TAP reading note: Allostatic Load and Mortality: A Systematic Review and Meta-Analysis

What the study found

Higher allostatic load was associated with higher all-cause and cardiovascular mortality in pooled observational evidence. The size of the association varied substantially between studies.

Scope & limitations

Systematic review of 17 eligible studies. Main pooled estimates used 10 studies for all-cause mortality and six for cardiovascular mortality.

Most pooled estimates had very high heterogeneity (I² above 90%). The associations do not quantify an individual lifespan or the benefit of an intervention that changes an AL score.

Population & sample

Systematic review of 17 eligible studies. Main pooled estimates used 10 studies for all-cause mortality and six for cardiovascular mortality.

Exposure or intervention

Higher versus lower allostatic load, as defined separately by each study.

Outcomes

All-cause and cardiovascular mortality; these outcomes were synthesized separately.

Time frame

Database searches in May 2021; eligible studies published from 2001 to 2020.

Research funding

Not yet checked against the full publication.

Research conflicts of interest

Not yet checked against the full publication.

Reading scope

Based on the original publication’s abstract and bibliographic record. This is a selected reading note, not a systematic appraisal.

References

1. Haley W. Parker, Alyssa M. Abreu, Mary C. Sullivan, Maya K. Vadiveloo (2022). Allostatic Load and Mortality: A Systematic Review and Meta-Analysis. American Journal of Preventive Medicine. https://doi.org/10.1016/j.amepre.2022.02.003

Publication record

TAP-RDN-0015 · v0.1 · English

Scientific review has not been completed for this edition.

The Allostasis Project is founded and supported by Resilio.

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