{
  "schemaVersion": 1,
  "capturedAt": "2026-09-14T11:37:40.865Z",
  "sha256": "d15934f016d65aef80a2a895460b62965f50118a67d00b592c85eb2872939186",
  "work": {
    "id": "TAP-RDN-0031",
    "kind": "note",
    "key": "li-2024",
    "locale": "zh",
    "path": "/zh/research/li-2024/",
    "title": "TAP 导读: Impact of baseline and longitudinal allostatic load changes on incident cardiovascular disease and all-cause mortality: A 7-year population-based cohort study in China",
    "description": "在 CHARLS 中 45 岁及以上参与者中，较高的基线适应负荷及其随时间增加，与后续心血管疾病和全因死亡相关。",
    "rights": "© The Allostasis Project。保留所有权利。除法律允许的例外外，转载或改编需另行授权。",
    "version": "0.1",
    "updatedAt": "2026-09-14",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-09-14",
      "version": "0.1",
      "author": null,
      "reviewer": null,
      "revisions": []
    },
    "original": {
      "id": "li-2024",
      "title": "Impact of baseline and longitudinal allostatic load changes on incident cardiovascular disease and all-cause mortality: A 7-year population-based cohort study in China",
      "authors": "Yachao Li · Chu Chen · Ying Wen · Xiuli Wang · Ziqian Zeng · Hongying Shi · Xiaofang Chen · Ruichan Sun · Qingping Xue",
      "journal": "Journal of Affective Disorders",
      "year": "2024",
      "url": "https://doi.org/10.1016/j.jad.2024.03.124",
      "doi": "10.1016/j.jad.2024.03.124",
      "pmid": "38548202"
    },
    "references": [
      {
        "id": "li-2024",
        "title": "Impact of baseline and longitudinal allostatic load changes on incident cardiovascular disease and all-cause mortality: A 7-year population-based cohort study in China",
        "authors": "Yachao Li · Chu Chen · Ying Wen · Xiuli Wang · Ziqian Zeng · Hongying Shi · Xiaofang Chen · Ruichan Sun · Qingping Xue",
        "journal": "Journal of Affective Disorders",
        "year": "2024",
        "url": "https://doi.org/10.1016/j.jad.2024.03.124",
        "doi": "10.1016/j.jad.2024.03.124",
        "pmid": "38548202"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "研究发现",
        "paragraphs": [
          "在 CHARLS 中 45 岁及以上参与者中，较高的基线适应负荷及其随时间增加，与后续心血管疾病和全因死亡相关。"
        ]
      },
      {
        "id": "limits",
        "title": "范围与局限",
        "paragraphs": [
          "中国健康与养老追踪调查分析；本导读使用的摘要未列出各结局的具体分析人数。",
          "观察性关联不能证明降低 AL 分数就能改变风险。心血管疾病依据参与者自报的医生诊断，结果也不能自动外推到年轻人。"
        ]
      },
      {
        "id": "sample",
        "title": "研究人群与样本",
        "paragraphs": [
          "中国健康与养老追踪调查分析；本导读使用的摘要未列出各结局的具体分析人数。"
        ]
      },
      {
        "id": "exposure",
        "title": "暴露或干预",
        "paragraphs": [
          "基线适应负荷，以及四年内 AL 的变化。"
        ]
      },
      {
        "id": "outcomes",
        "title": "观察结局",
        "paragraphs": [
          "以调整后的生存模型分别考察新发心血管疾病和全因死亡。"
        ]
      },
      {
        "id": "duration",
        "title": "时间范围",
        "paragraphs": [
          "七年队列分析，其中 AL 变化使用四年间隔进行评估。"
        ]
      },
      {
        "id": "funding",
        "title": "研究资金来源",
        "paragraphs": [
          "尚未根据完整论文核查。"
        ]
      },
      {
        "id": "conflicts",
        "title": "研究利益关系",
        "paragraphs": [
          "尚未根据完整论文核查。"
        ]
      },
      {
        "id": "basis",
        "title": "导读范围",
        "paragraphs": [
          "依据原论文摘要与书目记录撰写的精选导读，未进行系统证据评价。"
        ]
      }
    ],
    "type": "RDN"
  }
}