{
  "schemaVersion": 1,
  "capturedAt": "2026-11-13T08:41:22.422Z",
  "sha256": "013df0ae5c5fc59f2c209384686729d52b2a9318b6b0b99ea87a3b6ff8cd5b6a",
  "work": {
    "type": "RDN",
    "kind": "note",
    "key": "steptoe-2016",
    "id": "TAP-RDN-0100",
    "locale": "en",
    "path": "/research/steptoe-2016/",
    "title": "TAP reading note: Blood Pressure and Fibrinogen Responses to Mental Stress as Predictors of Incident Hypertension over an 8-Year Period",
    "description": "Highest versus lowest recovery-period systolic pressure tertile was associated with incident hypertension: adjusted OR 2.06 (95% CI 1.19–3.57). This is a specific prospective association, not a personal recovery cutoff.",
    "rights": "© The Allostasis Project. All rights reserved. Reproduction or adaptation requires separate permission, subject to applicable legal exceptions.",
    "version": "1.0",
    "updatedAt": "2026-11-13",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-11-13",
      "version": "1.0",
      "byline": "team",
      "author": null,
      "reviewer": null,
      "workflow": {
        "ai": {
          "usage": "used",
          "system": "OpenAI Codex",
          "scope": "Source-based research, drafting, translation and figure preparation. Access scope is stated in each source note.",
          "version": "1.0",
          "tasks": [
            "Source comparison and quantitative interpretation",
            "Bilingual synthesis and accessible figures"
          ]
        }
      },
      "revisions": []
    },
    "original": {
      "id": "steptoe-2016",
      "title": "Blood Pressure and Fibrinogen Responses to Mental Stress as Predictors of Incident Hypertension over an 8-Year Period",
      "authors": "Steptoe A, Kivimäki M, Lowe G, Rumley A, Hamer M",
      "journal": "Annals of behavioral medicine : a publication of the Society of Behavioral Medicine",
      "year": "2016",
      "url": "https://doi.org/10.1007/s12160-016-9817-5",
      "doi": "10.1007/s12160-016-9817-5",
      "pmid": "27401000"
    },
    "references": [
      {
        "id": "steptoe-2016",
        "title": "Blood Pressure and Fibrinogen Responses to Mental Stress as Predictors of Incident Hypertension over an 8-Year Period",
        "authors": "Steptoe A, Kivimäki M, Lowe G, Rumley A, Hamer M",
        "journal": "Annals of behavioral medicine : a publication of the Society of Behavioral Medicine",
        "year": "2016",
        "url": "https://doi.org/10.1007/s12160-016-9817-5",
        "doi": "10.1007/s12160-016-9817-5",
        "pmid": "27401000"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "What the study found",
        "paragraphs": [
          "Highest versus lowest recovery-period systolic pressure tertile was associated with incident hypertension: adjusted OR 2.06 (95% CI 1.19–3.57). This is a specific prospective association, not a personal recovery cutoff."
        ]
      },
      {
        "id": "limits",
        "title": "Scope & limitations",
        "paragraphs": [
          "636 Whitehall II participants without hypertension or cardiovascular disease at baseline; mean age 59.1.",
          "Non-randomized exposure, residual confounding and a selected cohort limit causal interpretation. OR is not a direct ratio of individual probabilities. Baseline pressure was included among adjustments."
        ]
      },
      {
        "id": "sample",
        "title": "Population & sample",
        "paragraphs": [
          "636 Whitehall II participants without hypertension or cardiovascular disease at baseline; mean age 59.1."
        ]
      },
      {
        "id": "exposure",
        "title": "Exposure or intervention",
        "paragraphs": [
          "Blood-pressure and fibrinogen responses to standardized mental tasks."
        ]
      },
      {
        "id": "outcomes",
        "title": "Outcomes",
        "paragraphs": [
          "Incident hypertension defined by clinic readings and medication status."
        ]
      },
      {
        "id": "duration",
        "title": "Time frame",
        "paragraphs": [
          "Average eight-year follow-up."
        ]
      },
      {
        "id": "funding",
        "title": "Research funding",
        "paragraphs": [
          "British Heart Foundation RG/10/005/28296, as indexed in the publication declaration."
        ]
      },
      {
        "id": "conflicts",
        "title": "Research conflicts of interest",
        "paragraphs": [
          "Not yet verified against the full text."
        ]
      },
      {
        "id": "basis",
        "title": "Reading scope",
        "paragraphs": [
          "UCL-hosted published full text: sample, Table 3, recovery-tertile comparison and funding statement. No individual-risk model was reproduced."
        ],
        "links": [
          {
            "label": "PubMed record and abstract",
            "url": "https://pubmed.ncbi.nlm.nih.gov/27401000/"
          },
          {
            "label": "UCL-hosted published full text",
            "url": "https://discovery.ucl.ac.uk/id/eprint/1504197/1/art%253A10.1007%252Fs12160-016-9817-5.pdf"
          }
        ]
      }
    ]
  }
}