{
  "schemaVersion": 1,
  "capturedAt": "2026-11-13T08:41:22.481Z",
  "sha256": "d2893199201579223eae38324dc999ae379ac2df5ff65e45c8ee9ae66673ed1e",
  "work": {
    "type": "RDN",
    "kind": "note",
    "key": "pruessner-2003",
    "id": "TAP-RDN-0101",
    "locale": "zh",
    "path": "/zh/research/pruessner-2003/",
    "title": "TAP 导读: Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change",
    "description": "区分相对于零水平的曲线下面积 AUCg，与相对于初始值的曲线下面积 AUCi。随时间的整体浓度和相对基线变化，可能呈现不同关联。",
    "rights": "© The Allostasis Project。保留所有权利。除法律允许的例外外，转载或改编需另行授权。",
    "version": "1.0",
    "updatedAt": "2026-11-13",
    "editorial": {
      "contentType": "evidence-review",
      "reviewState": "draft",
      "reviewedAt": null,
      "reviewedVersion": null,
      "updatedAt": "2026-11-13",
      "version": "1.0",
      "byline": "team",
      "author": null,
      "reviewer": null,
      "workflow": {
        "ai": {
          "usage": "used",
          "system": "OpenAI Codex",
          "scope": "基于来源进行研究、写作、翻译和图表整理；各导读分别记录实际查阅范围。",
          "version": "1.0",
          "tasks": [
            "Source comparison and quantitative interpretation",
            "Bilingual synthesis and accessible figures"
          ]
        }
      },
      "revisions": []
    },
    "original": {
      "id": "pruessner-2003",
      "title": "Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change",
      "authors": "Pruessner JC, Kirschbaum C, Meinlschmid G, Hellhammer DH",
      "journal": "Psychoneuroendocrinology",
      "year": "2003",
      "url": "https://doi.org/10.1016/S0306-4530(02)00108-7",
      "doi": "10.1016/S0306-4530(02)00108-7",
      "pmid": "12892658"
    },
    "references": [
      {
        "id": "pruessner-2003",
        "title": "Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change",
        "authors": "Pruessner JC, Kirschbaum C, Meinlschmid G, Hellhammer DH",
        "journal": "Psychoneuroendocrinology",
        "year": "2003",
        "url": "https://doi.org/10.1016/S0306-4530(02)00108-7",
        "doi": "10.1016/S0306-4530(02)00108-7",
        "pmid": "12892658"
      }
    ],
    "sections": [
      {
        "id": "finding",
        "title": "研究发现",
        "paragraphs": [
          "区分相对于零水平的曲线下面积 AUCg，与相对于初始值的曲线下面积 AUCi。随时间的整体浓度和相对基线变化，可能呈现不同关联。"
        ]
      },
      {
        "id": "limits",
        "title": "范围与局限",
        "paragraphs": [
          "利用人工示例与人体激素数据的方法说明。",
          "两种汇总都不自动估计恢复时长；需要说明公式、基线和观察窗口。2004 年关联来信及回复属于学术评论，不能自动视为勘误。"
        ]
      },
      {
        "id": "sample",
        "title": "研究人群与样本",
        "paragraphs": [
          "利用人工示例与人体激素数据的方法说明。"
        ]
      },
      {
        "id": "exposure",
        "title": "暴露或干预",
        "paragraphs": [
          "用梯形公式汇总重复激素浓度测量。"
        ]
      },
      {
        "id": "outcomes",
        "title": "观察结局",
        "paragraphs": [
          "AUCg、AUCi 及其解释。"
        ]
      },
      {
        "id": "duration",
        "title": "时间范围",
        "paragraphs": [
          "取决于输入的时间序列；没有普遍采样间隔。"
        ]
      },
      {
        "id": "funding",
        "title": "研究资金来源",
        "paragraphs": [
          "尚未根据全文核实。"
        ]
      },
      {
        "id": "conflicts",
        "title": "研究利益关系",
        "paragraphs": [
          "尚未根据全文核实。"
        ]
      },
      {
        "id": "basis",
        "title": "导读范围",
        "paragraphs": [
          "查阅原文 PubMed 摘要及书目，并核对关联来信/回复记录；未获得后者正文用于评估。没有进行新的 AUC 计算。"
        ],
        "links": [
          {
            "label": "PubMed 书目与摘要",
            "url": "https://pubmed.ncbi.nlm.nih.gov/12892658/"
          },
          {
            "label": "2004 年来信与作者回复记录",
            "url": "https://pubmed.ncbi.nlm.nih.gov/14749099/"
          }
        ]
      }
    ]
  }
}