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    "key": "wopereis-2017",
    "id": "TAP-RDN-0036",
    "locale": "en",
    "path": "/research/wopereis-2017/",
    "title": "TAP reading note: Multi-parameter comparison of a standardized mixed meal tolerance test in healthy and type 2 diabetic subjects: the PhenFlex challenge",
    "description": "Meal-challenge responses distinguished metabolic groups beyond fasting measurements.",
    "rights": "© The Allostasis Project. All rights reserved. Reproduction or adaptation requires separate permission, subject to applicable legal exceptions.",
    "version": "1.0",
    "updatedAt": "2026-10-15",
    "editorial": {
      "contentType": "evidence-review",
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      "updatedAt": "2026-10-15",
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    "original": {
      "id": "wopereis-2017",
      "title": "Multi-parameter comparison of a standardized mixed meal tolerance test in healthy and type 2 diabetic subjects: the PhenFlex challenge",
      "authors": "Suzan Wopereis et al.",
      "journal": "Genes & Nutrition",
      "year": "2017",
      "url": "https://doi.org/10.1186/s12263-017-0570-6",
      "doi": "10.1186/s12263-017-0570-6"
    },
    "references": [
      {
        "id": "wopereis-2017",
        "title": "Multi-parameter comparison of a standardized mixed meal tolerance test in healthy and type 2 diabetic subjects: the PhenFlex challenge",
        "authors": "Suzan Wopereis et al.",
        "journal": "Genes & Nutrition",
        "year": "2017",
        "url": "https://doi.org/10.1186/s12263-017-0570-6",
        "doi": "10.1186/s12263-017-0570-6"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "What the study found",
        "paragraphs": [
          "Meal-challenge responses distinguished metabolic groups beyond fasting measurements."
        ]
      },
      {
        "id": "limits",
        "title": "Scope & limitations",
        "paragraphs": [
          "40 men: 20 healthy and 20 with type 2 diabetes.",
          "An exploratory group comparison, not evidence that a supplement improves everyday resilience."
        ]
      },
      {
        "id": "sample",
        "title": "Population & sample",
        "paragraphs": [
          "40 men: 20 healthy and 20 with type 2 diabetes."
        ]
      },
      {
        "id": "exposure",
        "title": "Exposure or intervention",
        "paragraphs": [
          "Mixed-meal and glucose challenges in randomized order."
        ]
      },
      {
        "id": "outcomes",
        "title": "Outcomes",
        "paragraphs": [
          "Repeated metabolic markers."
        ]
      },
      {
        "id": "duration",
        "title": "Time frame",
        "paragraphs": [
          "Eight hours per challenge."
        ]
      },
      {
        "id": "funding",
        "title": "Research funding",
        "paragraphs": [
          "TNO, industry co-funders and EU NutriTech supported the study."
        ]
      },
      {
        "id": "conflicts",
        "title": "Research conflicts of interest",
        "paragraphs": [
          "Authors declared no competing interests."
        ]
      },
      {
        "id": "basis",
        "title": "Reading scope",
        "paragraphs": [
          "Publisher abstract, methods and declarations."
        ]
      }
    ]
  }
}