{
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  "capturedAt": "2026-11-13T08:41:22.414Z",
  "sha256": "0fb26ddb5b7ab82beb7bb4ea93cbe872907b4f5c8c3d81f6d37a1f0ce2c167dd",
  "work": {
    "type": "RDN",
    "kind": "note",
    "key": "pruessner-2003",
    "id": "TAP-RDN-0101",
    "locale": "en",
    "path": "/research/pruessner-2003/",
    "title": "TAP reading note: Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change",
    "description": "Distinguishes area under the curve relative to ground (AUCg) from area relative to the initial value (AUCi). Overall concentration over time and change from baseline can show different associations.",
    "rights": "© The Allostasis Project. All rights reserved. Reproduction or adaptation requires separate permission, subject to applicable legal exceptions.",
    "version": "1.0",
    "updatedAt": "2026-11-13",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-11-13",
      "version": "1.0",
      "byline": "team",
      "author": null,
      "reviewer": null,
      "workflow": {
        "ai": {
          "usage": "used",
          "system": "OpenAI Codex",
          "scope": "Source-based research, drafting, translation and figure preparation. Access scope is stated in each source note.",
          "version": "1.0",
          "tasks": [
            "Source comparison and quantitative interpretation",
            "Bilingual synthesis and accessible figures"
          ]
        }
      },
      "revisions": []
    },
    "original": {
      "id": "pruessner-2003",
      "title": "Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change",
      "authors": "Pruessner JC, Kirschbaum C, Meinlschmid G, Hellhammer DH",
      "journal": "Psychoneuroendocrinology",
      "year": "2003",
      "url": "https://doi.org/10.1016/S0306-4530(02)00108-7",
      "doi": "10.1016/S0306-4530(02)00108-7",
      "pmid": "12892658"
    },
    "references": [
      {
        "id": "pruessner-2003",
        "title": "Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change",
        "authors": "Pruessner JC, Kirschbaum C, Meinlschmid G, Hellhammer DH",
        "journal": "Psychoneuroendocrinology",
        "year": "2003",
        "url": "https://doi.org/10.1016/S0306-4530(02)00108-7",
        "doi": "10.1016/S0306-4530(02)00108-7",
        "pmid": "12892658"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "What the study found",
        "paragraphs": [
          "Distinguishes area under the curve relative to ground (AUCg) from area relative to the initial value (AUCi). Overall concentration over time and change from baseline can show different associations."
        ]
      },
      {
        "id": "limits",
        "title": "Scope & limitations",
        "paragraphs": [
          "Methodological examples using artificial and human hormone data.",
          "Neither summary automatically estimates recovery duration. Formula, baseline and observation window must be stated. A linked 2004 letter and reply are commentary, not automatically an erratum."
        ]
      },
      {
        "id": "sample",
        "title": "Population & sample",
        "paragraphs": [
          "Methodological examples using artificial and human hormone data."
        ]
      },
      {
        "id": "exposure",
        "title": "Exposure or intervention",
        "paragraphs": [
          "Repeated hormone concentration measurements summarized with trapezoidal formulas."
        ]
      },
      {
        "id": "outcomes",
        "title": "Outcomes",
        "paragraphs": [
          "AUCg and AUCi and their interpretation."
        ]
      },
      {
        "id": "duration",
        "title": "Time frame",
        "paragraphs": [
          "Depends on the time series supplied; no universal sampling interval."
        ]
      },
      {
        "id": "funding",
        "title": "Research funding",
        "paragraphs": [
          "Not yet verified against the full text."
        ]
      },
      {
        "id": "conflicts",
        "title": "Research conflicts of interest",
        "paragraphs": [
          "Not yet verified against the full text."
        ]
      },
      {
        "id": "basis",
        "title": "Reading scope",
        "paragraphs": [
          "PubMed original abstract and bibliographic record; linked letter/reply record checked, but its text was not available for assessment. No new AUC calculations were performed."
        ],
        "links": [
          {
            "label": "PubMed record and abstract",
            "url": "https://pubmed.ncbi.nlm.nih.gov/12892658/"
          },
          {
            "label": "2004 letter and author-reply record",
            "url": "https://pubmed.ncbi.nlm.nih.gov/14749099/"
          }
        ]
      }
    ]
  }
}