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  "work": {
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    "kind": "note",
    "key": "hogenelst-2024",
    "id": "TAP-RDN-0098",
    "locale": "zh",
    "path": "/zh/research/hogenelst-2024/",
    "title": "TAP 导读: Seven robust and easy to obtain biomarkers to measure acute stress",
    "description": "负性情绪、心率、皮电反应及四项细胞因子指标在两天均同方向变化；皮质醇 AUCi 与零的差异不显著。结果涉及急性压力敏感性，不是全系统恢复。",
    "rights": "© The Allostasis Project。保留所有权利。除法律允许的例外外，转载或改编需另行授权。",
    "version": "1.0",
    "updatedAt": "2026-11-13",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-11-13",
      "version": "1.0",
      "byline": "team",
      "author": null,
      "reviewer": null,
      "workflow": {
        "ai": {
          "usage": "used",
          "system": "OpenAI Codex",
          "scope": "基于来源进行研究、写作、翻译和图表整理；各导读分别记录实际查阅范围。",
          "version": "1.0",
          "tasks": [
            "Source comparison and quantitative interpretation",
            "Bilingual synthesis and accessible figures"
          ]
        }
      },
      "revisions": []
    },
    "original": {
      "id": "hogenelst-2024",
      "title": "Seven robust and easy to obtain biomarkers to measure acute stress",
      "authors": "Hogenelst K, Özsezen S, Kleemann R, Verschuren L, Stuldreher I, Bottenheft C, van Erp J, Brouwer AM",
      "journal": "Brain, behavior, & immunity - health",
      "year": "2024",
      "url": "https://doi.org/10.1016/j.bbih.2024.100789",
      "doi": "10.1016/j.bbih.2024.100789",
      "pmid": "38799794"
    },
    "references": [
      {
        "id": "hogenelst-2024",
        "title": "Seven robust and easy to obtain biomarkers to measure acute stress",
        "authors": "Hogenelst K, Özsezen S, Kleemann R, Verschuren L, Stuldreher I, Bottenheft C, van Erp J, Brouwer AM",
        "journal": "Brain, behavior, & immunity - health",
        "year": "2024",
        "url": "https://doi.org/10.1016/j.bbih.2024.100789",
        "doi": "10.1016/j.bbih.2024.100789",
        "pmid": "38799794"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "研究发现",
        "paragraphs": [
          "负性情绪、心率、皮电反应及四项细胞因子指标在两天均同方向变化；皮质醇 AUCi 与零的差异不显著。结果涉及急性压力敏感性，不是全系统恢复。"
        ]
      },
      {
        "id": "limits",
        "title": "范围与局限",
        "paragraphs": [
          "第一天 101 人；48 人第二天接受另一个社会压力任务。",
          "组水平重复出现变化不等于个体排序稳定：七项选定指标中，只有血浆 IL-22 的跨日秩相关显著。研究没有验证通用恢复检测组合。"
        ]
      },
      {
        "id": "sample",
        "title": "研究人群与样本",
        "paragraphs": [
          "第一天 101 人；48 人第二天接受另一个社会压力任务。"
        ]
      },
      {
        "id": "exposure",
        "title": "暴露或干预",
        "paragraphs": [
          "连续两天的标准化急性社会压力任务。"
        ]
      },
      {
        "id": "outcomes",
        "title": "观察结局",
        "paragraphs": [
          "情绪、自主神经信号、皮质醇，以及血浆/唾液细胞因子。"
        ]
      },
      {
        "id": "duration",
        "title": "时间范围",
        "paragraphs": [
          "两天流程，分别进行压力任务前后重复测量。"
        ]
      },
      {
        "id": "funding",
        "title": "研究资金来源",
        "paragraphs": [
          "TNO Early Research Program Body–Brain Interaction 资助；致谢同时注明 Quanterix 工作人员协助开发唾液细胞因子检测方法。"
        ]
      },
      {
        "id": "conflicts",
        "title": "研究利益关系",
        "paragraphs": [
          "作者声明没有利益冲突。"
        ]
      },
      {
        "id": "basis",
        "title": "导读范围",
        "paragraphs": [
          "查阅大学托管全文的方法、表 1—2、重复反应结果、讨论和声明；未重新分析个体数据。"
        ],
        "links": [
          {
            "label": "PubMed 书目与摘要",
            "url": "https://pubmed.ncbi.nlm.nih.gov/38799794/"
          },
          {
            "label": "大学托管全文",
            "url": "https://ris.utwente.nl/ws/portalfiles/portal/479535869/1-s2.0-S266635462400067X-main.pdf"
          }
        ]
      }
    ]
  }
}