EN
探索科学计划
研究库 / 2023 / 荟萃分析

Towards a consensus definition of allostatic load: a multi-cohort, multi-system, multi-biomarker individual participant data (IPD) meta-analysis

Cathal McCrory · Sinead McLoughlin · Richard Layte · Cliona NiCheallaigh · Aisling M. O’Halloran · Henrique Barros · Lisa F. Berkman · Murielle Bochud · Eileen M. Crimmins · Meagan T. Farrell · Silvia Fraga · Emily Grundy · Michelle Kelly-Irving · Dusan Petrovic · Teresa Seeman · Silvia Stringhini · Peter Vollenveider · Rose Anne Kenny
Psychoneuroendocrinology · 2023

查看原始来源 DOI: 10.1016/j.psyneuen.2023.106117 ↗PubMed: 37100008 ↗

编辑责任TAP Editorial Team

编辑与审阅记录 ↗
转载说明 ↗
THE ALLOSTASIS PROJECT

引用这份作品

原论文 · 引用研究结果时使用此来源。

下载引用文件:BibTeXRISCSL-JSONTXT

这篇研究说了什么

作者在 13 个队列中比较了生物指标与功能、自评健康的关联。报告的分析中，一个五指标组合对死亡结局的预测表现，与更复杂的组合相当或更好。

读到这里，需要注意

这为所研究队列中的测量协调提供依据，并未建立通用诊断阈值，也不能证明所有指标差异均由压力造成，或降低分数就能改善健康。

研究概览

研究人群与样本
个体参与者数据分析：67,126 名 40–111 岁参与者；比较涉及 12 个生理系统的 40 项候选指标。
暴露、干预或研究对象
用于操作化适应负荷的不同生物指标组合。
观察结局
握力、步行速度、自评健康；另以死亡作为结局考察预测表现。
时间范围
多个队列的观察期不同；论文发表于 2023 年。

本站引用位置

基础概念

适应负荷

科学专题

适应负荷：适应的隐性成本

编辑与审阅记录

对应版本 v0.1 · 更新于

  1. 编辑与校对

    暂无完成记录

  2. 来源与数字核验

    暂无完成记录

  3. 科学审阅

    尚未完成科学审阅

  4. 方法学审阅

    暂无完成记录

  5. AI 辅助

    使用情况尚未记录
了解责任分工与审阅标准 ↗

导读范围

依据原论文摘要与书目记录撰写的精选导读，未进行系统证据评价。

研究资金来源
尚未根据完整论文核查。
研究利益关系
尚未根据完整论文核查。

项目支持

由 Resilio 发起并支持。

阅读编辑标准 ↗

从一个问题开始。

输入关键词，搜索本站内容。

探索频道关于人体适应的科学问题探索频道测量与解释阅读指南 · 精选 5 篇适应负荷阅读指南 · 精选 5 篇恢复科学阅读指南 · 精选 5 篇储备与复原力阅读指南 · 精选 5 篇测量与解释基础概念负荷Load基础概念动态适应Allostasis基础概念恢复Recovery基础概念适应负荷Allostatic Load基础概念生理储备Physiological Reserve基础概念复原力Resilience科学专题适应负荷：适应的隐性成本科学专题恢复，不只是休息科学专题适应模型：不同框架分别解释什么？科学专题TAP 人体动态适应框架科学专题HRV 能告诉我们多少关于恢复的信息？科学专题恢复一定意味着回到原来的基线吗？科学专题恢复与复原力是一回事吗？科学专题感觉好一些，为什么不一定代表已经恢复？科学专题生理储备与复原力是什么关系？方法与项目证据分级与评价方法方法与项目编辑与科学标准方法与项目关于项目研究文献 · 1993Stress and the individual. Mechanisms leading to disease研究文献 · 1998Protective and damaging effects of stress mediators研究文献 · 2003The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation研究文献 · 2006The perseverative cognition hypothesis: a review of worry, prolonged stress-related physiological activation, and health研究文献 · 2007The Recovery Experience Questionnaire: development and validation of a measure for assessing recuperation and unwinding from work研究文献 · 2009The Reactive Scope Model — A new model integrating homeostasis, allostasis, and stress研究文献 · 2010Neurobehavioral dynamics following chronic sleep restriction: dose-response effects of one night for recovery研究文献 · 2010Greater cardiovascular responses to laboratory mental stress are associated with poor subsequent cardiovascular risk status: a meta-analysis of prospective evidence研究文献 · 2010Allostatic load biomarkers of chronic stress and impact on health and cognition研究文献 · 2011Stress- and Allostasis-Induced Brain Plasticity研究文献 · 2012Allostasis: a model of predictive regulation研究文献 · 2013The LF/HF ratio does not accurately measure cardiac sympatho-vagal balance研究文献 · 2013Effects of recovery sleep after one work week of mild sleep restriction on interleukin-6 and cortisol secretion and daytime sleepiness and performance研究文献 · 2014Clarifying the roles of homeostasis and allostasis in physiological regulation研究文献 · 2014Resilience definitions, theory, and challenges: interdisciplinary perspectives研究文献 · 2015Recovery from job stress: The stressor-detachment model as an integrative framework研究文献 · 2016Physiological concomitants of perseverative cognition: A systematic review and meta-analysis研究文献 · 2016Physical Resilience in Older Adults: Systematic Review and Development of an Emerging Construct研究文献 · 2017Heart Rate Variability and Cardiac Vagal Tone in Psychophysiological Research - Recommendations for Experiment Planning, Data Analysis, and Data Reporting研究文献 · 2017A Meta-Analysis on Antecedents and Outcomes of Detachment from Work研究文献 · 2018Recovery and Performance in Sport: Consensus Statement研究文献 · 2019Ad libitum Weekend Recovery Sleep Fails to Prevent Metabolic Dysregulation during a Repeating Pattern of Insufficient Sleep and Weekend Recovery Sleep研究文献 · 2019Resilience in Clinical Care: Getting a Grip on the Recovery Potential of Older Adults研究文献 · 2020Whitepaper: Defining and investigating cognitive reserve, brain reserve, and brain maintenance研究文献 · 2021Leaving Work at Work: A Meta-Analysis on Employee Recovery From Work研究文献 · 2022"Give me a break!" A systematic review and meta-analysis on the efficacy of micro-breaks for increasing well-being and performance研究文献 · 2022Allostatic Load Measurement: A Systematic Review of Reviews, Database Inventory, and Considerations for Neighborhood Research研究文献 · 2022Allostatic Load and Mortality: A Systematic Review and Meta-Analysis研究文献 · 2022Recovery from Work: Advancing the Field Toward the Future研究文献 · 2023Conceptualizing a resilience research framework at The National Institutes of Health研究文献 · 2023Towards a consensus definition of allostatic load: a multi-cohort, multi-system, multi-biomarker individual participant data (IPD) meta-analysis研究文献 · 2024Impact of baseline and longitudinal allostatic load changes on incident cardiovascular disease and all-cause mortality: A 7-year population-based cohort study in China研究文献 · 2025Resilience phenotypes derived from an active inference account of allostasis研究文献 · 2026Building an ontology of resilience: Insights from the physical resilience literatureTAP Record · TAP-CON-0001负荷TAP Record · TAP-CON-0002动态适应TAP Record · TAP-CON-0003恢复TAP Record · TAP-CON-0004适应负荷TAP Record · TAP-CON-0005生理储备TAP Record · TAP-CON-0006复原力TAP Record · TAP-FTR-0001适应负荷：适应的隐性成本TAP Record · TAP-FTR-0002恢复，不只是休息TAP Record · TAP-FTR-0008适应模型：不同框架分别解释什么？TAP Record · TAP-MDL-0001TAP 人体动态适应框架TAP Record · TAP-FTR-0005HRV 能告诉我们多少关于恢复的信息？TAP Record · TAP-FTR-0007恢复一定意味着回到原来的基线吗？TAP Record · TAP-FTR-0006恢复与复原力是一回事吗？TAP Record · TAP-FTR-0003感觉好一些，为什么不一定代表已经恢复？TAP Record · TAP-FTR-0004生理储备与复原力是什么关系？TAP Record · TAP-RDN-0001TAP 导读: Stress and the individual. Mechanisms leading to diseaseTAP Record · TAP-RDN-0002TAP 导读: Protective and damaging effects of stress mediatorsTAP Record · TAP-RDN-0003TAP 导读: The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivationTAP Record · TAP-RDN-0016TAP 导读: The perseverative cognition hypothesis: a review of worry, prolonged stress-related physiological activation, and healthTAP Record · TAP-RDN-0020TAP 导读: The Recovery Experience Questionnaire: development and validation of a measure for assessing recuperation and unwinding from workTAP Record · TAP-RDN-0032TAP 导读: The Reactive Scope Model — A new model integrating homeostasis, allostasis, and stressTAP Record · TAP-RDN-0024TAP 导读: Neurobehavioral dynamics following chronic sleep restriction: dose-response effects of one night for recoveryTAP Record · TAP-RDN-0004TAP 导读: Greater cardiovascular responses to laboratory mental stress are associated with poor subsequent cardiovascular risk status: a meta-analysis of prospective evidenceTAP Record · TAP-RDN-0013TAP 导读: Allostatic load biomarkers of chronic stress and impact on health and cognitionTAP Record · TAP-RDN-0005TAP 导读: Stress- and Allostasis-Induced Brain PlasticityTAP Record · TAP-RDN-0006TAP 导读: Allostasis: a model of predictive regulationTAP Record · TAP-RDN-0018TAP 导读: The LF/HF ratio does not accurately measure cardiac sympatho-vagal balanceTAP Record · TAP-RDN-0026TAP 导读: Effects of recovery sleep after one work week of mild sleep restriction on interleukin-6 and cortisol secretion and daytime sleepiness and performanceTAP Record · TAP-RDN-0012TAP 导读: Clarifying the roles of homeostasis and allostasis in physiological regulationTAP Record · TAP-RDN-0029TAP 导读: Resilience definitions, theory, and challenges: interdisciplinary perspectivesTAP Record · TAP-RDN-0007TAP 导读: Recovery from job stress: The stressor-detachment model as an integrative frameworkTAP Record · TAP-RDN-0017TAP 导读: Physiological concomitants of perseverative cognition: A systematic review and meta-analysisTAP Record · TAP-RDN-0008TAP 导读: Physical Resilience in Older Adults: Systematic Review and Development of an Emerging ConstructTAP Record · TAP-RDN-0019TAP 导读: Heart Rate Variability and Cardiac Vagal Tone in Psychophysiological Research - Recommendations for Experiment Planning, Data Analysis, and Data ReportingTAP Record · TAP-RDN-0009TAP 导读: A Meta-Analysis on Antecedents and Outcomes of Detachment from WorkTAP Record · TAP-RDN-0010TAP 导读: Recovery and Performance in Sport: Consensus StatementTAP Record · TAP-RDN-0025TAP 导读: Ad libitum Weekend Recovery Sleep Fails to Prevent Metabolic Dysregulation during a Repeating Pattern of Insufficient Sleep and Weekend Recovery SleepTAP Record · TAP-RDN-0027TAP 导读: Resilience in Clinical Care: Getting a Grip on the Recovery Potential of Older AdultsTAP Record · TAP-RDN-0028TAP 导读: Whitepaper: Defining and investigating cognitive reserve, brain reserve, and brain maintenanceTAP Record · TAP-RDN-0022TAP 导读: Leaving Work at Work: A Meta-Analysis on Employee Recovery From WorkTAP Record · TAP-RDN-0023TAP 导读: "Give me a break!" A systematic review and meta-analysis on the efficacy of micro-breaks for increasing well-being and performanceTAP Record · TAP-RDN-0011TAP 导读: Allostatic Load Measurement: A Systematic Review of Reviews, Database Inventory, and Considerations for Neighborhood ResearchTAP Record · TAP-RDN-0015TAP 导读: Allostatic Load and Mortality: A Systematic Review and Meta-AnalysisTAP Record · TAP-RDN-0021TAP 导读: Recovery from Work: Advancing the Field Toward the FutureTAP Record · TAP-RDN-0033TAP 导读: Conceptualizing a resilience research framework at The National Institutes of HealthTAP Record · TAP-RDN-0014TAP 导读: Towards a consensus definition of allostatic load: a multi-cohort, multi-system, multi-biomarker individual participant data (IPD) meta-analysisTAP Record · TAP-RDN-0031TAP 导读: Impact of baseline and longitudinal allostatic load changes on incident cardiovascular disease and all-cause mortality: A 7-year population-based cohort study in ChinaTAP Record · TAP-RDN-0034TAP 导读: Resilience phenotypes derived from an active inference account of allostasisTAP Record · TAP-RDN-0030TAP 导读: Building an ontology of resilience: Insights from the physical resilience literatureTAP Record · TAP-FIG-0001人体适应图谱TAP Record · TAP-FIG-0002恢复轨迹TAP Record · TAP-STD-0001引用与转载