{
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  "capturedAt": "2026-10-29T10:31:13.709Z",
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  "work": {
    "type": "RDN",
    "kind": "note",
    "key": "adam-2017",
    "id": "TAP-RDN-0051",
    "locale": "zh",
    "path": "/zh/research/adam-2017/",
    "title": "TAP 导读: Diurnal cortisol slopes and mental and physical health outcomes: A systematic review and meta-analysis",
    "description": "较平缓的日间皮质醇下降与较差健康有小幅平均关联：总体r=.147（95%CI .112—.183），前瞻研究r=.138（.005—.267）。这些结果适合用来研究日节律与健康的联系，不能单凭一次测量诊断个人压力。",
    "rights": "© The Allostasis Project。保留所有权利。除法律允许的例外外，转载或改编需另行授权。",
    "version": "1.0",
    "updatedAt": "2026-10-29",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-10-29",
      "version": "1.0",
      "byline": "team",
      "author": null,
      "reviewer": null,
      "workflow": {
        "ai": {
          "usage": "used",
          "system": "OpenAI Codex",
          "scope": "Assisted source comparison, evidence extraction and bilingual research-note preparation. The materials consulted and unresolved scientific issues are specified in each note.",
          "version": "1.0",
          "tasks": [
            "Source comparison and evidence extraction",
            "Bilingual research-note drafting and editorial comparison"
          ]
        }
      },
      "revisions": [
        {
          "date": "2026-10-29",
          "version": "1.0",
          "description": "新增日间皮质醇斜率导读，保留高异质性及死亡区间与文字不一致。"
        }
      ]
    },
    "original": {
      "id": "adam-2017",
      "title": "Diurnal cortisol slopes and mental and physical health outcomes: A systematic review and meta-analysis",
      "authors": "Adam EK · Quinn ME · Tavernier R · McQuillan MT · Dahlke KA · Gilbert KE",
      "journal": "Psychoneuroendocrinology",
      "year": "2017",
      "url": "https://doi.org/10.1016/j.psyneuen.2017.05.018",
      "doi": "10.1016/j.psyneuen.2017.05.018",
      "pmid": "28578301"
    },
    "references": [
      {
        "id": "adam-2017",
        "title": "Diurnal cortisol slopes and mental and physical health outcomes: A systematic review and meta-analysis",
        "authors": "Adam EK · Quinn ME · Tavernier R · McQuillan MT · Dahlke KA · Gilbert KE",
        "journal": "Psychoneuroendocrinology",
        "year": "2017",
        "url": "https://doi.org/10.1016/j.psyneuen.2017.05.018",
        "doi": "10.1016/j.psyneuen.2017.05.018",
        "pmid": "28578301"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "研究发现",
        "paragraphs": [
          "较平缓的日间皮质醇下降与较差健康有小幅平均关联：总体r=.147（95%CI .112—.183），前瞻研究r=.138（.005—.267）。这些结果适合用来研究日节律与健康的联系，不能单凭一次测量诊断个人压力。"
        ]
      },
      {
        "id": "limits",
        "title": "范围与局限",
        "paragraphs": [
          "80项研究、179个关联估计，涉及不同心理与身体健康结局。",
          "总体异质性较高（I²=83.23%）；效应换算、混杂调整和发表偏倚处理并不一致。死亡分析经发表偏倚调整后HR=1.69（.55—5.2），区间跨1，正文仍称显著；这一内部不一致待核，不能据此表述为稳健的显著死亡风险。"
        ]
      },
      {
        "id": "sample",
        "title": "研究人群与样本",
        "paragraphs": [
          "80项研究、179个关联估计，涉及不同心理与身体健康结局。"
        ]
      },
      {
        "id": "exposure",
        "title": "暴露或干预",
        "paragraphs": [
          "比较较平缓与较陡的日间皮质醇斜率；同研究多个结局先汇总后合并。"
        ]
      },
      {
        "id": "outcomes",
        "title": "观察结局",
        "paragraphs": [
          "心理与身体健康、前瞻健康结局及死亡；不把不同结局合为个人风险分数。"
        ]
      },
      {
        "id": "duration",
        "title": "时间范围",
        "paragraphs": [
          "检索截至2015年1月31日；原研究包括横断面和不同随访长度的前瞻设计。"
        ]
      },
      {
        "id": "funding",
        "title": "研究资金来源",
        "paragraphs": [
          "Northwestern大学Institute for Policy Research的教员和研究生支持等，详见论文致谢。"
        ]
      },
      {
        "id": "conflicts",
        "title": "研究利益关系",
        "paragraphs": [
          "作者声明无利益冲突，并报告资助方未参与分析与解释。"
        ]
      },
      {
        "id": "basis",
        "title": "导读范围",
        "paragraphs": [
          "全文选择与合成方法、总体/前瞻/死亡结果及局限；死亡原始研究与合并脚本尚待核对。"
        ],
        "links": [
          {
            "label": "PubMed Central全文",
            "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC5568897/"
          }
        ]
      }
    ]
  }
}