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  "capturedAt": "2026-10-29T10:31:13.708Z",
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  "work": {
    "type": "RDN",
    "kind": "note",
    "key": "kleckner-2017",
    "id": "TAP-RDN-0049",
    "locale": "zh",
    "path": "/zh/research/kleckner-2017/",
    "title": "TAP 导读: Evidence for a Large-Scale Brain System Supporting Allostasis and Interoception in Humans",
    "description": "研究结合猕猴示踪文献与人类静息态功能连接，提出一个支持异稳态调节与内感受的大规模脑系统。独立人类样本中，部分连接与图片引发的主观唤醒和皮电反应之间的一致性有关，为这一网络假说提供了相关性证据。",
    "rights": "© The Allostasis Project。保留所有权利。除法律允许的例外外，转载或改编需另行授权。",
    "version": "1.0",
    "updatedAt": "2026-10-29",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-10-29",
      "version": "1.0",
      "byline": "team",
      "author": null,
      "reviewer": null,
      "workflow": {
        "ai": {
          "usage": "used",
          "system": "OpenAI Codex",
          "scope": "Assisted source comparison, evidence extraction and bilingual research-note preparation. The materials consulted and unresolved scientific issues are specified in each note.",
          "version": "1.0",
          "tasks": [
            "Source comparison and evidence extraction",
            "Bilingual research-note drafting and editorial comparison"
          ]
        }
      },
      "revisions": [
        {
          "date": "2026-10-29",
          "version": "1.0",
          "description": "新增脑网络证据，并区分功能连接、调节机制与个人测量效度。"
        }
      ]
    },
    "original": {
      "id": "kleckner-2017",
      "title": "Evidence for a Large-Scale Brain System Supporting Allostasis and Interoception in Humans",
      "authors": "Kleckner IR · Zhang J · Touroutoglou A · Chanes L · Xia C · Simmons WK · Quigley KS · Dickerson BC · Barrett LF",
      "journal": "Nature Human Behaviour",
      "year": "2017",
      "url": "https://doi.org/10.1038/s41562-017-0069",
      "doi": "10.1038/s41562-017-0069",
      "pmid": "28983518"
    },
    "references": [
      {
        "id": "kleckner-2017",
        "title": "Evidence for a Large-Scale Brain System Supporting Allostasis and Interoception in Humans",
        "authors": "Kleckner IR · Zhang J · Touroutoglou A · Chanes L · Xia C · Simmons WK · Quigley KS · Dickerson BC · Barrett LF",
        "journal": "Nature Human Behaviour",
        "year": "2017",
        "url": "https://doi.org/10.1038/s41562-017-0069",
        "doi": "10.1038/s41562-017-0069",
        "pmid": "28983518"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "研究发现",
        "paragraphs": [
          "研究结合猕猴示踪文献与人类静息态功能连接，提出一个支持异稳态调节与内感受的大规模脑系统。独立人类样本中，部分连接与图片引发的主观唤醒和皮电反应之间的一致性有关，为这一网络假说提供了相关性证据。"
        ]
      },
      {
        "id": "limits",
        "title": "范围与局限",
        "paragraphs": [
          "人类发现样本280人、复现样本270人；效度研究66人中41人同时具有合格影像和皮电资料。",
          "功能连接不等于直接解剖连接或因果调节。血管因素、脑干成像分辨率、跨物种映射与效度样本筛选都会影响解释；研究没有直接测量能量消耗或适应负荷，也未验证个人恢复分数。"
        ]
      },
      {
        "id": "sample",
        "title": "研究人群与样本",
        "paragraphs": [
          "人类发现样本280人、复现样本270人；效度研究66人中41人同时具有合格影像和皮电资料。"
        ]
      },
      {
        "id": "exposure",
        "title": "暴露或干预",
        "paragraphs": [
          "静息态fMRI网络分析及图片诱发唤醒任务，结合跨物种解剖文献。"
        ]
      },
      {
        "id": "outcomes",
        "title": "观察结局",
        "paragraphs": [
          "功能连接及主客观唤醒一致性；报告的相关检验P=.003。"
        ]
      },
      {
        "id": "duration",
        "title": "时间范围",
        "paragraphs": [
          "影像与实验任务期间的测量；没有临床结局长期随访。"
        ]
      },
      {
        "id": "funding",
        "title": "研究资金来源",
        "paragraphs": [
          "NIA R01 AG030311；美国陆军研究所W5J9CQ-11-C-0046与W5J9CQ-12-C-0049；NIMH F32MH096533与K01MH096175-01；NCI UG1 CA189961与R25 CA102618；另有Oklahoma Tobacco Research Center及Fonds de recherche santé Québec奖学金支持。"
        ]
      },
      {
        "id": "conflicts",
        "title": "研究利益关系",
        "paragraphs": [
          "作者声明无竞争利益，并报告资助方未参与研究设计及发表决策。"
        ]
      },
      {
        "id": "basis",
        "title": "导读范围",
        "paragraphs": [
          "全文发现、复现、效度样本、功能验证、局限与披露；补充讨论及样本排除的敏感性分析尚待核读。"
        ],
        "links": [
          {
            "label": "PubMed Central全文",
            "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC5624222/"
          }
        ]
      }
    ]
  }
}