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    "type": "RDN",
    "kind": "note",
    "key": "thayer-2012",
    "id": "TAP-RDN-0053",
    "locale": "en",
    "path": "/research/thayer-2012/",
    "title": "TAP reading note: A meta-analysis of heart rate variability and neuroimaging studies: implications for heart rate variability as a marker of stress and health",
    "description": "This coordinate meta-analysis links HRV with activity in regions including the anterior cingulate, extended amygdala and ventral striatum, informing the neurovisceral-integration account. Findings differed between emotional and cognitive/motor tasks, indicating that neural associations depend on context.",
    "rights": "© The Allostasis Project. All rights reserved. Reproduction or adaptation requires separate permission, subject to applicable legal exceptions.",
    "version": "1.0",
    "updatedAt": "2026-10-29",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-10-29",
      "version": "1.0",
      "byline": "team",
      "author": null,
      "reviewer": null,
      "workflow": {
        "ai": {
          "usage": "used",
          "system": "OpenAI Codex",
          "scope": "Assisted source comparison, evidence extraction and bilingual research-note preparation. The materials consulted and unresolved scientific issues are specified in each note.",
          "version": "1.0",
          "tasks": [
            "Source comparison and evidence extraction",
            "Bilingual research-note drafting and editorial comparison"
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      "revisions": [
        {
          "date": "2026-10-29",
          "version": "1.0",
          "description": "Added HRV neuroimaging evidence with its illustrative selection and correlational scope."
        }
      ]
    },
    "original": {
      "id": "thayer-2012",
      "title": "A meta-analysis of heart rate variability and neuroimaging studies: implications for heart rate variability as a marker of stress and health",
      "authors": "Thayer JF · Ahs F · Fredrikson M · Sollers JJ · Wager TD",
      "journal": "Neuroscience & Biobehavioral Reviews",
      "year": "2012",
      "url": "https://doi.org/10.1016/j.neubiorev.2011.11.009",
      "doi": "10.1016/j.neubiorev.2011.11.009",
      "pmid": "22178086"
    },
    "references": [
      {
        "id": "thayer-2012",
        "title": "A meta-analysis of heart rate variability and neuroimaging studies: implications for heart rate variability as a marker of stress and health",
        "authors": "Thayer JF · Ahs F · Fredrikson M · Sollers JJ · Wager TD",
        "journal": "Neuroscience & Biobehavioral Reviews",
        "year": "2012",
        "url": "https://doi.org/10.1016/j.neubiorev.2011.11.009",
        "doi": "10.1016/j.neubiorev.2011.11.009",
        "pmid": "22178086"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "What the study found",
        "paragraphs": [
          "This coordinate meta-analysis links HRV with activity in regions including the anterior cingulate, extended amygdala and ventral striatum, informing the neurovisceral-integration account. Findings differed between emotional and cognitive/motor tasks, indicating that neural associations depend on context."
        ]
      },
      {
        "id": "limits",
        "title": "Scope & limitations",
        "paragraphs": [
          "8 PET/fMRI studies, 191 participants and 10 contrasts.",
          "The authors describe an illustrative rather than exhaustive selection. Studies were small and heterogeneous, with HRV recorded both inside and outside scanners. Spatial convergence and correlation do not establish a specific top-down causal mechanism or diagnose psychological traits."
        ]
      },
      {
        "id": "sample",
        "title": "Population & sample",
        "paragraphs": [
          "8 PET/fMRI studies, 191 participants and 10 contrasts."
        ]
      },
      {
        "id": "exposure",
        "title": "Exposure or intervention",
        "paragraphs": [
          "Multilevel kernel-density coordinate analysis with sample-size weighting and whole-brain multiple-comparison control."
        ]
      },
      {
        "id": "outcomes",
        "title": "Outcomes",
        "paragraphs": [
          "Spatial associations between HRV and regional brain activity, including task differences."
        ]
      },
      {
        "id": "duration",
        "title": "Time frame",
        "paragraphs": [
          "Study-specific scan and task periods; no common clinical follow-up."
        ]
      },
      {
        "id": "funding",
        "title": "Research funding",
        "paragraphs": [
          "Not yet verified against the full text."
        ]
      },
      {
        "id": "conflicts",
        "title": "Research conflicts of interest",
        "paragraphs": [
          "Not yet verified against the full text."
        ]
      },
      {
        "id": "basis",
        "title": "Reading scope",
        "paragraphs": [
          "Original full-text methods, Tables 1/2 and neurovisceral-integration discussion. The eight original reports and coordinate dependencies have not been individually rechecked."
        ]
      }
    ]
  }
}