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Towards a consensus definition of allostatic load: a multi-cohort, multi-system, multi-biomarker individual participant data (IPD) meta-analysis

Cathal McCrory · Sinead McLoughlin · Richard Layte · Cliona NiCheallaigh · Aisling M. O’Halloran · Henrique Barros · Lisa F. Berkman · Murielle Bochud · Eileen M. Crimmins · Meagan T. Farrell · Silvia Fraga · Emily Grundy · Michelle Kelly-Irving · Dusan Petrovic · Teresa Seeman · Silvia Stringhini · Peter Vollenveider · Rose Anne Kenny
Psychoneuroendocrinology · 2023

查看原始来源 DOI: 10.1016/j.psyneuen.2023.106117 ↗PubMed: 37100008 ↗

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这篇研究说了什么

这项跨队列分析尝试缩小适应负荷指标的选择范围。CRP、静息心率、HDL胆固醇、腰高比和HbA1c组成的五项组合，在研究内的死亡预测表现与更长组合相近；加入呼气峰流量还可能提供额外信息。它提出了协调测量的候选指标集。

适用范围与解释

队列按资料可得性选择；健康结局多为横断面，死亡随访长短不同。按健康结局筛选指标，并未证明它们对心理压力特异，也未给出可直接用于个人诊断的统一截点。年轻人群、性别差异、用药影响和外部校准仍需研究。

研究概览

研究人群与样本
13个队列、67,126名40—111岁参与者；死亡资料来自其中10个队列。
暴露、干预或研究对象
比较12个生理系统的40项标志物及不同长度的组合；采用两阶段个体参与者数据荟萃分析。
观察结局
健康功能指标及死亡；死亡资料按二分类结局分析，未统一为相同随访长度的生存模型。
时间范围
死亡随访因队列而异，约2—14年；其他主要健康指标为横断面。

本站引用位置

基础概念

适应负荷

科学专题

适应负荷如何测量？看懂生物标志物、计分方法与局限

同样的生物标志物，为什么会得到不同分数？
编辑与审阅记录

对应版本 v0.3 · 更新于

编辑责任: TAP Editorial Team

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本文由 TAP Editorial Team 承担编辑责任，使用 AI 辅助内容整理与编辑。

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了解责任分工与审阅标准 ↗

导读范围

依据作者版全文的研究人群、统计方法、五项指标比较及建议部分；附表S5/S6、外部校准与全部队列附件尚待核读。

研究资金来源
包括爱尔兰Health Research Board EIA-2017-012、英国ESRC ES/T014083/1及ERC Gendhi项目等；各队列另有资助，部分涉及商业支持，完整清单见原文。
研究利益关系
独立利益声明及各队列全部披露尚未核全。

项目支持

由 Resilio 发起并支持。

内容修订记录

  1. · v0.3

    补充13队列的指标选择、死亡分析口径及五项组合的适用边界。

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项目信息隐私政策项目信息联系我们评估工具TAP 负荷与恢复评估方法负荷与恢复评估：方法与开发探索频道关于人体适应的科学问题探索频道测量与解释阅读指南 · 精选 35 篇负荷与恢复：六条研究线索阅读指南 · 精选 5 篇适应负荷阅读指南 · 精选 5 篇恢复科学阅读指南 · 精选 5 篇储备与复原力阅读指南 · 精选 5 篇测量与解释基础概念负荷Load基础概念动态适应Allostasis基础概念恢复Recovery基础概念适应负荷Allostatic Load基础概念生理储备Physiological Reserve基础概念复原力Resilience科学专题适应负荷如何测量？看懂生物标志物、计分方法与局限科学专题恢复，不只是休息科学专题什么是复原力营养？科学专题适应模型：不同框架分别解释什么？科学专题TAP 人体动态适应框架科学专题HRV 能告诉我们多少关于恢复的信息？科学专题HRV为什么会下降？把低读数放回测量、生活与恢复背景中科学专题为什么下班了，身体还没有“下班”？科学专题吃得不够，会影响恢复吗？科学专题周末补觉，能补回一周的睡眠不足吗？科学专题恢复一定意味着回到原来的基线吗？科学专题恢复与复原力是一回事吗？科学专题感觉好一些，为什么不一定代表已经恢复？科学专题手表上的恢复分数，到底在告诉你什么？科学专题生理储备与复原力是什么关系？科学专题营养如何影响恢复？从人体研究看机制、功能与适用边界方法与项目证据分级与评价方法方法与项目编辑与科学标准方法与项目关于项目研究文献 · 1988Muscle glycogen synthesis after exercise: effect of time of carbohydrate ingestion.研究文献 · 1993Stress and the individual. 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