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TAP 导读: Allostatic Load and Mortality: A Systematic Review and Meta-Analysis

汇总的观察性证据显示,较高适应负荷与较高全因死亡及心血管死亡风险相关,但研究之间的关联大小存在明显差异。

更新于 2026-09-14 · 存档于

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研究发现

汇总的观察性证据显示,较高适应负荷与较高全因死亡及心血管死亡风险相关,但研究之间的关联大小存在明显差异。

范围与局限

系统综述纳入 17 项研究;主要合并估计中,全因死亡使用 10 项研究,心血管死亡使用 6 项研究。

多数合并估计的异质性很高,I² 超过 90%。这些关联不能用于计算个人寿命,也不能估计某项降低 AL 分数的干预会带来多少收益。

研究人群与样本

系统综述纳入 17 项研究;主要合并估计中,全因死亡使用 10 项研究,心血管死亡使用 6 项研究。

暴露或干预

各研究分别定义的较高与较低适应负荷。

观察结局

全因死亡和心血管死亡,分别进行证据合并。

时间范围

2021 年 5 月检索数据库;纳入研究发表于 2001–2020 年。

研究资金来源

尚未根据完整论文核查。

研究利益关系

尚未根据完整论文核查。

导读范围

依据原论文摘要与书目记录撰写的精选导读,未进行系统证据评价。

参考文献

  1. Haley W. Parker, Alyssa M. Abreu, Mary C. Sullivan, Maya K. Vadiveloo (2022). Allostatic Load and Mortality: A Systematic Review and Meta-Analysis. American Journal of Preventive Medicine. https://doi.org/10.1016/j.amepre.2022.02.003

出版记录

TAP-RDN-0015 · v0.1 · 中文

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存档时间: 2026-09-14T11:37:40.862Z

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