{
  "schemaVersion": 1,
  "capturedAt": "2026-11-13T08:41:22.432Z",
  "sha256": "7a110180bbcfb957c78ef1b0d684f4c089c5db7ceb20a3bed683804e6139bc04",
  "work": {
    "type": "RDN",
    "kind": "note",
    "key": "man-2023",
    "id": "TAP-RDN-0090",
    "locale": "en",
    "path": "/research/man-2023/",
    "title": "TAP reading note: Multi-systemic evaluation of biological and emotional responses to the Trier Social Stress Test: A meta-analysis and systematic review",
    "description": "Cortisol and negative mood were the most sensitive markers in the selected multi-system TSST literature. Sensitivity of other systems was less consistent or based on fewer studies. The result depends on the measure and time contrast.",
    "rights": "© The Allostasis Project. All rights reserved. Reproduction or adaptation requires separate permission, subject to applicable legal exceptions.",
    "version": "1.0",
    "updatedAt": "2026-11-13",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-11-13",
      "version": "1.0",
      "byline": "team",
      "author": null,
      "reviewer": null,
      "workflow": {
        "ai": {
          "usage": "used",
          "system": "OpenAI Codex",
          "scope": "Source-based research, drafting, translation and figure preparation. Access scope is stated in each source note.",
          "version": "1.0",
          "tasks": [
            "Source comparison and quantitative interpretation",
            "Bilingual synthesis and accessible figures"
          ]
        }
      },
      "revisions": []
    },
    "original": {
      "id": "man-2023",
      "title": "Multi-systemic evaluation of biological and emotional responses to the Trier Social Stress Test: A meta-analysis and systematic review",
      "authors": "Man ISC, Shao R, Hou WK, Xin Li S, Liu FY, Lee M, Wing YK, Yau SY, Lee TMC",
      "journal": "Frontiers in neuroendocrinology",
      "year": "2023",
      "url": "https://doi.org/10.1016/j.yfrne.2022.101050",
      "doi": "10.1016/j.yfrne.2022.101050",
      "pmid": "36410619"
    },
    "references": [
      {
        "id": "man-2023",
        "title": "Multi-systemic evaluation of biological and emotional responses to the Trier Social Stress Test: A meta-analysis and systematic review",
        "authors": "Man ISC, Shao R, Hou WK, Xin Li S, Liu FY, Lee M, Wing YK, Yau SY, Lee TMC",
        "journal": "Frontiers in neuroendocrinology",
        "year": "2023",
        "url": "https://doi.org/10.1016/j.yfrne.2022.101050",
        "doi": "10.1016/j.yfrne.2022.101050",
        "pmid": "36410619"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "What the study found",
        "paragraphs": [
          "Cortisol and negative mood were the most sensitive markers in the selected multi-system TSST literature. Sensitivity of other systems was less consistent or based on fewer studies. The result depends on the measure and time contrast."
        ]
      },
      {
        "id": "limits",
        "title": "Scope & limitations",
        "paragraphs": [
          "61 studies in the review; 58 in meta-analyses, with 2,459 healthy participants aged 18–65.",
          "Limited studies for several markers, selected healthy samples and differing time contrasts. Sensitive response markers are not universal personal recovery thresholds."
        ]
      },
      {
        "id": "sample",
        "title": "Population & sample",
        "paragraphs": [
          "61 studies in the review; 58 in meta-analyses, with 2,459 healthy participants aged 18–65."
        ]
      },
      {
        "id": "exposure",
        "title": "Exposure or intervention",
        "paragraphs": [
          "TSST exposure with biological and emotional measurements."
        ]
      },
      {
        "id": "outcomes",
        "title": "Outcomes",
        "paragraphs": [
          "Endocrine, physiological, inflammatory and emotional changes; separate time contrasts."
        ]
      },
      {
        "id": "duration",
        "title": "Time frame",
        "paragraphs": [
          "Included publications spanned 2005–2020; review in the 2023 journal issue."
        ]
      },
      {
        "id": "funding",
        "title": "Research funding",
        "paragraphs": [
          "Hong Kong Research Grants Council Collaborative Research Fund C7079-19GF (T. Lee); Greater Bay Area Centre for Brain Science and Brain-Inspired Intelligence Open Fund 2019007 (R. Shao)."
        ]
      },
      {
        "id": "conflicts",
        "title": "Research conflicts of interest",
        "paragraphs": [
          "The authors declare no competing interests."
        ]
      },
      {
        "id": "basis",
        "title": "Reading scope",
        "paragraphs": [
          "University-repository full text: eligibility, study counts, outcome definitions, results and declarations. Supplementary analyses were not independently reproduced."
        ],
        "links": [
          {
            "label": "PubMed record and abstract",
            "url": "https://pubmed.ncbi.nlm.nih.gov/36410619/"
          },
          {
            "label": "University-hosted full text",
            "url": "https://ira.lib.polyu.edu.hk/bitstream/10397/102286/1/1-s2.0-S0091302222000735-main.pdf"
          }
        ]
      }
    ]
  }
}