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  "capturedAt": "2026-09-16T13:27:22.834Z",
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    "kind": "note",
    "type": "RDN",
    "key": "romero-2009",
    "id": "TAP-RDN-0032",
    "locale": "en",
    "path": "/research/romero-2009/",
    "title": "TAP reading note: The Reactive Scope Model — A new model integrating homeostasis, allostasis, and stress",
    "description": "Proposes four ranges of physiological mediators: predictable regulation, responses to unexpected demands, overload and failure. The authors use changing boundaries to describe how history and context may alter an individual’s reactive scope.",
    "rights": "© The Allostasis Project. All rights reserved. Reproduction or adaptation requires separate permission, subject to applicable legal exceptions.",
    "version": "0.1",
    "updatedAt": "2026-09-16",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-09-16",
      "version": "0.1",
      "author": null,
      "reviewer": null,
      "workflow": {
        "ai": {
          "usage": "used",
          "system": "OpenAI Codex (GPT-6)",
          "scope": "Conceptual synthesis and source-linked educational preparation; not completed human scientific or methodological review.",
          "version": "0.1",
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      "revisions": []
    },
    "original": {
      "id": "romero-2009",
      "title": "The Reactive Scope Model — A new model integrating homeostasis, allostasis, and stress",
      "authors": "L. Michael Romero · Molly J. Dickens · Nicole E. Cyr",
      "journal": "Hormones and Behavior",
      "year": "2009",
      "url": "https://doi.org/10.1016/j.yhbeh.2008.12.009",
      "doi": "10.1016/j.yhbeh.2008.12.009",
      "pmid": "19470371"
    },
    "references": [
      {
        "id": "romero-2009",
        "title": "The Reactive Scope Model — A new model integrating homeostasis, allostasis, and stress",
        "authors": "L. Michael Romero · Molly J. Dickens · Nicole E. Cyr",
        "journal": "Hormones and Behavior",
        "year": "2009",
        "url": "https://doi.org/10.1016/j.yhbeh.2008.12.009",
        "doi": "10.1016/j.yhbeh.2008.12.009",
        "pmid": "19470371"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "What the study found",
        "paragraphs": [
          "Proposes four ranges of physiological mediators: predictable regulation, responses to unexpected demands, overload and failure. The authors use changing boundaries to describe how history and context may alter an individual’s reactive scope."
        ]
      },
      {
        "id": "limits",
        "title": "Scope & limitations",
        "paragraphs": [
          "Conceptual framework across comparative physiology; no single trial sample.",
          "The proposed ranges are not universal human cutoffs or a validated whole-body reserve scale."
        ]
      },
      {
        "id": "sample",
        "title": "Population & sample",
        "paragraphs": [
          "No new cohort or intervention trial is reported in the abstract."
        ]
      },
      {
        "id": "exposure",
        "title": "Exposure or intervention",
        "paragraphs": [
          "Predictable and unpredictable demands; mediator levels and changing response ranges."
        ]
      },
      {
        "id": "outcomes",
        "title": "Outcomes",
        "paragraphs": [
          "A graphical model of regulation and overload, not a clinical effect estimate."
        ]
      },
      {
        "id": "duration",
        "title": "Time frame",
        "paragraphs": [
          "Multiple timescales; no single follow-up period."
        ]
      },
      {
        "id": "funding",
        "title": "Research funding",
        "paragraphs": [
          "The bibliographic abstract does not report funding."
        ]
      },
      {
        "id": "conflicts",
        "title": "Research conflicts of interest",
        "paragraphs": [
          "The bibliographic abstract does not report a conflict-of-interest declaration."
        ]
      },
      {
        "id": "basis",
        "title": "Reading scope",
        "paragraphs": [
          "PubMed/Europe PMC abstract and bibliographic metadata. This reading note describes the proposed model; it does not assess empirical validation across species."
        ]
      }
    ]
  }
}