Research funding",
        "paragraphs": [
          "Not yet checked against the full publication."
        ]
      },
      {
        "id": "conflicts",
        "title": "Research conflicts of interest",
        "paragraphs": [
          "Not yet checked against the full publication."
        ]
      },
      {
        "id": "basis",
        "title": "Reading scope",
        "paragraphs": [
          "Based on the original publication’s abstract and bibliographic record. This is a selected reading note, not a systematic appraisal."
        ]
      }
    ]
  }
}