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    "type": "RDN",
    "kind": "note",
    "key": "pahor-2014",
    "id": "TAP-RDN-0076",
    "locale": "zh",
    "path": "/zh/research/pahor-2014/",
    "title": "TAP 导读: Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial",
    "description": "与健康教育相比，结构化身体活动降低了严重移动功能障碍：HR 0.82（95% CI 0.69–0.98）。它支持在功能受限老年人中维持步行能力，并非直接测量全身储备。",
    "rights": "© The Allostasis Project。保留所有权利。除法律允许的例外外，转载或改编需另行授权。",
    "version": "1.0",
    "updatedAt": "2026-11-13",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-11-13",
      "version": "1.0",
      "byline": "team",
      "author": null,
      "reviewer": null,
      "workflow": {
        "ai": {
          "usage": "used",
          "system": "OpenAI Codex",
          "scope": "Assisted source-based writing and bilingual comparison; consulted materials and unresolved source issues are recorded in the reading notes.",
          "version": "1.0",
          "tasks": [
            "Literature comparison and evidence extraction",
            "Bilingual explanatory writing and source-linked tables"
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      "revisions": []
    },
    "original": {
      "id": "pahor-2014",
      "title": "Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial",
      "authors": "Marco Pahor et al.; LIFE Study Investigators",
      "journal": "JAMA",
      "year": "2014",
      "url": "https://doi.org/10.1001/jama.2014.5616",
      "doi": "10.1001/jama.2014.5616",
      "pmid": "24866862"
    },
    "references": [
      {
        "id": "pahor-2014",
        "title": "Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial",
        "authors": "Marco Pahor et al.; LIFE Study Investigators",
        "journal": "JAMA",
        "year": "2014",
        "url": "https://doi.org/10.1001/jama.2014.5616",
        "doi": "10.1001/jama.2014.5616",
        "pmid": "24866862"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "研究发现",
        "paragraphs": [
          "与健康教育相比，结构化身体活动降低了严重移动功能障碍：HR 0.82（95% CI 0.69–0.98）。它支持在功能受限老年人中维持步行能力，并非直接测量全身储备。"
        ]
      },
      {
        "id": "limits",
        "title": "范围与局限",
        "paragraphs": [
          "1,635 名 70–89 岁、久坐、功能受限但起初能步行 400 米的成年人。",
          "受试者为筛选后的志愿者，且活动计划有支持，限制推广。严重不良事件比例为 49.4% 与 45.7%（RR 1.08，95% CI 0.98–1.20）；不显著不代表安全性等同。"
        ]
      },
      {
        "id": "sample",
        "title": "研究人群与样本",
        "paragraphs": [
          "1,635 名 70–89 岁、久坐、功能受限但起初能步行 400 米的成年人。"
        ]
      },
      {
        "id": "exposure",
        "title": "暴露或干预",
        "paragraphs": [
          "包括步行、抗阻和柔韧活动的中等强度计划，对照健康教育和上肢拉伸。"
        ]
      },
      {
        "id": "outcomes",
        "title": "观察结局",
        "paragraphs": [
          "能否完成 400 米步行、持续功能障碍及不良事件。"
        ]
      },
      {
        "id": "duration",
        "title": "时间范围",
        "paragraphs": [
          "平均 2.6 年。"
        ]
      },
      {
        "id": "funding",
        "title": "研究资金来源",
        "paragraphs": [
          "NIH/NIA UO1AG22376（原文写法）、NHLBI 3U01AG022376-05A2S 及内部研究支持；Pepper Centers：1P30AG028740、1P30AG21332、1P30AG031679、P30AG024827、P30AG021342；CTSA：UL1RR025744、U54RR025208、UL1TR000142；1R24HD065688-01A1；K07AG3587（原文写法）；VA 职业发展支持；USDA 58-1950-0-014。NIH 在指导委员会持有十二票中的一票。"
        ]
      },
      {
        "id": "conflicts",
        "title": "研究利益关系",
        "paragraphs": [
          "Blair：BodyMedia、Coca-Cola、Technogym 资助。Fielding：与 Dairy Research Institute/Dairy Management、Department of Defense、Nestle、Regeneron、Unilever、Eli Lilly、Essentient、Merck、Aging in Motion、Ammonett、Cytokinetics、Myosyntax、Segterra 有资助、咨询或董事会关系。McDermott：Informed Medical Decisions Foundation 医学编辑。Sink：Alzheimer’s Association、Donald W. Reynolds Foundation 资助及医用食品试验研究者角色。论文未报告其他披露。"
        ]
      },
      {
        "id": "basis",
        "title": "导读范围",
        "paragraphs": [
          "查阅出版 PDF 中的纳入条件、干预、主要结果、不良事件表及声明；未重新分析补充材料和个体数据。"
        ],
        "links": [
          {
            "label": "出版方正文与补充材料",
            "url": "https://jamanetwork.com/journals/jama/fullarticle/1875328"
          },
          {
            "label": "PubMed Central 全文记录",
            "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4266388/"
          }
        ]
      }
    ]
  }
}