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    "kind": "note",
    "key": "quintana-2017",
    "type": "RDN",
    "id": "TAP-RDN-0071",
    "locale": "en",
    "path": "/research/quintana-2017/",
    "title": "TAP reading note: Diurnal Variation and Twenty-Four Hour Sleep Deprivation Do Not Alter Supine Heart Rate Variability in Healthy Male Young Adults.",
    "description": "Supine high-frequency HRV during brain imaging did not show a change attributable to the sleep-deprivation intervention.",
    "rights": "© The Allostasis Project. All rights reserved. Reproduction or adaptation requires separate permission, subject to applicable legal exceptions.",
    "version": "1.0",
    "updatedAt": "2026-10-30",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-10-30",
      "version": "1.0",
      "byline": "team",
      "author": null,
      "reviewer": null,
      "workflow": {
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          "usage": "used",
          "system": "OpenAI Codex",
          "scope": "Source comparison, evidence extraction, drafting, translation and editing. The materials consulted are stated in each source scope.",
          "version": "1.0",
          "tasks": [
            "Source comparison and evidence extraction",
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      "revisions": []
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    "original": {
      "id": "quintana-2017",
      "title": "Diurnal Variation and Twenty-Four Hour Sleep Deprivation Do Not Alter Supine Heart Rate Variability in Healthy Male Young Adults.",
      "authors": "Quintana DS, Elvsåshagen T, Zak N, et al.",
      "journal": "PLOS ONE",
      "year": "2017",
      "url": "https://doi.org/10.1371/journal.pone.0170921",
      "doi": "10.1371/journal.pone.0170921",
      "pmid": "28151944"
    },
    "references": [
      {
        "id": "quintana-2017",
        "title": "Diurnal Variation and Twenty-Four Hour Sleep Deprivation Do Not Alter Supine Heart Rate Variability in Healthy Male Young Adults.",
        "authors": "Quintana DS, Elvsåshagen T, Zak N, et al.",
        "journal": "PLOS ONE",
        "year": "2017",
        "url": "https://doi.org/10.1371/journal.pone.0170921",
        "doi": "10.1371/journal.pone.0170921",
        "pmid": "28151944"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "What the study found",
        "paragraphs": [
          "Supine high-frequency HRV during brain imaging did not show a change attributable to the sleep-deprivation intervention."
        ]
      },
      {
        "id": "limits",
        "title": "Scope & limitations",
        "paragraphs": [
          "40 healthy young men: 20 assigned to sleep deprivation and 20 to normal sleep.",
          "The protocol and metric are specific; a null intervention result does not mean sleep loss is harmless, and supine high-frequency HRV is not wearable overnight RMSSD. Baseline group differences also require care."
        ]
      },
      {
        "id": "sample",
        "title": "Population & sample",
        "paragraphs": [
          "40 healthy men, 20 per randomized condition."
        ]
      },
      {
        "id": "exposure",
        "title": "Exposure or intervention",
        "paragraphs": [
          "Total sleep deprivation versus normal sleep, with repeated supine recordings during an imaging protocol."
        ]
      },
      {
        "id": "outcomes",
        "title": "Outcomes",
        "paragraphs": [
          "High-frequency HRV and its changes across measurement times and conditions."
        ]
      },
      {
        "id": "duration",
        "title": "Time frame",
        "paragraphs": [
          "An acute 24-hour sleep-deprivation protocol."
        ]
      },
      {
        "id": "funding",
        "title": "Research funding",
        "paragraphs": [
          "Novo Nordisk Foundation grant NNF16OC0019856."
        ]
      },
      {
        "id": "conflicts",
        "title": "Research conflicts of interest",
        "paragraphs": [
          "The authors declared no competing interests."
        ]
      },
      {
        "id": "basis",
        "title": "Reading scope",
        "paragraphs": [
          "Full-text methods, results, limitations and funding/interest declarations."
        ],
        "links": [
          {
            "label": "PubMed",
            "url": "https://pubmed.ncbi.nlm.nih.gov/28151944/"
          },
          {
            "label": "Full text (PMC)",
            "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC5289546/"
          }
        ]
      }
    ]
  }
}