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  "capturedAt": "2026-11-13T04:08:26.774Z",
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    "kind": "note",
    "key": "pahor-2014",
    "id": "TAP-RDN-0076",
    "locale": "en",
    "path": "/research/pahor-2014/",
    "title": "TAP reading note: Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial",
    "description": "Structured activity reduced major mobility disability relative to health education: HR 0.82 (95% CI 0.69–0.98). This is evidence about maintaining walking ability in older adults with limitations, not a direct whole-body reserve measurement.",
    "rights": "© The Allostasis Project. All rights reserved. Reproduction or adaptation requires separate permission, subject to applicable legal exceptions.",
    "version": "1.0",
    "updatedAt": "2026-11-13",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-11-13",
      "version": "1.0",
      "byline": "team",
      "author": null,
      "reviewer": null,
      "workflow": {
        "ai": {
          "usage": "used",
          "system": "OpenAI Codex",
          "scope": "Assisted source-based writing and bilingual comparison; consulted materials and unresolved source issues are recorded in the reading notes.",
          "version": "1.0",
          "tasks": [
            "Literature comparison and evidence extraction",
            "Bilingual explanatory writing and source-linked tables"
          ]
        }
      },
      "revisions": []
    },
    "original": {
      "id": "pahor-2014",
      "title": "Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial",
      "authors": "Marco Pahor et al.; LIFE Study Investigators",
      "journal": "JAMA",
      "year": "2014",
      "url": "https://doi.org/10.1001/jama.2014.5616",
      "doi": "10.1001/jama.2014.5616",
      "pmid": "24866862"
    },
    "references": [
      {
        "id": "pahor-2014",
        "title": "Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial",
        "authors": "Marco Pahor et al.; LIFE Study Investigators",
        "journal": "JAMA",
        "year": "2014",
        "url": "https://doi.org/10.1001/jama.2014.5616",
        "doi": "10.1001/jama.2014.5616",
        "pmid": "24866862"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "What the study found",
        "paragraphs": [
          "Structured activity reduced major mobility disability relative to health education: HR 0.82 (95% CI 0.69–0.98). This is evidence about maintaining walking ability in older adults with limitations, not a direct whole-body reserve measurement."
        ]
      },
      {
        "id": "limits",
        "title": "Scope & limitations",
        "paragraphs": [
          "1,635 sedentary adults aged 70–89, with functional limitations but initially able to walk 400 m.",
          "Selected volunteers and a supported programme limit generalisation. Serious adverse events occurred in 49.4% versus 45.7% (RR 1.08, 95% CI 0.98–1.20); nonsignificance does not prove equal safety."
        ]
      },
      {
        "id": "sample",
        "title": "Population & sample",
        "paragraphs": [
          "1,635 sedentary adults aged 70–89, with functional limitations but initially able to walk 400 m."
        ]
      },
      {
        "id": "exposure",
        "title": "Exposure or intervention",
        "paragraphs": [
          "Moderate activity including walking, resistance and flexibility, versus health education and upper-limb stretching."
        ]
      },
      {
        "id": "outcomes",
        "title": "Outcomes",
        "paragraphs": [
          "Loss of ability to walk 400 m; persistent disability and adverse events."
        ]
      },
      {
        "id": "duration",
        "title": "Time frame",
        "paragraphs": [
          "Mean 2.6 years."
        ]
      },
      {
        "id": "funding",
        "title": "Research funding",
        "paragraphs": [
          "NIH/NIA UO1AG22376 (as printed), NHLBI 3U01AG022376-05A2S and intramural support; Pepper Centers 1P30AG028740, 1P30AG21332, 1P30AG031679, P30AG024827, P30AG021342; CTSA UL1RR025744, U54RR025208, UL1TR000142; 1R24HD065688-01A1; K07AG3587 (as printed); VA career-development support; USDA 58-1950-0-014. NIH held one of 12 steering-committee votes."
        ]
      },
      {
        "id": "conflicts",
        "title": "Research conflicts of interest",
        "paragraphs": [
          "Blair: BodyMedia, Coca-Cola and Technogym grants. Fielding: grants, consulting or board relationships involving Dairy Research Institute/Dairy Management, Department of Defense, Nestle, Regeneron, Unilever, Eli Lilly, Essentient, Merck, Aging in Motion, Ammonett, Cytokinetics, Myosyntax and Segterra. McDermott: Informed Medical Decisions Foundation editorship. Sink: Alzheimer’s Association and Donald W. Reynolds Foundation funding and a medical-food trial investigator role. No other disclosures were reported."
        ]
      },
      {
        "id": "basis",
        "title": "Reading scope",
        "paragraphs": [
          "Original published PDF: eligibility, intervention, primary results, adverse-event table and declarations. Supplements and participant-level data were not reanalysed."
        ],
        "links": [
          {
            "label": "Publisher article and supplementary material",
            "url": "https://jamanetwork.com/journals/jama/fullarticle/1875328"
          },
          {
            "label": "PubMed Central full-text record",
            "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4266388/"
          }
        ]
      }
    ]
  }
}