{
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  "work": {
    "type": "RDN",
    "kind": "note",
    "key": "pyrkov-2021",
    "id": "TAP-RDN-0052",
    "locale": "zh",
    "path": "/zh/research/pyrkov-2021/",
    "title": "TAP 导读: Longitudinal analysis of blood markers reveals progressive loss of resilience and predicts human lifespan limit",
    "description": "研究用血细胞指标构建DOSI，并观察其波动自相关随年龄变化。年龄分组的相关时间约为2—8周，支持把动态变化作为候选衰老指标。标题中的120—150岁来自模型向未观察年龄的外推，不是直接测得的人类寿命上限。",
    "rights": "© The Allostasis Project。保留所有权利。除法律允许的例外外，转载或改编需另行授权。",
    "version": "1.0",
    "updatedAt": "2026-10-29",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-10-29",
      "version": "1.0",
      "byline": "team",
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      "reviewer": null,
      "workflow": {
        "ai": {
          "usage": "used",
          "system": "OpenAI Codex",
          "scope": "Assisted source comparison, evidence extraction and bilingual research-note preparation. The materials consulted and unresolved scientific issues are specified in each note.",
          "version": "1.0",
          "tasks": [
            "Source comparison and evidence extraction",
            "Bilingual research-note drafting and editorial comparison"
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      },
      "revisions": [
        {
          "date": "2026-10-29",
          "version": "1.0",
          "description": "新增动态衰老指标导读，明确寿命外推与实测恢复的区别。"
        }
      ]
    },
    "original": {
      "id": "pyrkov-2021",
      "title": "Longitudinal analysis of blood markers reveals progressive loss of resilience and predicts human lifespan limit",
      "authors": "Pyrkov TV · Avchaciov K · Tarkhov AE · Menshikov LI · Gudkov AV · Fedichev PO",
      "journal": "Nature Communications",
      "year": "2021",
      "url": "https://doi.org/10.1038/s41467-021-23014-1",
      "doi": "10.1038/s41467-021-23014-1",
      "pmid": "34035236"
    },
    "references": [
      {
        "id": "pyrkov-2021",
        "title": "Longitudinal analysis of blood markers reveals progressive loss of resilience and predicts human lifespan limit",
        "authors": "Pyrkov TV · Avchaciov K · Tarkhov AE · Menshikov LI · Gudkov AV · Fedichev PO",
        "journal": "Nature Communications",
        "year": "2021",
        "url": "https://doi.org/10.1038/s41467-021-23014-1",
        "doi": "10.1038/s41467-021-23014-1",
        "pmid": "34035236"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "研究发现",
        "paragraphs": [
          "研究用血细胞指标构建DOSI，并观察其波动自相关随年龄变化。年龄分组的相关时间约为2—8周，支持把动态变化作为候选衰老指标。标题中的120—150岁来自模型向未观察年龄的外推，不是直接测得的人类寿命上限。"
        ]
      },
      {
        "id": "limits",
        "title": "范围与局限",
        "paragraphs": [
          "NHANES建模、UK Biobank验证；纵向血细胞资料原有1,082人，按DOSI筛选后的407人用于非高脆弱组动态分析；另有活动数据。",
          "部分纵向资料缺少临床状态，按DOSI选择样本也会影响结果。群体平均自相关时间不同于个人经历明确应激后的实测恢复时间；模型的高龄线性外推不能确定生物学硬上限。"
        ]
      },
      {
        "id": "sample",
        "title": "研究人群与样本",
        "paragraphs": [
          "NHANES建模、UK Biobank验证；纵向血细胞资料原有1,082人，按DOSI筛选后的407人用于非高脆弱组动态分析；另有活动数据。"
        ]
      },
      {
        "id": "exposure",
        "title": "暴露或干预",
        "paragraphs": [
          "血细胞指标死亡风险建模、重复测量自相关及活动序列比较。"
        ]
      },
      {
        "id": "outcomes",
        "title": "观察结局",
        "paragraphs": [
          "死亡模型C-index：训练.68、测试.67、UK Biobank .65；另分析动态波动和年龄关系。"
        ]
      },
      {
        "id": "duration",
        "title": "时间范围",
        "paragraphs": [
          "不同来源的重复测量和随访；模型相关时间以周计，寿命外推超出观察年龄。"
        ]
      },
      {
        "id": "funding",
        "title": "研究资金来源",
        "paragraphs": [
          "Gero PTE支持。"
        ]
      },
      {
        "id": "conflicts",
        "title": "研究利益关系",
        "paragraphs": [
          "多位作者为Gero员工，另有股东及顾问委员会关系。"
        ]
      },
      {
        "id": "basis",
        "title": "导读范围",
        "paragraphs": [
          "全文DOSI动态、方法、图3、寿命外推与披露；全部数据处理和敏感性分析尚未独立复算。"
        ],
        "links": [
          {
            "label": "PubMed Central全文",
            "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8149842/"
          }
        ]
      }
    ]
  }
}