{
  "schemaVersion": 1,
  "capturedAt": "2026-10-29T10:31:13.700Z",
  "sha256": "a25cbe1c6179e768af7191936906e8bf310343aed74e678778f68f6897fa2bca",
  "work": {
    "type": "RDN",
    "kind": "note",
    "key": "fried-2001",
    "id": "TAP-RDN-0067",
    "locale": "zh",
    "path": "/zh/research/fried-2001/",
    "title": "TAP 导读: Frailty in older adults: evidence for a phenotype",
    "description": "Fried等以体重下降、耗竭、低握力、慢步速和低活动五项构建衰弱表型，三项及以上定义为衰弱。该表型与后来死亡、住院和日常活动能力下降相关，为识别老年脆弱状态提供了可操作框架；它不是直接测量扰动后的动态恢复。",
    "rights": "© The Allostasis Project。保留所有权利。除法律允许的例外外，转载或改编需另行授权。",
    "version": "1.0",
    "updatedAt": "2026-10-29",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-10-29",
      "version": "1.0",
      "byline": "team",
      "author": null,
      "reviewer": null,
      "workflow": {
        "ai": {
          "usage": "used",
          "system": "OpenAI Codex",
          "scope": "Assisted source comparison, evidence extraction and bilingual research-note preparation. The materials consulted and unresolved scientific issues are specified in each note.",
          "version": "1.0",
          "tasks": [
            "Source comparison and evidence extraction",
            "Bilingual research-note drafting and editorial comparison"
          ]
        }
      },
      "revisions": [
        {
          "date": "2026-10-29",
          "version": "1.0",
          "description": "新增衰弱表型与前瞻结局，区分静态表型和动态恢复，并保留跌倒结果的不确定性。"
        }
      ]
    },
    "original": {
      "id": "fried-2001",
      "title": "Frailty in older adults: evidence for a phenotype",
      "authors": "Fried LP · Tangen CM · Walston J · Newman AB · Hirsch C · Gottdiener J · Seeman T · Tracy R · Kop WJ · Burke G · McBurnie MA · Cardiovascular Health Study Collaborative Research Group",
      "journal": "The Journals of Gerontology Series A: Biological Sciences and Medical Sciences",
      "year": "2001",
      "url": "https://doi.org/10.1093/gerona/56.3.m146",
      "doi": "10.1093/gerona/56.3.m146",
      "pmid": "11253156"
    },
    "references": [
      {
        "id": "fried-2001",
        "title": "Frailty in older adults: evidence for a phenotype",
        "authors": "Fried LP · Tangen CM · Walston J · Newman AB · Hirsch C · Gottdiener J · Seeman T · Tracy R · Kop WJ · Burke G · McBurnie MA · Cardiovascular Health Study Collaborative Research Group",
        "journal": "The Journals of Gerontology Series A: Biological Sciences and Medical Sciences",
        "year": "2001",
        "url": "https://doi.org/10.1093/gerona/56.3.m146",
        "doi": "10.1093/gerona/56.3.m146",
        "pmid": "11253156"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "研究发现",
        "paragraphs": [
          "Fried等以体重下降、耗竭、低握力、慢步速和低活动五项构建衰弱表型，三项及以上定义为衰弱。该表型与后来死亡、住院和日常活动能力下降相关，为识别老年脆弱状态提供了可操作框架；它不是直接测量扰动后的动态恢复。"
        ]
      },
      {
        "id": "limits",
        "title": "范围与局限",
        "paragraphs": [
          "CHS的5,317名社区成年人，年龄≥65岁；两个入组队列，衰弱患病率6.9%。",
          "观察性设计、既有可用变量、部分自报指标及特定疾病排除限制推广。表7三年跌倒HR=1.29（95%CI 1.00—1.68），P=.054，不能把所有结局都称为显著。性别、体型相关阈值应核对原文后再考虑应用。"
        ]
      },
      {
        "id": "sample",
        "title": "研究人群与样本",
        "paragraphs": [
          "CHS的5,317名社区成年人，年龄≥65岁；两个入组队列，衰弱患病率6.9%。"
        ]
      },
      {
        "id": "exposure",
        "title": "暴露或干预",
        "paragraphs": [
          "五项表型；1—2项为中间状态，≥3项为衰弱，与非衰弱者比较。"
        ]
      },
      {
        "id": "outcomes",
        "title": "观察结局",
        "paragraphs": [
          "三年调整死亡HR=2.24（1.51—3.33），住院1.29（1.09—1.54），ADL恶化1.98（1.54—2.55）；跌倒结果另列。"
        ]
      },
      {
        "id": "duration",
        "title": "时间范围",
        "paragraphs": [
          "两个入组队列分别随访7年与4年；上述表7风险比较为三年。"
        ]
      },
      {
        "id": "funding",
        "title": "研究资金来源",
        "paragraphs": [
          "NHLBI/NIH的多项Cardiovascular Health Study合同支持，详见原文。"
        ]
      },
      {
        "id": "conflicts",
        "title": "研究利益关系",
        "paragraphs": [
          "独立利益声明尚未核实。"
        ]
      },
      {
        "id": "basis",
        "title": "导读范围",
        "paragraphs": [
          "原刊PDF第M146—M154页；性别、BMI和身高分层的阈值附录尚待逐项核读。"
        ]
      }
    ]
  }
}