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  "capturedAt": "2026-10-27T11:18:42.893Z",
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  "work": {
    "kind": "note",
    "type": "RDN",
    "key": "wopereis-2017",
    "id": "TAP-RDN-0036",
    "locale": "zh",
    "path": "/zh/research/wopereis-2017/",
    "title": "TAP 导读: Multi-parameter comparison of a standardized mixed meal tolerance test in healthy and type 2 diabetic subjects: the PhenFlex challenge",
    "description": "餐后响应揭示了空腹测量之外的代谢组间差异。",
    "rights": "© The Allostasis Project。保留所有权利。除法律允许的例外外，转载或改编需另行授权。",
    "version": "1.1",
    "updatedAt": "2026-10-27",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-10-27",
      "version": "1.1",
      "byline": "team",
      "author": null,
      "reviewer": null,
      "workflow": {
        "ai": {
          "usage": "used",
          "system": "TAP Research Agent / OpenAI Codex",
          "scope": "基于已发布正文的中英文表达修订与范围说明整理。",
          "version": "1.1",
          "tasks": [
            "中英文编辑",
            "范围说明与引用位置对照"
          ]
        }
      },
      "revisions": [
        {
          "date": "2026-10-27",
          "version": "1.1",
          "description": "按研究设计、人群、结局与观察窗口重写适用范围说明。"
        }
      ]
    },
    "original": {
      "id": "wopereis-2017",
      "title": "Multi-parameter comparison of a standardized mixed meal tolerance test in healthy and type 2 diabetic subjects: the PhenFlex challenge",
      "authors": "Suzan Wopereis et al.",
      "journal": "Genes & Nutrition",
      "year": "2017",
      "url": "https://doi.org/10.1186/s12263-017-0570-6",
      "doi": "10.1186/s12263-017-0570-6"
    },
    "references": [
      {
        "id": "wopereis-2017",
        "title": "Multi-parameter comparison of a standardized mixed meal tolerance test in healthy and type 2 diabetic subjects: the PhenFlex challenge",
        "authors": "Suzan Wopereis et al.",
        "journal": "Genes & Nutrition",
        "year": "2017",
        "url": "https://doi.org/10.1186/s12263-017-0570-6",
        "doi": "10.1186/s12263-017-0570-6"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "研究发现",
        "paragraphs": [
          "餐后响应揭示了空腹测量之外的代谢组间差异。"
        ]
      },
      {
        "id": "limits",
        "title": "范围与局限",
        "paragraphs": [
          "40名男性：健康组与2型糖尿病组各20名。",
          "这是一项探索性的组间代谢响应比较。它提供挑战测试的研究方法，干预效果则需要适当对照的干预研究。"
        ]
      },
      {
        "id": "sample",
        "title": "研究人群与样本",
        "paragraphs": [
          "40名男性：健康组与2型糖尿病组各20名。"
        ]
      },
      {
        "id": "exposure",
        "title": "暴露或干预",
        "paragraphs": [
          "以随机顺序接受混合餐与葡萄糖挑战。"
        ]
      },
      {
        "id": "outcomes",
        "title": "观察结局",
        "paragraphs": [
          "多时间点代谢指标。"
        ]
      },
      {
        "id": "duration",
        "title": "时间范围",
        "paragraphs": [
          "每次挑战观察8小时。"
        ]
      },
      {
        "id": "funding",
        "title": "研究资金来源",
        "paragraphs": [
          "TNO、行业共同资助方及欧盟NutriTech支持。"
        ]
      },
      {
        "id": "conflicts",
        "title": "研究利益关系",
        "paragraphs": [
          "作者声明无利益冲突。"
        ]
      },
      {
        "id": "basis",
        "title": "导读范围",
        "paragraphs": [
          "出版社摘要、方法和声明。"
        ]
      }
    ]
  }
}