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    "key": "kleckner-2017",
    "id": "TAP-RDN-0049",
    "locale": "en",
    "path": "/research/kleckner-2017/",
    "title": "TAP reading note: Evidence for a Large-Scale Brain System Supporting Allostasis and Interoception in Humans",
    "description": "Combining macaque tracing literature with human resting-state connectivity, the study proposes a large-scale system supporting allostasis and interoception. In a separate human sample, connectivity was associated with correspondence between subjective arousal and skin-conductance responses to images, providing correlational support for the proposed network.",
    "rights": "© The Allostasis Project. All rights reserved. Reproduction or adaptation requires separate permission, subject to applicable legal exceptions.",
    "version": "1.0",
    "updatedAt": "2026-10-29",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-10-29",
      "version": "1.0",
      "byline": "team",
      "author": null,
      "reviewer": null,
      "workflow": {
        "ai": {
          "usage": "used",
          "system": "OpenAI Codex",
          "scope": "Assisted source comparison, evidence extraction and bilingual research-note preparation. The materials consulted and unresolved scientific issues are specified in each note.",
          "version": "1.0",
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            "Source comparison and evidence extraction",
            "Bilingual research-note drafting and editorial comparison"
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      "revisions": [
        {
          "date": "2026-10-29",
          "version": "1.0",
          "description": "Added the network evidence and distinctions between connectivity, regulation and individual measurement validity."
        }
      ]
    },
    "original": {
      "id": "kleckner-2017",
      "title": "Evidence for a Large-Scale Brain System Supporting Allostasis and Interoception in Humans",
      "authors": "Kleckner IR · Zhang J · Touroutoglou A · Chanes L · Xia C · Simmons WK · Quigley KS · Dickerson BC · Barrett LF",
      "journal": "Nature Human Behaviour",
      "year": "2017",
      "url": "https://doi.org/10.1038/s41562-017-0069",
      "doi": "10.1038/s41562-017-0069",
      "pmid": "28983518"
    },
    "references": [
      {
        "id": "kleckner-2017",
        "title": "Evidence for a Large-Scale Brain System Supporting Allostasis and Interoception in Humans",
        "authors": "Kleckner IR · Zhang J · Touroutoglou A · Chanes L · Xia C · Simmons WK · Quigley KS · Dickerson BC · Barrett LF",
        "journal": "Nature Human Behaviour",
        "year": "2017",
        "url": "https://doi.org/10.1038/s41562-017-0069",
        "doi": "10.1038/s41562-017-0069",
        "pmid": "28983518"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "What the study found",
        "paragraphs": [
          "Combining macaque tracing literature with human resting-state connectivity, the study proposes a large-scale system supporting allostasis and interoception. In a separate human sample, connectivity was associated with correspondence between subjective arousal and skin-conductance responses to images, providing correlational support for the proposed network."
        ]
      },
      {
        "id": "limits",
        "title": "Scope & limitations",
        "paragraphs": [
          "Discovery sample of 280 and replication sample of 270; 41 of 66 participants in the validation study had usable imaging and skin-conductance data.",
          "Functional connectivity does not establish direct anatomical connections or causal regulation. Vascular effects, brainstem resolution, cross-species mapping and sample selection constrain interpretation. Energy expenditure, allostatic load and individual recovery scores were not directly validated."
        ]
      },
      {
        "id": "sample",
        "title": "Population & sample",
        "paragraphs": [
          "Discovery sample of 280 and replication sample of 270; 41 of 66 participants in the validation study had usable imaging and skin-conductance data."
        ]
      },
      {
        "id": "exposure",
        "title": "Exposure or intervention",
        "paragraphs": [
          "Resting-state fMRI and an image-evoked arousal task, interpreted alongside cross-species anatomical literature."
        ]
      },
      {
        "id": "outcomes",
        "title": "Outcomes",
        "paragraphs": [
          "Connectivity and correspondence between subjective and physiological arousal; the reported association test had P=.003."
        ]
      },
      {
        "id": "duration",
        "title": "Time frame",
        "paragraphs": [
          "Imaging and laboratory-task measurements, without long-term clinical follow-up."
        ]
      },
      {
        "id": "funding",
        "title": "Research funding",
        "paragraphs": [
          "NIA R01 AG030311; US Army Research Institute W5J9CQ-11-C-0046 and W5J9CQ-12-C-0049; NIMH F32MH096533 and K01MH096175-01; NCI UG1 CA189961 and R25 CA102618; additional Oklahoma Tobacco Research Center and Fonds de recherche santé Québec fellowship support."
        ]
      },
      {
        "id": "conflicts",
        "title": "Research conflicts of interest",
        "paragraphs": [
          "The authors declare no competing interests and report no funder involvement in study design or the publication decision."
        ]
      },
      {
        "id": "basis",
        "title": "Reading scope",
        "paragraphs": [
          "Full-text discovery, replication, validation, limitations and disclosures. Supplementary discussion and sensitivity to sample exclusions remain to be examined."
        ],
        "links": [
          {
            "label": "Full text in PubMed Central",
            "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC5624222/"
          }
        ]
      }
    ]
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}