{
  "schemaVersion": 1,
  "capturedAt": "2026-09-20T06:32:55.672Z",
  "sha256": "9f9b9386edd68c4cbe6f524844a730798d61368f58323044b31cd3a20b34a462",
  "work": {
    "type": "RDN",
    "kind": "note",
    "key": "beese-2025",
    "id": "TAP-RDN-0035",
    "locale": "en",
    "path": "/research/beese-2025/",
    "title": "TAP reading note: Allostatic (over)Load Measurement: Workflow and repository",
    "description": "A workflow and repository make the construction of a five-marker allostatic-load index inspectable across secondary datasets. The preprint describes the workflow; TAP separately tested sensitivity to reference populations and scoring rules in NHANES 2015–2016.",
    "rights": "© The Allostasis Project. All rights reserved. Reproduction or adaptation requires separate permission, subject to applicable legal exceptions.",
    "version": "1.0",
    "updatedAt": "2026-09-20",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-09-20",
      "version": "1.0",
      "byline": "team",
      "author": null,
      "reviewer": null,
      "workflow": {
        "ai": {
          "usage": "used",
          "system": "TAP Research Agent / Codex",
          "scope": "Computational checks are reported separately from human scientific or methods review.",
          "version": "1.0",
          "tasks": [
            "Source inspection",
            "Independent analysis implementation",
            "Numerical cross-checking",
            "Writing and translation"
          ]
        }
      },
      "revisions": []
    },
    "original": {
      "id": "beese-2025",
      "title": "Allostatic (over)Load Measurement: Workflow and repository",
      "authors": "Shawna Beese · J. Cross · D. Rice · T. L. DeJong",
      "journal": "medRxiv (preprint)",
      "year": "2025",
      "url": "https://doi.org/10.1101/2025.07.31.25332519",
      "doi": "10.1101/2025.07.31.25332519"
    },
    "references": [
      {
        "id": "beese-2025",
        "title": "Allostatic (over)Load Measurement: Workflow and repository",
        "authors": "Shawna Beese · J. Cross · D. Rice · T. L. DeJong",
        "journal": "medRxiv (preprint)",
        "year": "2025",
        "url": "https://doi.org/10.1101/2025.07.31.25332519",
        "doi": "10.1101/2025.07.31.25332519"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "What the study found",
        "paragraphs": [
          "A workflow and repository make the construction of a five-marker allostatic-load index inspectable across secondary datasets. The preprint describes the workflow; TAP separately tested sensitivity to reference populations and scoring rules in NHANES 2015–2016."
        ]
      },
      {
        "id": "limits",
        "title": "Scope & limitations",
        "paragraphs": [
          "Secondary-data workflow covering All of Us, HRS and NHANES; these are separate source populations, not one pooled validation cohort.",
          "Preprint, not a validated personal stress or resilience instrument. A computed index does not establish universal diagnostic thresholds, daily recovery sensitivity or predictive performance. The repository evolved after the 2025 preprint, so code and paper versions must be identified separately."
        ]
      },
      {
        "id": "sample",
        "title": "Population & sample",
        "paragraphs": [
          "The source workflow covers three data resources. TAP’s accompanying methods case evaluates 3,152 complete-panel adults aged 40+ in NHANES 2015–2016; this is TAP’s sample, not the sample size of the source paper."
        ]
      },
      {
        "id": "exposure",
        "title": "Exposure or intervention",
        "paragraphs": [
          "Five markers: CRP, HbA1c, HDL cholesterol, heart rate or survey pulse, and waist-to-height ratio. Implementation includes data assembly, threshold selection and summing risk flags."
        ]
      },
      {
        "id": "outcomes",
        "title": "Outcomes",
        "paragraphs": [
          "A calculated allostatic-load index. The workflow’s reproducibility is distinct from validation against disease, mortality or within-person recovery outcomes."
        ]
      },
      {
        "id": "duration",
        "title": "Time frame",
        "paragraphs": [
          "Preprint version 1: 1 August 2025. Code inspected: commit 2bbb624dd01cec5c54b778d3cd2df4ada582c989 (2026 update). TAP’s own analysis uses one NHANES cycle, 2015–2016."
        ]
      },
      {
        "id": "funding",
        "title": "Research funding",
        "paragraphs": [
          "Source-paper funding was not independently extracted for this reading note; consult the original preprint’s statement."
        ]
      },
      {
        "id": "conflicts",
        "title": "Research conflicts of interest",
        "paragraphs": [
          "Source-author conflicts were not independently audited by TAP. Citation does not indicate endorsement of TAP or Resilio."
        ]
      },
      {
        "id": "basis",
        "title": "Reading scope",
        "paragraphs": [
          "Preprint abstract and previously inspected workflow text; fixed repository source; source metadata reconfirmed through medRxiv on 20 September 2026 (no journal publication link returned). TAP independently reconstructed the NHANES cycle logic and executed native R checks; it did not run the complete source notebooks or reproduce All of Us/HRS. See the linked TAP methods case for new results."
        ]
      }
    ]
  }
}