{
  "schemaVersion": 1,
  "capturedAt": "2026-10-29T10:31:13.637Z",
  "sha256": "2e46fb30fdb5e45300e00995e65a3df1523df131fda6eca50a3d417dae6fa181",
  "work": {
    "type": "RDN",
    "kind": "note",
    "key": "beese-2026",
    "id": "TAP-RDN-0048",
    "locale": "en",
    "path": "/research/beese-2026/",
    "title": "TAP reading note: Allostatic (over) load measurement: Workflow and repository",
    "description": "The paper makes allostatic-load data cleaning, marker selection and scoring more reproducible, applying a shared workflow separately to All of Us, HRS and NHANES. Its main contribution is traceable measurement choices rather than validation of a new clinical score.",
    "rights": "© The Allostasis Project. All rights reserved. Reproduction or adaptation requires separate permission, subject to applicable legal exceptions.",
    "version": "1.0",
    "updatedAt": "2026-10-29",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-10-29",
      "version": "1.0",
      "byline": "team",
      "author": null,
      "reviewer": null,
      "workflow": {
        "ai": {
          "usage": "used",
          "system": "OpenAI Codex",
          "scope": "Assisted source comparison, evidence extraction and bilingual research-note preparation. The materials consulted and unresolved scientific issues are specified in each note.",
          "version": "1.0",
          "tasks": [
            "Source comparison and evidence extraction",
            "Bilingual research-note drafting and editorial comparison"
          ]
        }
      },
      "revisions": [
        {
          "date": "2026-10-29",
          "version": "1.0",
          "description": "Added the cross-database workflow and its unresolved CRP-threshold discrepancy."
        }
      ]
    },
    "original": {
      "id": "beese-2026",
      "title": "Allostatic (over) load measurement: Workflow and repository",
      "authors": "Beese S · Cross J · Rice D · DeJong TL",
      "journal": "PLOS One",
      "year": "2026",
      "url": "https://doi.org/10.1371/journal.pone.0360639",
      "doi": "10.1371/journal.pone.0360639",
      "pmid": "42905797"
    },
    "references": [
      {
        "id": "beese-2026",
        "title": "Allostatic (over) load measurement: Workflow and repository",
        "authors": "Beese S · Cross J · Rice D · DeJong TL",
        "journal": "PLOS One",
        "year": "2026",
        "url": "https://doi.org/10.1371/journal.pone.0360639",
        "doi": "10.1371/journal.pone.0360639",
        "pmid": "42905797"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "What the study found",
        "paragraphs": [
          "The paper makes allostatic-load data cleaning, marker selection and scoring more reproducible, applying a shared workflow separately to All of Us, HRS and NHANES. Its main contribution is traceable measurement choices rather than validation of a new clinical score."
        ]
      },
      {
        "id": "limits",
        "title": "Scope & limitations",
        "paragraphs": [
          "Three databases analysed separately; the All of Us workflow included 37,866 people. Individual records were not pooled across databases.",
          "Within-sample quantiles depend on population and measurement. Table 9 lists CRP cutoffs of 14.20, 4.29 and 4.14, with a coefficient of variation of 0.7638; their relationship to the text's heterogeneity summary needs clarification of units and scope. This unresolved discrepancy is not a formal correction and does not establish interchangeable thresholds."
        ]
      },
      {
        "id": "sample",
        "title": "Population & sample",
        "paragraphs": [
          "Three databases analysed separately; the All of Us workflow included 37,866 people. Individual records were not pooled across databases."
        ]
      },
      {
        "id": "exposure",
        "title": "Exposure or intervention",
        "paragraphs": [
          "Cleaning and quantile-based risk scoring of five markers, using historical NHANES extremes to inform plausibility ranges and discussing clinical-cutoff sensitivity analyses."
        ]
      },
      {
        "id": "outcomes",
        "title": "Outcomes",
        "paragraphs": [
          "Workflow, retained samples and biomarker thresholds; no single clinical-validation endpoint."
        ]
      },
      {
        "id": "duration",
        "title": "Time frame",
        "paragraphs": [
          "Observation periods differ by database; the study addresses measurement rather than recovery after an intervention."
        ]
      },
      {
        "id": "funding",
        "title": "Research funding",
        "paragraphs": [
          "The authors report no specific funding for this work."
        ]
      },
      {
        "id": "conflicts",
        "title": "Research conflicts of interest",
        "paragraphs": [
          "The authors declare no competing interests."
        ]
      },
      {
        "id": "basis",
        "title": "Reading scope",
        "paragraphs": [
          "Full-text methods, cleaning/scoring, Tables 3 and 9 and limitations. Code, complex-survey weighting and all supplements have not been independently checked."
        ],
        "links": [
          {
            "label": "Full text in PubMed Central",
            "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13686455/"
          }
        ]
      }
    ]
  }
}