{
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  "capturedAt": "2026-10-30T05:58:56.804Z",
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  "work": {
    "kind": "note",
    "key": "redondo-sanchez-2026",
    "type": "RDN",
    "id": "TAP-RDN-0068",
    "locale": "en",
    "path": "/research/redondo-sanchez-2026/",
    "title": "TAP reading note: Measuring the biological embedding of chronic stress: Allostatic load algorithms and cancer risk in a prospective cohort.",
    "description": "In this nested case-control analysis, clinical-cutoff allostatic load indices had better model fit than the alternative algorithms examined. This supports comparing scoring choices for a specified outcome.",
    "rights": "© The Allostasis Project. All rights reserved. Reproduction or adaptation requires separate permission, subject to applicable legal exceptions.",
    "version": "1.0",
    "updatedAt": "2026-10-30",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-10-30",
      "version": "1.0",
      "byline": "team",
      "author": null,
      "reviewer": null,
      "workflow": {
        "ai": {
          "usage": "used",
          "system": "OpenAI Codex",
          "scope": "Source comparison, evidence extraction, drafting, translation and editing. The materials consulted are stated in each source scope.",
          "version": "1.0",
          "tasks": [
            "Source comparison and evidence extraction",
            "Bilingual drafting, translation and editing"
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        }
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      "revisions": []
    },
    "original": {
      "id": "redondo-sanchez-2026",
      "title": "Measuring the biological embedding of chronic stress: Allostatic load algorithms and cancer risk in a prospective cohort.",
      "authors": "Redondo-Sánchez D, Gálvez-Navas JM, González Flores E, et al.",
      "journal": "Social Science & Medicine",
      "year": "2026",
      "url": "https://doi.org/10.1016/j.socscimed.2026.119840",
      "doi": "10.1016/j.socscimed.2026.119840",
      "pmid": "42801852"
    },
    "references": [
      {
        "id": "redondo-sanchez-2026",
        "title": "Measuring the biological embedding of chronic stress: Allostatic load algorithms and cancer risk in a prospective cohort.",
        "authors": "Redondo-Sánchez D, Gálvez-Navas JM, González Flores E, et al.",
        "journal": "Social Science & Medicine",
        "year": "2026",
        "url": "https://doi.org/10.1016/j.socscimed.2026.119840",
        "doi": "10.1016/j.socscimed.2026.119840",
        "pmid": "42801852"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "What the study found",
        "paragraphs": [
          "In this nested case-control analysis, clinical-cutoff allostatic load indices had better model fit than the alternative algorithms examined. This supports comparing scoring choices for a specified outcome."
        ]
      },
      {
        "id": "limits",
        "title": "Scope & limitations",
        "paragraphs": [
          "955 cancer cases and 955 matched controls in EPIC-Granada.",
          "Observational, outcome-specific evidence; the abstract cannot establish a causal stress pathway or validate a cancer screening tool. Full methods and supplements were not examined."
        ]
      },
      {
        "id": "sample",
        "title": "Population & sample",
        "paragraphs": [
          "1,910 participants: 955 incident cancer cases and 955 matched controls."
        ]
      },
      {
        "id": "exposure",
        "title": "Exposure or intervention",
        "paragraphs": [
          "Sixteen biomarkers scored using four allostatic load algorithms."
        ]
      },
      {
        "id": "outcomes",
        "title": "Outcomes",
        "paragraphs": [
          "Cancer associations and comparison of model fit across algorithms."
        ]
      },
      {
        "id": "duration",
        "title": "Time frame",
        "paragraphs": [
          "Nested analysis of a prospective cohort; the follow-up interval is not established in this abstract-based note."
        ]
      },
      {
        "id": "funding",
        "title": "Research funding",
        "paragraphs": [
          "Funding and competing-interest details have not been verified against the full text. Consult the original publication’s declarations."
        ]
      },
      {
        "id": "conflicts",
        "title": "Research conflicts of interest",
        "paragraphs": [
          "Funding and competing-interest details have not been verified against the full text. Consult the original publication’s declarations."
        ]
      },
      {
        "id": "basis",
        "title": "Reading scope",
        "paragraphs": [
          "Bibliographic record and abstract. Published online on 17 September 2026, assigned to the November 2026 issue."
        ],
        "links": [
          {
            "label": "PubMed",
            "url": "https://pubmed.ncbi.nlm.nih.gov/42801852/"
          }
        ]
      }
    ]
  }
}