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  "capturedAt": "2026-11-13T08:41:22.427Z",
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    "type": "RDN",
    "kind": "note",
    "key": "gideon-2020",
    "id": "TAP-RDN-0093",
    "locale": "en",
    "path": "/research/gideon-2020/",
    "title": "TAP reading note: Kinetics and Interrelations of the Renin Aldosterone Response to Acute Psychosocial Stress: A Neglected Stress System",
    "description": "Table 2 first shows nonsignificant stress-group differences from baseline at 10 minutes for renin, 60 for cortisol, 90 for salivary aldosterone and 180 for plasma aldosterone. Renin later undershot baseline at 30 and 60 minutes.",
    "rights": "© The Allostasis Project. All rights reserved. Reproduction or adaptation requires separate permission, subject to applicable legal exceptions.",
    "version": "1.0",
    "updatedAt": "2026-11-13",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-11-13",
      "version": "1.0",
      "byline": "team",
      "author": null,
      "reviewer": null,
      "workflow": {
        "ai": {
          "usage": "used",
          "system": "OpenAI Codex",
          "scope": "Source-based research, drafting, translation and figure preparation. Access scope is stated in each source note.",
          "version": "1.0",
          "tasks": [
            "Source comparison and quantitative interpretation",
            "Bilingual synthesis and accessible figures"
          ]
        }
      },
      "revisions": []
    },
    "original": {
      "id": "gideon-2020",
      "title": "Kinetics and Interrelations of the Renin Aldosterone Response to Acute Psychosocial Stress: A Neglected Stress System",
      "authors": "Gideon A, Sauter C, Fieres J, Berger T, Renner B, Wirtz PH",
      "journal": "The Journal of clinical endocrinology and metabolism",
      "year": "2020",
      "url": "https://doi.org/10.1210/clinem/dgz190",
      "doi": "10.1210/clinem/dgz190",
      "pmid": "31711229"
    },
    "references": [
      {
        "id": "gideon-2020",
        "title": "Kinetics and Interrelations of the Renin Aldosterone Response to Acute Psychosocial Stress: A Neglected Stress System",
        "authors": "Gideon A, Sauter C, Fieres J, Berger T, Renner B, Wirtz PH",
        "journal": "The Journal of clinical endocrinology and metabolism",
        "year": "2020",
        "url": "https://doi.org/10.1210/clinem/dgz190",
        "doi": "10.1210/clinem/dgz190",
        "pmid": "31711229"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "What the study found",
        "paragraphs": [
          "Table 2 first shows nonsignificant stress-group differences from baseline at 10 minutes for renin, 60 for cortisol, 90 for salivary aldosterone and 180 for plasma aldosterone. Renin later undershot baseline at 30 and 60 minutes."
        ]
      },
      {
        "id": "limits",
        "title": "Scope & limitations",
        "paragraphs": [
          "58 healthy young men randomized to TSST (34) or placebo TSST (24); salivary aldosterone subset 23/15.",
          "Nonsignificance does not establish equivalence, sustained return or recovery in every participant. Discrete samples do not locate exact transition times. Selected hormones and young men cannot represent whole-person recovery."
        ]
      },
      {
        "id": "sample",
        "title": "Population & sample",
        "paragraphs": [
          "58 healthy young men randomized to TSST (34) or placebo TSST (24); salivary aldosterone subset 23/15."
        ]
      },
      {
        "id": "exposure",
        "title": "Exposure or intervention",
        "paragraphs": [
          "Social-evaluative TSST versus a placebo task."
        ]
      },
      {
        "id": "outcomes",
        "title": "Outcomes",
        "paragraphs": [
          "Repeated plasma renin, plasma and salivary aldosterone, and salivary cortisol."
        ]
      },
      {
        "id": "duration",
        "title": "Time frame",
        "paragraphs": [
          "Aldosterone followed for up to 180 minutes; renin and cortisol to 60 minutes after task offset."
        ]
      },
      {
        "id": "funding",
        "title": "Research funding",
        "paragraphs": [
          "DFG EXC 2117–422037984; Swiss National Science Foundation PP00P1_128565/1; German Scholars Organization GSO/CZS 2; Stoll VITA foundation, all to P. H. Wirtz."
        ]
      },
      {
        "id": "conflicts",
        "title": "Research conflicts of interest",
        "paragraphs": [
          "The authors declare no competing interests."
        ]
      },
      {
        "id": "basis",
        "title": "Reading scope",
        "paragraphs": [
          "Published full text: participant groups, sampling schedules, Table 2, results and declarations. Figure 1 reports discrete statistical comparisons; no individual data were reconstructed."
        ],
        "links": [
          {
            "label": "PubMed record and abstract",
            "url": "https://pubmed.ncbi.nlm.nih.gov/31711229/"
          },
          {
            "label": "Published full text",
            "url": "https://d-nb.info/1209879409/34"
          }
        ]
      }
    ]
  }
}