{
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  "capturedAt": "2026-10-29T10:31:13.716Z",
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  "work": {
    "type": "RDN",
    "kind": "note",
    "key": "molenaar-2023",
    "id": "TAP-RDN-0065",
    "locale": "zh",
    "path": "/zh/research/molenaar-2023/",
    "title": "TAP 导读: Effect of Multimodal Prehabilitation on Reducing Postoperative Complications and Enhancing Functional Capacity Following Colorectal Cancer Surgery: The PREHAB Randomized Clinical Trial",
    "description": "PREHAB试验中，四周多模式预康复组的严重并发症较少：按CCI>20定义，21/123对38/128，调整OR=.47（95%CI .26—.87）。但另一共同主要结局——术后四周六分钟步行距离——组间差15.6米（−1.4—32.6）未达显著。两项结局应分别解读。",
    "rights": "© The Allostasis Project。保留所有权利。除法律允许的例外外，转载或改编需另行授权。",
    "version": "1.0",
    "updatedAt": "2026-10-29",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-10-29",
      "version": "1.0",
      "byline": "team",
      "author": null,
      "reviewer": null,
      "workflow": {
        "ai": {
          "usage": "used",
          "system": "OpenAI Codex",
          "scope": "Assisted source comparison, evidence extraction and bilingual research-note preparation. The materials consulted and unresolved scientific issues are specified in each note.",
          "version": "1.0",
          "tasks": [
            "Source comparison and evidence extraction",
            "Bilingual research-note drafting and editorial comparison"
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      "revisions": [
        {
          "date": "2026-10-29",
          "version": "1.0",
          "description": "新增PREHAB试验，分别呈现两个主要结局并链接图3D更正。"
        }
      ]
    },
    "original": {
      "id": "molenaar-2023",
      "title": "Effect of Multimodal Prehabilitation on Reducing Postoperative Complications and Enhancing Functional Capacity Following Colorectal Cancer Surgery: The PREHAB Randomized Clinical Trial",
      "authors": "Molenaar CJL · Minnella EM · Coca-Martinez M · Ten Cate DWG · Regis M · Awasthi R · Martínez-Palli G · López-Baamonde M · Sebio-Garcia R · Feo CV · van Rooijen SJ · Schreinemakers JMJ · Bojesen RD · Gögenur I · van den Heuvel ER · Carli F · Slooter GD · PREHAB Study Group",
      "journal": "JAMA Surgery",
      "year": "2023",
      "url": "https://doi.org/10.1001/jamasurg.2023.0198",
      "doi": "10.1001/jamasurg.2023.0198",
      "pmid": "36988937"
    },
    "references": [
      {
        "id": "molenaar-2023",
        "title": "Effect of Multimodal Prehabilitation on Reducing Postoperative Complications and Enhancing Functional Capacity Following Colorectal Cancer Surgery: The PREHAB Randomized Clinical Trial",
        "authors": "Molenaar CJL · Minnella EM · Coca-Martinez M · Ten Cate DWG · Regis M · Awasthi R · Martínez-Palli G · López-Baamonde M · Sebio-Garcia R · Feo CV · van Rooijen SJ · Schreinemakers JMJ · Bojesen RD · Gögenur I · van den Heuvel ER · Carli F · Slooter GD · PREHAB Study Group",
        "journal": "JAMA Surgery",
        "year": "2023",
        "url": "https://doi.org/10.1001/jamasurg.2023.0198",
        "doi": "10.1001/jamasurg.2023.0198",
        "pmid": "36988937"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "研究发现",
        "paragraphs": [
          "PREHAB试验中，四周多模式预康复组的严重并发症较少：按CCI>20定义，21/123对38/128，调整OR=.47（95%CI .26—.87）。但另一共同主要结局——术后四周六分钟步行距离——组间差15.6米（−1.4—32.6）未达显著。两项结局应分别解读。"
        ]
      },
      {
        "id": "limits",
        "title": "范围与局限",
        "paragraphs": [
          "7中心、非转移性结直肠癌手术患者；269人随机，18人随机后排除，251人纳入作者称为意向治疗的分析，中位年龄69岁。",
          "计划714人，因疫情提前停止；CCI因分布偏斜改为二分类分析，四周步行结局约三分之一缺失。2023年更正为图3D预康复组术前及四周数据补上显著性上标；不能用八周次要结果替代四周共同主要结果。"
        ]
      },
      {
        "id": "sample",
        "title": "研究人群与样本",
        "paragraphs": [
          "7中心、非转移性结直肠癌手术患者；269人随机，18人随机后排除，251人纳入作者称为意向治疗的分析，中位年龄69岁。"
        ]
      },
      {
        "id": "exposure",
        "title": "暴露或干预",
        "paragraphs": [
          "四周监督运动、营养和心理支持等预康复，加标准增强恢复路径，与标准照护比较。"
        ]
      },
      {
        "id": "outcomes",
        "title": "观察结局",
        "paragraphs": [
          "30日CCI及术后四周六分钟步行距离为共同主要结局；连续CCI比较P=.06。报告7例轻微干预不良反应，无严重干预不良反应。"
        ]
      },
      {
        "id": "duration",
        "title": "时间范围",
        "paragraphs": [
          "术前四周；主要结局为术后30日并发症与四周步行，另有后续测量。"
        ]
      },
      {
        "id": "funding",
        "title": "研究资金来源",
        "paragraphs": [
          "Dutch Cancer Society和Johnson & Johnson等支持；FrieslandCampina与Immunotec供蛋白，Philips借用设备。"
        ]
      },
      {
        "id": "conflicts",
        "title": "研究利益关系",
        "paragraphs": [
          "部分作者披露Dompé、Pharmacosmos、Intuitive、Ethicon等关系；论文报告资助方未参与研究决策。"
        ]
      },
      {
        "id": "basis",
        "title": "导读范围",
        "paragraphs": [
          "原刊PDF正文及2023年5月3日正式更正；所查PDF早于更正，图3D需配合通知阅读。方案、统计分析计划和全部缺失值敏感性附件尚待核。"
        ],
        "links": [
          {
            "label": "PubMed Central全文",
            "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10061316/"
          },
          {
            "label": "正式更正：图3D标注",
            "url": "https://jamanetwork.com/journals/jamasurgery/fullarticle/2804492"
          },
          {
            "label": "对照阅读相关原始研究及其方法",
            "url": "https://doi.org/10.1001/jamasurg.2019.5474"
          }
        ]
      }
    ]
  }
}