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    "kind": "note",
    "key": "hogenelst-2024",
    "id": "TAP-RDN-0098",
    "locale": "en",
    "path": "/research/hogenelst-2024/",
    "title": "TAP reading note: Seven robust and easy to obtain biomarkers to measure acute stress",
    "description": "Negative affect, heart rate, electrodermal responses and four cytokine measures changed in the same direction on both days. Cortisol AUCi was not significantly different from zero. The results concern sensitivity to acute stress, not whole-system recovery.",
    "rights": "© The Allostasis Project. All rights reserved. Reproduction or adaptation requires separate permission, subject to applicable legal exceptions.",
    "version": "1.0",
    "updatedAt": "2026-11-13",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-11-13",
      "version": "1.0",
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          "system": "OpenAI Codex",
          "scope": "Source-based research, drafting, translation and figure preparation. Access scope is stated in each source note.",
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            "Source comparison and quantitative interpretation",
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      "revisions": []
    },
    "original": {
      "id": "hogenelst-2024",
      "title": "Seven robust and easy to obtain biomarkers to measure acute stress",
      "authors": "Hogenelst K, Özsezen S, Kleemann R, Verschuren L, Stuldreher I, Bottenheft C, van Erp J, Brouwer AM",
      "journal": "Brain, behavior, & immunity - health",
      "year": "2024",
      "url": "https://doi.org/10.1016/j.bbih.2024.100789",
      "doi": "10.1016/j.bbih.2024.100789",
      "pmid": "38799794"
    },
    "references": [
      {
        "id": "hogenelst-2024",
        "title": "Seven robust and easy to obtain biomarkers to measure acute stress",
        "authors": "Hogenelst K, Özsezen S, Kleemann R, Verschuren L, Stuldreher I, Bottenheft C, van Erp J, Brouwer AM",
        "journal": "Brain, behavior, & immunity - health",
        "year": "2024",
        "url": "https://doi.org/10.1016/j.bbih.2024.100789",
        "doi": "10.1016/j.bbih.2024.100789",
        "pmid": "38799794"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "What the study found",
        "paragraphs": [
          "Negative affect, heart rate, electrodermal responses and four cytokine measures changed in the same direction on both days. Cortisol AUCi was not significantly different from zero. The results concern sensitivity to acute stress, not whole-system recovery."
        ]
      },
      {
        "id": "limits",
        "title": "Scope & limitations",
        "paragraphs": [
          "101 participants on day one; 48 tested with another social stressor on day two.",
          "Group-level repeatability does not establish stable individual ranking: only plasma IL-22 showed a significant across-day rank correlation among the seven selected markers. No universal recovery panel was validated."
        ]
      },
      {
        "id": "sample",
        "title": "Population & sample",
        "paragraphs": [
          "101 participants on day one; 48 tested with another social stressor on day two."
        ]
      },
      {
        "id": "exposure",
        "title": "Exposure or intervention",
        "paragraphs": [
          "Standardized acute social stress on two consecutive days."
        ]
      },
      {
        "id": "outcomes",
        "title": "Outcomes",
        "paragraphs": [
          "Affect, autonomic signals, cortisol and plasma/salivary cytokines."
        ]
      },
      {
        "id": "duration",
        "title": "Time frame",
        "paragraphs": [
          "Two-day protocol; repeated pre/post-stressor measurements."
        ]
      },
      {
        "id": "funding",
        "title": "Research funding",
        "paragraphs": [
          "TNO Early Research Program Body–Brain Interaction. Acknowledgements also credit Quanterix staff for help developing salivary cytokine assays."
        ]
      },
      {
        "id": "conflicts",
        "title": "Research conflicts of interest",
        "paragraphs": [
          "The authors declare no competing interests."
        ]
      },
      {
        "id": "basis",
        "title": "Reading scope",
        "paragraphs": [
          "University-hosted full text: methods, Tables 1–2, results on repeated responses, discussion and declarations. Individual data were not reanalysed."
        ],
        "links": [
          {
            "label": "PubMed record and abstract",
            "url": "https://pubmed.ncbi.nlm.nih.gov/38799794/"
          },
          {
            "label": "University-hosted full text",
            "url": "https://ris.utwente.nl/ws/portalfiles/portal/479535869/1-s2.0-S266635462400067X-main.pdf"
          }
        ]
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