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TAP 导读: Longitudinal analysis of blood markers reveals progressive loss of resilience and predicts human lifespan limit

研究用血细胞指标构建DOSI，并观察其波动自相关随年龄变化。年龄分组的相关时间约为2—8周，支持把动态变化作为候选衰老指标。标题中的120—150岁来自模型向未观察年龄的外推，不是直接测得的人类寿命上限。

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作品信息

TAP ID
TAP-RDN-0052
作品类型
研究导读
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v1.0 · 中文 ↗
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原始出版物

Longitudinal analysis of blood markers reveals progressive loss of resilience and predicts human lifespan limit

Pyrkov TV · Avchaciov K · Tarkhov AE · Menshikov LI · Gudkov AV · Fedichev PO
Nature Communications · 2021

DOI: 10.1038/s41467-021-23014-1 ↗

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项目信息隐私政策项目信息联系我们评估工具TAP 负荷与恢复评估方法负荷与恢复评估：方法与开发探索频道关于人体适应的科学问题探索频道测量与解释阅读指南 · 精选 35 篇负荷与恢复：六条研究线索阅读指南 · 精选 5 篇适应负荷阅读指南 · 精选 5 篇恢复科学阅读指南 · 精选 5 篇储备与复原力阅读指南 · 精选 5 篇测量与解释基础概念负荷Load基础概念动态适应Allostasis基础概念恢复Recovery基础概念适应负荷Allostatic Load基础概念生理储备Physiological Reserve基础概念复原力Resilience科学专题适应负荷：适应的隐性成本科学专题恢复，不只是休息科学专题什么是复原力营养？科学专题适应模型：不同框架分别解释什么？科学专题TAP 人体动态适应框架科学专题HRV 下降了：正常波动，还是恢复状态发生了变化？科学专题HRV 能告诉我们多少关于恢复的信息？科学专题为什么下班了，身体还没有“下班”？科学专题吃得不够，会影响恢复吗？科学专题周末补觉，能补回一周的睡眠不足吗？科学专题怎样证明一种营养干预支持恢复？科学专题恢复一定意味着回到原来的基线吗？科学专题恢复与复原力是一回事吗？科学专题感觉好一些，为什么不一定代表已经恢复？科学专题手表上的恢复分数，到底在告诉你什么？科学专题生理储备与复原力是什么关系？方法与项目证据分级与评价方法方法与项目编辑与科学标准方法与项目关于项目研究文献 · 1993Stress and the individual. Mechanisms leading to disease研究文献 · 1998Protective and damaging effects of stress mediators研究文献 · 2001Frailty in older adults: evidence for a phenotype研究文献 · 2003The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation研究文献 · 2004Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research研究文献 · 2006The perseverative cognition hypothesis: a review of worry, prolonged stress-related physiological activation, and health研究文献 · 2007The Recovery Experience Questionnaire: development and validation of a measure for assessing recuperation and unwinding from work研究文献 · 2009The Reactive Scope Model — A new model integrating homeostasis, allostasis, and stress研究文献 · 2010Neurobehavioral dynamics following chronic sleep restriction: dose-response effects of one night for recovery研究文献 · 2010Greater cardiovascular responses to laboratory mental stress are associated with poor subsequent cardiovascular risk status: a meta-analysis of prospective evidence研究文献 · 2010Allostatic load biomarkers of chronic stress and impact on health and cognition研究文献 · 2011Stress- and Allostasis-Induced Brain Plasticity研究文献 · 2012Job strain as a risk factor for coronary heart disease: a collaborative meta-analysis of individual participant data研究文献 · 2012Allostasis: a model of predictive regulation研究文献 · 2012A meta-analysis of heart rate variability and neuroimaging studies: implications for heart rate variability as a marker of stress and health研究文献 · 2012Protein supplementation improves physical performance in frail elderly people: a randomized, double-blind, placebo-controlled trial研究文献 · 2013Timing and distribution of protein ingestion during prolonged recovery from resistance exercise alters myofibrillar protein synthesis研究文献 · 2013The LF/HF ratio does not accurately measure cardiac sympatho-vagal balance研究文献 · 2013Effects of recovery sleep after one work week of mild sleep restriction on interleukin-6 and cortisol secretion and daytime sleepiness and performance研究文献 · 2013Sleep drives metabolite clearance from the adult brain研究文献 · 2014Monitoring training status with HR measures: do all roads lead to Rome?研究文献 · 2014Clarifying the roles of homeostasis and allostasis in physiological regulation研究文献 · 2014Resilience definitions, theory, and challenges: interdisciplinary perspectives研究文献 · 2015Recovery from job stress: The stressor-detachment model as an integrative framework研究文献 · 2016Physiological concomitants of perseverative cognition: A systematic review and meta-analysis研究文献 · 2016Successfully leaving work at work: The self-regulatory underpinnings of psychological detachment研究文献 · 2016Physical Resilience in Older Adults: Systematic Review and Development of an Emerging Construct研究文献 · 2017Diurnal cortisol slopes and mental and physical health outcomes: A systematic review and meta-analysis研究文献 · 2017Evidence for a Large-Scale Brain System Supporting Allostasis and Interoception in Humans研究文献 · 2017Heart Rate Variability and Cardiac Vagal Tone in Psychophysiological Research - Recommendations for Experiment Planning, Data Analysis, and Data Reporting研究文献 · 2017The impact of reduced worktime on sleep and perceived stress - a group randomized intervention study using diary data研究文献 · 2017A Meta-Analysis on Antecedents and Outcomes of Detachment from Work研究文献 · 2017Multi-parameter comparison of a standardized mixed meal tolerance test in healthy and type 2 diabetic subjects: the PhenFlex challenge研究文献 · 2018Recovery and Performance in Sport: Consensus Statement研究文献 · 2018Quantifying resilience of humans and other animals研究文献 · 2019Ad libitum Weekend Recovery Sleep Fails to Prevent Metabolic Dysregulation during a Repeating Pattern of Insufficient Sleep and Weekend Recovery Sleep研究文献 · 2019Resilience in Clinical Care: Getting a Grip on the Recovery Potential of Older Adults研究文献 · 2019Protein supplementation improves lean body mass in physically active older adults: a randomized placebo-controlled trial研究文献 · 2020Effect of Multimodal Prehabilitation vs Postoperative Rehabilitation on 30-Day Postoperative Complications for Frail Patients Undergoing Resection of Colorectal Cancer: A Randomized Clinical Trial研究文献 · 2020Whitepaper: Defining and investigating cognitive reserve, brain reserve, and brain maintenance研究文献 · 2021Longitudinal analysis of blood markers reveals progressive loss of resilience and predicts human lifespan limit研究文献 · 2021Leaving Work at Work: A Meta-Analysis on Employee Recovery From Work研究文献 · 2022"Give me a break!" A systematic review and meta-analysis on the efficacy of micro-breaks for increasing well-being and performance研究文献 · 2022Allostatic Load Measurement: A Systematic Review of Reviews, Database Inventory, and Considerations for Neighborhood Research研究文献 · 2022Allostatic Load and Mortality: A Systematic Review and Meta-Analysis研究文献 · 2022Recovery from Work: Advancing the Field Toward the Future研究文献 · 2023Brief structured respiration practices enhance mood and reduce physiological arousal研究文献 · 2023Conceptualizing a resilience research framework at The National Institutes of Health研究文献 · 2023Towards a consensus definition of allostatic load: a multi-cohort, multi-system, multi-biomarker individual participant data (IPD) meta-analysis研究文献 · 2023Effect of Multimodal Prehabilitation on Reducing Postoperative Complications and Enhancing Functional Capacity Following Colorectal Cancer Surgery: The PREHAB Randomized Clinical Trial研究文献 · 20232023 International Olympic Committee’s (IOC) consensus statement on Relative Energy Deficiency in Sport (REDs)研究文献 · 2023Low energy availability reduces myofibrillar and sarcoplasmic muscle protein synthesis in trained females研究文献 · 2024Low energy availability increases immune cell formation of reactive oxygen species and impairs exercise performance in female endurance athletes研究文献 · 2024Impact of baseline and longitudinal allostatic load changes on incident cardiovascular disease and all-cause mortality: A 7-year population-based cohort study in China研究文献 · 2024Brain clearance is reduced during sleep and anesthesia研究文献 · 2024Sleep regularity is a stronger predictor of mortality risk than sleep duration: A prospective cohort study研究文献 · 2025Allostatic (over)Load Measurement: Workflow and repository研究文献 · 2025Validation of nocturnal resting heart rate and heart rate variability in consumer wearables研究文献 · 2025Readiness, recovery, and strain: an evaluation of composite health scores in consumer wearables研究文献 · 2025Resilience phenotypes derived from an active inference account of allostasis研究文献 · 2025A meta-analysis of the influence of work connectivity behavior after-hours on employees: The mediating role of work autonomy and psychological detachment研究文献 · 2025Inter- and Intrapersonal Associations Between Physiology and Mental Health: A Longitudinal Study Using Wearables and Mental Health Surveys研究文献 · 2026Allostatic (over) load measurement: Workflow and repository研究文献 · 2026A reporting checklist for human and animal heart rate variability research研究文献 · 2026Acute sleep rebound following sleep restriction is associated with reduced mortality risk研究文献 · 2026Building an ontology of resilience: Insights from the physical resilience literature研究文献 · 2026Pilot study of the impact of weekend sleep restriction and recovery sleep on metabolic and cardiovascular risk indicators: Results from a randomized crossover clinical trialTAP Record · TAP-CON-0001负荷TAP Record · TAP-CON-0002动态适应TAP Record · TAP-CON-0003恢复TAP Record · TAP-CON-0004适应负荷TAP Record · TAP-CON-0005生理储备TAP Record · TAP-CON-0006复原力TAP Record · TAP-FTR-0001适应负荷：适应的隐性成本TAP Record · TAP-FTR-0002恢复，不只是休息TAP Record · TAP-FTR-0009什么是复原力营养？TAP Record · TAP-FTR-0008适应模型：不同框架分别解释什么？TAP Record · TAP-MDL-0001TAP 人体动态适应框架TAP Record · TAP-FTR-0014HRV 下降了：正常波动，还是恢复状态发生了变化？TAP Record · TAP-FTR-0005HRV 能告诉我们多少关于恢复的信息？TAP Record · TAP-FTR-0010为什么下班了，身体还没有“下班”？TAP Record · TAP-FTR-0015吃得不够，会影响恢复吗？TAP Record · TAP-FTR-0013周末补觉，能补回一周的睡眠不足吗？TAP Record · TAP-FTR-0012怎样证明一种营养干预支持恢复？TAP Record · TAP-FTR-0007恢复一定意味着回到原来的基线吗？TAP Record · TAP-FTR-0006恢复与复原力是一回事吗？TAP Record · TAP-FTR-0003感觉好一些，为什么不一定代表已经恢复？TAP Record · TAP-FTR-0011手表上的恢复分数，到底在告诉你什么？TAP Record · TAP-FTR-0004生理储备与复原力是什么关系？TAP Record · TAP-RDN-0001TAP 导读: Stress and the individual. Mechanisms leading to diseaseTAP Record · TAP-RDN-0002TAP 导读: Protective and damaging effects of stress mediatorsTAP Record · TAP-RDN-0067TAP 导读: Frailty in older adults: evidence for a phenotypeTAP Record · TAP-RDN-0003TAP 导读: The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivationTAP Record · TAP-RDN-0050TAP 导读: Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory researchTAP Record · TAP-RDN-0016TAP 导读: The perseverative cognition hypothesis: a review of worry, prolonged stress-related physiological activation, and healthTAP Record · TAP-RDN-0020TAP 导读: The Recovery Experience Questionnaire: development and validation of a measure for assessing recuperation and unwinding from workTAP Record · TAP-RDN-0032TAP 导读: The Reactive Scope Model — A new model integrating homeostasis, allostasis, and stressTAP Record · TAP-RDN-0024TAP 导读: Neurobehavioral dynamics following chronic sleep restriction: dose-response effects of one night for recoveryTAP Record · TAP-RDN-0004TAP 导读: Greater cardiovascular responses to laboratory mental stress are associated with poor subsequent cardiovascular risk status: a meta-analysis of prospective evidenceTAP Record · TAP-RDN-0013TAP 导读: Allostatic load biomarkers of chronic stress and impact on health and cognitionTAP Record · TAP-RDN-0005TAP 导读: Stress- and Allostasis-Induced Brain PlasticityTAP Record · TAP-RDN-0060TAP 导读: Job strain as a risk factor for coronary heart disease: a collaborative meta-analysis of individual participant dataTAP Record · TAP-RDN-0006TAP 导读: Allostasis: a model of predictive regulationTAP Record · TAP-RDN-0053TAP 导读: A meta-analysis of heart rate variability and neuroimaging studies: implications for heart rate variability as a marker of stress and healthTAP Record · TAP-RDN-0038TAP 导读: Protein supplementation improves physical performance in frail elderly people: a randomized, double-blind, placebo-controlled trialTAP Record · TAP-RDN-0037TAP 导读: Timing and distribution of protein ingestion during prolonged recovery from resistance exercise alters myofibrillar protein synthesisTAP Record · TAP-RDN-0018TAP 导读: The LF/HF ratio does not accurately measure cardiac sympatho-vagal balanceTAP Record · TAP-RDN-0026TAP 导读: Effects of recovery sleep after one work week of mild sleep restriction on interleukin-6 and cortisol secretion and daytime sleepiness and performanceTAP Record · TAP-RDN-0062TAP 导读: Sleep drives metabolite clearance from the adult brainTAP Record · TAP-RDN-0044TAP 导读: Monitoring training status with HR measures: do all roads lead to Rome?TAP Record · TAP-RDN-0012TAP 导读: Clarifying the roles of homeostasis and allostasis in physiological regulationTAP Record · TAP-RDN-0029TAP 导读: Resilience definitions, theory, and challenges: interdisciplinary perspectivesTAP Record · TAP-RDN-0007TAP 导读: Recovery from job stress: The stressor-detachment model as an integrative frameworkTAP Record · TAP-RDN-0017TAP 导读: Physiological concomitants of perseverative cognition: A systematic review and meta-analysisTAP Record · TAP-RDN-0040TAP 导读: Successfully leaving work at work: The self-regulatory underpinnings of psychological detachmentTAP Record · TAP-RDN-0008TAP 导读: Physical Resilience in Older Adults: Systematic Review and Development of an Emerging ConstructTAP Record · TAP-RDN-0051TAP 导读: Diurnal cortisol slopes and mental and physical health outcomes: A systematic review and meta-analysisTAP Record · TAP-RDN-0049TAP 导读: Evidence for a Large-Scale Brain System Supporting Allostasis and Interoception in HumansTAP Record · TAP-RDN-0019TAP 导读: Heart Rate Variability and Cardiac Vagal Tone in Psychophysiological Research - 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