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  "work": {
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    "kind": "note",
    "key": "beese-2026",
    "id": "TAP-RDN-0048",
    "locale": "zh",
    "path": "/zh/research/beese-2026/",
    "title": "TAP 导读: Allostatic (over) load measurement: Workflow and repository",
    "description": "论文把适应负荷的资料清洗、指标选择与计分步骤整理为可复用流程，并分别应用于All of Us、HRS和NHANES。它的主要价值是让方法选择可追溯，而非验证一个新的临床诊断分数。",
    "rights": "© The Allostasis Project。保留所有权利。除法律允许的例外外，转载或改编需另行授权。",
    "version": "1.0",
    "updatedAt": "2026-10-29",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
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      "updatedAt": "2026-10-29",
      "version": "1.0",
      "byline": "team",
      "author": null,
      "reviewer": null,
      "workflow": {
        "ai": {
          "usage": "used",
          "system": "OpenAI Codex",
          "scope": "Assisted source comparison, evidence extraction and bilingual research-note preparation. The materials consulted and unresolved scientific issues are specified in each note.",
          "version": "1.0",
          "tasks": [
            "Source comparison and evidence extraction",
            "Bilingual research-note drafting and editorial comparison"
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      "revisions": [
        {
          "date": "2026-10-29",
          "version": "1.0",
          "description": "新增跨数据库适应负荷流程导读，保留CRP阈值的待核差异。"
        }
      ]
    },
    "original": {
      "id": "beese-2026",
      "title": "Allostatic (over) load measurement: Workflow and repository",
      "authors": "Beese S · Cross J · Rice D · DeJong TL",
      "journal": "PLOS One",
      "year": "2026",
      "url": "https://doi.org/10.1371/journal.pone.0360639",
      "doi": "10.1371/journal.pone.0360639",
      "pmid": "42905797"
    },
    "references": [
      {
        "id": "beese-2026",
        "title": "Allostatic (over) load measurement: Workflow and repository",
        "authors": "Beese S · Cross J · Rice D · DeJong TL",
        "journal": "PLOS One",
        "year": "2026",
        "url": "https://doi.org/10.1371/journal.pone.0360639",
        "doi": "10.1371/journal.pone.0360639",
        "pmid": "42905797"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "研究发现",
        "paragraphs": [
          "论文把适应负荷的资料清洗、指标选择与计分步骤整理为可复用流程，并分别应用于All of Us、HRS和NHANES。它的主要价值是让方法选择可追溯，而非验证一个新的临床诊断分数。"
        ]
      },
      {
        "id": "limits",
        "title": "范围与局限",
        "paragraphs": [
          "三个数据库分别处理；All of Us流程样本为37,866人，未把三库个体数据合并为一个样本。",
          "样本内分位阈值会随人群与检测方式变化。表9的CRP截点为14.20、4.29和4.14，变异系数为0.7638，与正文有关异质性的概括仍需对照单位和所指对象。这是待核的不一致，并非正式勘误；不宜据此确认三库阈值可互换。"
        ]
      },
      {
        "id": "sample",
        "title": "研究人群与样本",
        "paragraphs": [
          "三个数据库分别处理；All of Us流程样本为37,866人，未把三库个体数据合并为一个样本。"
        ]
      },
      {
        "id": "exposure",
        "title": "暴露或干预",
        "paragraphs": [
          "五项标志物的数据库清洗与分位风险计分；使用NHANES历史极值辅助设定合理范围，并讨论临床截点敏感性分析。"
        ]
      },
      {
        "id": "outcomes",
        "title": "观察结局",
        "paragraphs": [
          "处理流程、保留样本和标志物阈值；没有统一的临床效度终点。"
        ]
      },
      {
        "id": "duration",
        "title": "时间范围",
        "paragraphs": [
          "各数据库观察时期不同；研究关注测量流程，而非一次干预后的恢复时程。"
        ]
      },
      {
        "id": "funding",
        "title": "研究资金来源",
        "paragraphs": [
          "作者报告本项工作没有特定资助。"
        ]
      },
      {
        "id": "conflicts",
        "title": "研究利益关系",
        "paragraphs": [
          "作者声明无竞争性利益。"
        ]
      },
      {
        "id": "basis",
        "title": "导读范围",
        "paragraphs": [
          "全文方法、清洗与计分流程、表3和表9及局限部分；代码、复杂抽样权重和全部附件尚未逐项复核。"
        ],
        "links": [
          {
            "label": "PubMed Central全文",
            "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13686455/"
          }
        ]
      }
    ]
  }
}